Matches in SemOpenAlex for { <https://semopenalex.org/work/W1799359969> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W1799359969 endingPage "4360" @default.
- W1799359969 startingPage "4351" @default.
- W1799359969 abstract "Abstract The effects of IL-4 and IL-5 on the production of Ig of different isotypes was investigated. We compared B cells from spleen and from Peyer's patches either stimulated with LPS or without added polyclonal stimulation. We also compared high density (small) and low density (large) B cells. The effect of lymphokines depended on the size and source of the B cells as well as on whether LPS was added. As expected, small B cells from either lymphoid compartment responded to LPS alone and IL-4 suppressed IgM and IgG3 production and enhanced IgG1. In contrast, when large B cells were examined, the suppressive effects of IL-4 were much less apparent but the enhancement of IgG1 was still marked. IL-5 alone had only minimal effects in LPS-stimulated cultures but the combination of IL-4 plus IL-5 appeared to overcome much of the IL-4-mediated suppression of IgM, and IgA production was enhanced. In the absence of LPS, a quite different profile is seen. First, small B cells make little if any response. Second, there is dramatic synergy between IL-4 and IL-5 in the response of large B cells, which is independent of isotype. Third, IL-4 does not suppress any isotype in the absence of LPS. Fourth, IL-4 plus IL-5 stimulate large Peyer's patch B cells to produce 10 times more IgA but three times less IgM than large spleen B cells. Fifth, Th2 cells directly stimulate both large and small B cells." @default.
- W1799359969 created "2016-06-24" @default.
- W1799359969 creator A5053453474 @default.
- W1799359969 creator A5071010117 @default.
- W1799359969 creator A5087475876 @default.
- W1799359969 date "1989-06-15" @default.
- W1799359969 modified "2023-10-04" @default.
- W1799359969 title "Regulation of isotype production by IL-4 and IL-5. Effects of lymphokines on Ig production depend on the state of activation of the responding B cells." @default.
- W1799359969 doi "https://doi.org/10.4049/jimmunol.142.12.4351" @default.
- W1799359969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2786030" @default.
- W1799359969 hasPublicationYear "1989" @default.
- W1799359969 type Work @default.
- W1799359969 sameAs 1799359969 @default.
- W1799359969 citedByCount "30" @default.
- W1799359969 crossrefType "journal-article" @default.
- W1799359969 hasAuthorship W1799359969A5053453474 @default.
- W1799359969 hasAuthorship W1799359969A5071010117 @default.
- W1799359969 hasAuthorship W1799359969A5087475876 @default.
- W1799359969 hasBestOaLocation W17993599691 @default.
- W1799359969 hasConcept C134018914 @default.
- W1799359969 hasConcept C137756551 @default.
- W1799359969 hasConcept C153911025 @default.
- W1799359969 hasConcept C159654299 @default.
- W1799359969 hasConcept C191732599 @default.
- W1799359969 hasConcept C203014093 @default.
- W1799359969 hasConcept C24998067 @default.
- W1799359969 hasConcept C2777991845 @default.
- W1799359969 hasConcept C2778453870 @default.
- W1799359969 hasConcept C2780931953 @default.
- W1799359969 hasConcept C49382859 @default.
- W1799359969 hasConcept C542903549 @default.
- W1799359969 hasConcept C86803240 @default.
- W1799359969 hasConcept C8891405 @default.
- W1799359969 hasConcept C956191 @default.
- W1799359969 hasConceptScore W1799359969C134018914 @default.
- W1799359969 hasConceptScore W1799359969C137756551 @default.
- W1799359969 hasConceptScore W1799359969C153911025 @default.
- W1799359969 hasConceptScore W1799359969C159654299 @default.
- W1799359969 hasConceptScore W1799359969C191732599 @default.
- W1799359969 hasConceptScore W1799359969C203014093 @default.
- W1799359969 hasConceptScore W1799359969C24998067 @default.
- W1799359969 hasConceptScore W1799359969C2777991845 @default.
- W1799359969 hasConceptScore W1799359969C2778453870 @default.
- W1799359969 hasConceptScore W1799359969C2780931953 @default.
- W1799359969 hasConceptScore W1799359969C49382859 @default.
- W1799359969 hasConceptScore W1799359969C542903549 @default.
- W1799359969 hasConceptScore W1799359969C86803240 @default.
- W1799359969 hasConceptScore W1799359969C8891405 @default.
- W1799359969 hasConceptScore W1799359969C956191 @default.
- W1799359969 hasIssue "12" @default.
- W1799359969 hasLocation W17993599691 @default.
- W1799359969 hasLocation W17993599692 @default.
- W1799359969 hasOpenAccess W1799359969 @default.
- W1799359969 hasPrimaryLocation W17993599691 @default.
- W1799359969 hasRelatedWork W1799359969 @default.
- W1799359969 hasRelatedWork W1982437668 @default.
- W1799359969 hasRelatedWork W1999187269 @default.
- W1799359969 hasRelatedWork W2041647537 @default.
- W1799359969 hasRelatedWork W2043945613 @default.
- W1799359969 hasRelatedWork W2119037101 @default.
- W1799359969 hasRelatedWork W2177385981 @default.
- W1799359969 hasRelatedWork W2402998370 @default.
- W1799359969 hasRelatedWork W2617533691 @default.
- W1799359969 hasRelatedWork W4313354683 @default.
- W1799359969 hasVolume "142" @default.
- W1799359969 isParatext "false" @default.
- W1799359969 isRetracted "false" @default.
- W1799359969 magId "1799359969" @default.
- W1799359969 workType "article" @default.