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- W1799360651 abstract "The cytoplasmic linker protein (CLIP)-170 localizes to kinetochores and is suggested to function in stable attachment of kinetochores to microtubule ends. Here we show that defects in kinetochore-microtubule attachment and chromosome alignment in CLIP-170-depleted cells were rescued by co-depletion of p150glued, a dynactin subunit required for kinetochore localization of CLIP-170. CLIP-170 recruited p150glued to microtubule ends. Kinetochore localization at microtubule ends was perturbed by CLIP-170 depletion, which was rescued by co-depleting p150glued. Our results imply that CLIP-170 tethers kinetochores to microtubule ends against the dynein-mediated poleward force to slide kinetochores along microtubules, facilitating the stable kinetochore attachment to microtubules." @default.
- W1799360651 created "2016-06-24" @default.
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- W1799360651 date "2015-07-29" @default.
- W1799360651 modified "2023-10-12" @default.
- W1799360651 title "CLIP‐170 tethers kinetochores to microtubule plus ends against poleward force by dynein for stable kinetochore–microtubule attachment" @default.
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- W1799360651 doi "https://doi.org/10.1016/j.febslet.2015.07.036" @default.
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