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- W179937460 abstract "In 1989, the U.S. Congress passed a resolution designating the 1990s as the Decade of the Brain.(1) In citing its justification for this resolution, Congress noted that 50 million Americans are affected each year by disorders and disabilities involving the brain. Brain related diseases and injuries cost the United States more than $500 billion annually in health care, lost productivity, and care giving and account for the majority of the U.S. costs for long-term care.(2) The financial burden aside, the intangible human costs of brain-related disorders are inestimable and often devastate the families and friends of those affected by such neurodegenerating afflictions as Alzheimer's disease and brain and spinal cord injury. Aging of the population alone promises to drastically increase the incidence of these and other neural diseases. The decade of the brain is timely in the context of rapid research advances in the identification of complex anatomical connections; increased understanding of the biochemical, molecular, and genetic mechanisms that control brain structure and functions; the ability to measure and visualize human brain functioning during mental activity; and the capacity for monitoring many activities simultaneously in complicated neural networks. The age of psychotechnology has arrived, and it is accompanied by a growing arsenal of techniques for controlling the physical, chemical, and perhaps even the genetic aspects of the brain. In addition to treating neural diseases and disorders, these innovations promise increasingly precise and effective methods for predicting, modifying, and controlling individual behavior. Although some molecular biologists might disagree, Dennis J. Selkoe, co-director of the Center for Neurologic Diseases at Brigham and Women's Hospital in Boston and professor of neurology at Harvard University, concludes: Neuroscience is probably the great frontier now in biomedical science. It might have been cancer and cardiovascular disease a few years ago and before that infectious diseases. Almost everything that you read about science now that is really the most exciting development relates to figuring out how the brain works.(3) Pondering the Brain Historically, any intervention into the brain has engendered political debate. Although crude frontal lobotomies have given way to more precise surgical procedures, use of psychosurgery to treat behavioral disorders or mental illnesses that lack clear organic causes remains controversial. Likewise, while the American Psychiatric Association has approved electroconvulsive therapy as safe and effective for certain severe mental illnesses, political opposition and state legislation have severely restricted its use, to the detriment of some patients.(4) Moreover, current controversy over the uses and abuses of psychotropic drugs, including the antidepressant Prozac and the stimulant Ritalin used to treat attention deficit disorder, is likely to intensify as the arsenal and variety of chemical intervention expands.(5) This controversy marks only the beginning. Indeed, the public policy issues that have traditionally accompanied intervention in the brain are certain to be amplified and complicated with the advent of innovative procedures, devices, and drugs. Rapid developments in drug interventions for the brain continue. At the 1996 meeting of the Society for Neuroscience, one report suggested that the drug ampakine CX-156 restored memory in elderly men to the level of men in their 20s. The report announced that the drug would soon be tested on Alzheimer's patients. Another report cited a recent study that found that estrogen may relieve symptoms of Alzheimer's disease in postmenopausal women, thus extending potential hormonal treatment directly into the brain.(6) In addition to developing a new generation of pharmaceuticals, scientists are testing more-direct delivery methods. …" @default.
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- W179937460 date "1998-09-22" @default.
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- W179937460 title "Brain Scan: Studying the Human Brain Reveals Complex Issues" @default.
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