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- W1799454977 abstract "Abstract A key issue for the study of tuberculosis infection (TB) is to understand why individuals infected with Mycobacterium tuberculosis experience different clinical outcomes. Elaborating the immune mechanisms that determine whether an infected individual will suffer active TB or latent infection can aid in developing treatment and prevention strategies. To better understand the dynamics of M. tuberculosis infection and immunity, we have developed a virtual human model that qualitatively and quantitatively characterizes the cellular and cytokine control network operational during TB infection. Using this model, we identify key regulatory elements in the host response. In particular, factors affecting cell functions, such as macrophage activation and bactericidal capabilities, and effector T cell functions such as cytotoxicity and cytokine production can each be determinative. The model indicates, however, that even if latency is achieved, it may come at the expense of tissue damage if the response is not properly regulated. A balance in Th1 and Th2 immune responses governed by IFN-γ, IL-10, and IL-4 facilitate this down-regulation. These results are further explored through virtual deletion and depletion experiments." @default.
- W1799454977 created "2016-06-24" @default.
- W1799454977 creator A5054065596 @default.
- W1799454977 creator A5067786863 @default.
- W1799454977 date "2001-02-01" @default.
- W1799454977 modified "2023-10-07" @default.
- W1799454977 title "A Model to Predict Cell-Mediated Immune Regulatory Mechanisms During Human Infection with<i>Mycobacterium tuberculosis</i>" @default.
- W1799454977 cites W1487331723 @default.
- W1799454977 cites W1506273507 @default.
- W1799454977 cites W1510730676 @default.
- W1799454977 cites W1514549604 @default.
- W1799454977 cites W1515615230 @default.
- W1799454977 cites W1521353535 @default.
- W1799454977 cites W1532427044 @default.
- W1799454977 cites W1535307867 @default.
- W1799454977 cites W1541692135 @default.
- W1799454977 cites W1549438168 @default.
- W1799454977 cites W1549471387 @default.
- W1799454977 cites W1555399299 @default.
- W1799454977 cites W1580932873 @default.
- W1799454977 cites W1585570459 @default.
- W1799454977 cites W1591708612 @default.
- W1799454977 cites W1600950965 @default.
- W1799454977 cites W1637215451 @default.
- W1799454977 cites W1637891666 @default.
- W1799454977 cites W1755667520 @default.
- W1799454977 cites W1818840099 @default.
- W1799454977 cites W1819607739 @default.
- W1799454977 cites W1853090825 @default.
- W1799454977 cites W1897226866 @default.
- W1799454977 cites W1902026070 @default.
- W1799454977 cites W191142670 @default.
- W1799454977 cites W1915893748 @default.
- W1799454977 cites W1930226270 @default.
- W1799454977 cites W1942794504 @default.
- W1799454977 cites W1945178855 @default.
- W1799454977 cites W1961123486 @default.
- W1799454977 cites W1970762550 @default.
- W1799454977 cites W1987159402 @default.
- W1799454977 cites W1993600630 @default.
- W1799454977 cites W1995225418 @default.
- W1799454977 cites W1996291400 @default.
- W1799454977 cites W2000128882 @default.
- W1799454977 cites W2000983290 @default.
- W1799454977 cites W2003634025 @default.
- W1799454977 cites W2008209529 @default.
- W1799454977 cites W2010417323 @default.
- W1799454977 cites W2011703114 @default.
- W1799454977 cites W2016422621 @default.
- W1799454977 cites W2019967232 @default.
- W1799454977 cites W2019972235 @default.
- W1799454977 cites W2027272296 @default.
- W1799454977 cites W2029898329 @default.
- W1799454977 cites W2040449073 @default.
- W1799454977 cites W2048597976 @default.
- W1799454977 cites W2059015859 @default.
- W1799454977 cites W2061021775 @default.
- W1799454977 cites W2061521294 @default.
- W1799454977 cites W2062160650 @default.
- W1799454977 cites W2062811432 @default.
- W1799454977 cites W2065791817 @default.
- W1799454977 cites W2067811641 @default.
- W1799454977 cites W2081175663 @default.
- W1799454977 cites W2081199994 @default.
- W1799454977 cites W2088438813 @default.
- W1799454977 cites W2089321956 @default.
- W1799454977 cites W2091372349 @default.
- W1799454977 cites W2094739664 @default.
- W1799454977 cites W2098700395 @default.
- W1799454977 cites W2101377929 @default.
- W1799454977 cites W2101771134 @default.
- W1799454977 cites W2104465882 @default.
- W1799454977 cites W2105101886 @default.
- W1799454977 cites W2106462617 @default.
- W1799454977 cites W2107270161 @default.
- W1799454977 cites W2107357004 @default.
- W1799454977 cites W2107860814 @default.
- W1799454977 cites W2109484445 @default.
- W1799454977 cites W2110042355 @default.
- W1799454977 cites W2115954882 @default.
- W1799454977 cites W2117885943 @default.
- W1799454977 cites W2120384479 @default.
- W1799454977 cites W2120829678 @default.
- W1799454977 cites W2122322602 @default.
- W1799454977 cites W2126321883 @default.
- W1799454977 cites W2129525334 @default.
- W1799454977 cites W2130046741 @default.
- W1799454977 cites W2131502319 @default.
- W1799454977 cites W2131686775 @default.
- W1799454977 cites W2135254713 @default.
- W1799454977 cites W2138785457 @default.
- W1799454977 cites W2140627356 @default.
- W1799454977 cites W2140716261 @default.
- W1799454977 cites W2141507915 @default.
- W1799454977 cites W2141672711 @default.
- W1799454977 cites W2142441544 @default.
- W1799454977 cites W2143029867 @default.
- W1799454977 cites W2143590308 @default.