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• W1799557568 abstract "Publisher Summary This chapter describes some experiments conducted to study in vivo bioassays of central vasopressin V 1 using fever as a model. The efforts have been directed toward elucidating the role of vasopressin in the control of fever and antipyresis within the ventral septal area (VSA) of the rat brain. The VSA is a neuroanatomical locus that contains arginine vasopressin (AVP)-containing axons, terminals, and AVP receptors resembling the peripheral V 1 subtype. The most convincing evidence for a central function for vasopressin arises from cardiovascular, learning and memory, and thermoregulatory investigations. As supported by autoradiographical, homogenate binding, and physiological studies, the central vasopressin receptor resembles the peripheral V 1 subtype. Direct measurements of basal and stimulated AVP release within the VSA neuropil provide convincing corollary evidence for an AVP V 1 -mediated antipyretic mechanism within this central nervous system locus. A model whereby AVP or AVP antagonists are administered centrally to assess the role of endogenous AVP and to characterize the receptor type involved in the regulation of body temperature during fever has been developed." @default.
• W1799557568 created "2016-06-24" @default.
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• W1799557568 date "1991-01-01" @default.
• W1799557568 modified "2023-09-27" @default.
• W1799557568 title "In Vivo Bioassays of Central Vasopressin V1 Receptors Using Fever as a Model" @default.
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• W1799557568 doi "https://doi.org/10.1016/b978-0-12-185259-7.50024-7" @default.
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