FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W17996210> ?p ?o ?g. }

• W17996210 endingPage "237" @default.
• W17996210 startingPage "223" @default.
• W17996210 abstract "Cyanide (CN) intoxication inhibits cellular oxidative metabolism and may result in brain damage. Hydroxycobalamin (OHCob) is one among other antidotes that may be used following intoxication with CN. Hyperbaric oxygen (HBO2) is recommended when supportive measures or antidotes fail. However, the effect of hydroxycobalamin or HBO2 on brain lactate and glucose concentrations during CN intoxication is unknown. We used intracerebral microdialysis to study the in vivo effect of hydroxycobalamin or HBO2 treatment on acute CN-induced deterioration in brain metabolism. Anesthetized rats were allocated to four groups receiving potassium CN (KCN) 5.4 mg/kg or vehicle intra-arterially: 1) vehicle-treated control rats; 2) KCN-poisoned rats; 3) KCN-poisoned rats receiving hydroxycobalamin (25 mg); and 4) KCN-poisoned rats treated with HBO2 (284 kPa for 90 minutes). KCN alone caused a prompt increase in interstitial brain lactate and glucose concentrations peaking at 60 minutes. Both hydroxycobalamin and HBO2 abolished KCN-induced increases in brain lactate and glucose concentration. However, whereas HBO2 treatment increased cerebral PtO2 and reduced respiratory distress and cyanosis, OHCob did not have this beneficial effect. In conclusion, CN intoxication in anesthetized rats produces specific uncoupling of cerebral oxidative metabolism resulting in interstitial lactate and glucose surges that may be ameliorated by treatment with either hydroxycobalamin or HBO2." @default.
• W17996210 created "2016-06-24" @default.
• W17996210 creator A5021762389 @default.
• W17996210 creator A5032179507 @default.
• W17996210 creator A5085948929 @default.
• W17996210 date "2011-01-11" @default.
• W17996210 modified "2023-09-23" @default.
• W17996210 title "Hyperbaric oxygen therapy or hydroxycobalamin attenuates surges in brain interstitial lactate and glucose; and hyperbaric oxygen improves respiratory status in cyanide-intoxicated rats." @default.
• W17996210 cites W141670785 @default.
• W17996210 cites W1702166251 @default.
• W17996210 cites W1907296652 @default.
• W17996210 cites W1968601078 @default.
• W17996210 cites W1974608877 @default.
• W17996210 cites W1974657483 @default.
• W17996210 cites W1976709366 @default.
• W17996210 cites W1976833922 @default.
• W17996210 cites W1983100914 @default.
• W17996210 cites W1988987892 @default.
• W17996210 cites W1990371647 @default.
• W17996210 cites W1991012474 @default.
• W17996210 cites W1997269362 @default.
• W17996210 cites W2005681064 @default.
• W17996210 cites W2007124673 @default.
• W17996210 cites W2009585541 @default.
• W17996210 cites W2014262341 @default.
• W17996210 cites W2017801064 @default.
• W17996210 cites W2019795838 @default.
• W17996210 cites W2026779231 @default.
• W17996210 cites W2033817724 @default.
• W17996210 cites W2033935729 @default.
• W17996210 cites W2034004233 @default.
• W17996210 cites W2036189255 @default.
• W17996210 cites W2041306249 @default.
• W17996210 cites W2042461528 @default.
• W17996210 cites W2044430848 @default.
• W17996210 cites W2049322298 @default.
• W17996210 cites W2051228147 @default.
• W17996210 cites W2054897143 @default.
• W17996210 cites W2058662415 @default.
• W17996210 cites W2065359257 @default.
• W17996210 cites W2066369900 @default.
• W17996210 cites W2069505535 @default.
• W17996210 cites W2071674894 @default.
• W17996210 cites W2076506938 @default.
• W17996210 cites W2080256605 @default.
• W17996210 cites W2086066542 @default.
• W17996210 cites W2101402053 @default.
• W17996210 cites W2101445700 @default.
• W17996210 cites W2101488331 @default.
• W17996210 cites W2110577474 @default.
• W17996210 cites W2115100688 @default.
• W17996210 cites W2117248365 @default.
• W17996210 cites W2123649574 @default.
• W17996210 cites W2128454891 @default.
• W17996210 cites W2130542771 @default.
• W17996210 cites W2131778839 @default.
• W17996210 cites W2142469177 @default.
• W17996210 cites W2156104358 @default.
• W17996210 cites W2156883447 @default.
• W17996210 cites W2159528915 @default.
• W17996210 cites W2160359775 @default.
• W17996210 cites W2164883207 @default.
• W17996210 cites W2171716368 @default.
• W17996210 cites W2403196200 @default.
• W17996210 cites W2797597138 @default.
• W17996210 cites W37631566 @default.
• W17996210 cites W56145643 @default.
• W17996210 cites W67383394 @default.
• W17996210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21877551" @default.
• W17996210 hasPublicationYear "2011" @default.
• W17996210 type Work @default.
• W17996210 sameAs 17996210 @default.
• W17996210 citedByCount "1" @default.
• W17996210 countsByYear W179962102015 @default.
• W17996210 crossrefType "journal-article" @default.
• W17996210 hasAuthorship W17996210A5021762389 @default.
• W17996210 hasAuthorship W17996210A5032179507 @default.
• W17996210 hasAuthorship W17996210A5085948929 @default.
• W17996210 hasConcept C126322002 @default.
• W17996210 hasConcept C150903083 @default.
• W17996210 hasConcept C17093226 @default.
• W17996210 hasConcept C178790620 @default.
• W17996210 hasConcept C179104552 @default.
• W17996210 hasConcept C185592680 @default.
• W17996210 hasConcept C207001950 @default.
• W17996210 hasConcept C2776424019 @default.
• W17996210 hasConcept C2778455166 @default.
• W17996210 hasConcept C2779837674 @default.
• W17996210 hasConcept C28406088 @default.
• W17996210 hasConcept C2994405533 @default.
• W17996210 hasConcept C42219234 @default.
• W17996210 hasConcept C50156730 @default.
• W17996210 hasConcept C534529494 @default.
• W17996210 hasConcept C537181965 @default.
• W17996210 hasConcept C540031477 @default.
• W17996210 hasConcept C55493867 @default.
• W17996210 hasConcept C57600042 @default.
• W17996210 hasConcept C62231903 @default.

• next