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• W1799643451 abstract "A series of aryl-2H-pyrazole derivatives were synthesized and evaluated for inhibitory activity against xanthine oxidase in vitro as potent xanthine oxidase inhibitors. Among them, 2 aryl-2H-pyrazole derivatives showed significant inhibitory activities against xanthine oxidase. Compound 19 emerged as the most potent xanthine oxidase inhibitor (IC50=9.8 µM) in comparison with allopurinol (IC50=9.5 µM). The docking study revealed that compound 19 might have strong interactions with the active site of xanthine oxidase. This compound is thus a new candidate for further development for the treatment of gout." @default.
• W1799643451 created "2016-06-24" @default.
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• W1799643451 date "2015-01-01" @default.
• W1799643451 modified "2023-10-06" @default.
• W1799643451 title "Synthesis and Biological Evaluation of Novel Aryl-2<i>H</i>-pyrazole Derivatives as Potent Non-purine Xanthine Oxidase Inhibitors" @default.
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• W1799643451 doi "https://doi.org/10.1248/cpb.c15-00282" @default.
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