FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1799643604> ?p ?o ?g. }

• W1799643604 endingPage "568" @default.
• W1799643604 startingPage "561" @default.
• W1799643604 abstract "A 15-mer cationic α-helical antimicrobial peptide HPRP-A1 was used as the parent peptide to study the effects of peptide secondary structure on the biophysical properties and biological activities. Without changing the amino acid composition of HPRP-A1, we designed two α-helical peptides with either higher or lower helicity compared with the parent peptide, a β-sheet peptide and a random coiled peptide using de novo design approach. The secondary structures were confirmed by circular dichroism spectroscopy. The three α-helical peptides exhibited comparable antibacterial activities, but their hemolytic activity varied from extreme hemolysis to no hemolysis, which is correlated with their helicity. The β-sheet peptide shows poor antibacterial and strong hemolytic activities. More interestingly, the random coil peptide shows no antibacterial activity against Gram-negative bacteria, weak antibacterial activity against Gram-positive bacteria, and extremely weak hemolytic activity. Bacterial membrane permeabilization was also testified on peptides with different secondary structures. Tryptophan fluorescence experiment revealed that the peptide binding preference to the lipid vesicles for mimicking the prokaryotic or eukaryotic membranes was consistent with their biological activities. With the de novo design approach, we proved that it is important to maintain certain contents of amphipathic secondary structure for a desirable biological activity. We believe that the de novo design approach of relocation of the amino acids within a template sequence could be an effective approach in optimizing the specificity of an antimicrobial peptide." @default.
• W1799643604 created "2016-06-24" @default.
• W1799643604 creator A5026189499 @default.
• W1799643604 creator A5036894207 @default.
• W1799643604 creator A5041845736 @default.
• W1799643604 creator A5052994285 @default.
• W1799643604 creator A5061140388 @default.
• W1799643604 date "2015-03-30" @default.
• W1799643604 modified "2023-10-14" @default.
• W1799643604 title "Effects and mechanisms of the secondary structure on the antimicrobial activity and specificity of antimicrobial peptides" @default.
• W1799643604 cites W1513897103 @default.
• W1799643604 cites W1963817764 @default.
• W1799643604 cites W1973580574 @default.
• W1799643604 cites W1976301815 @default.
• W1799643604 cites W1981366496 @default.
• W1799643604 cites W1983521156 @default.
• W1799643604 cites W1989038765 @default.
• W1799643604 cites W2011615074 @default.
• W1799643604 cites W2021122013 @default.
• W1799643604 cites W2038679282 @default.
• W1799643604 cites W2046704370 @default.
• W1799643604 cites W2051158595 @default.
• W1799643604 cites W2056922005 @default.
• W1799643604 cites W2067234157 @default.
• W1799643604 cites W2068434462 @default.
• W1799643604 cites W2083183071 @default.
• W1799643604 cites W2087125825 @default.
• W1799643604 cites W2092259583 @default.
• W1799643604 cites W2102746141 @default.
• W1799643604 cites W2133056039 @default.
• W1799643604 cites W2145344160 @default.
• W1799643604 cites W2154556219 @default.
• W1799643604 cites W2155482026 @default.
• W1799643604 cites W2158482458 @default.
• W1799643604 cites W2159861471 @default.
• W1799643604 cites W2160780417 @default.
• W1799643604 cites W2163338412 @default.
• W1799643604 cites W2165500804 @default.
• W1799643604 cites W4255507877 @default.
• W1799643604 doi "https://doi.org/10.1002/psc.2767" @default.
• W1799643604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25826179" @default.
• W1799643604 hasPublicationYear "2015" @default.
• W1799643604 type Work @default.
• W1799643604 sameAs 1799643604 @default.
• W1799643604 citedByCount "24" @default.
• W1799643604 countsByYear W17996436042017 @default.
• W1799643604 countsByYear W17996436042018 @default.
• W1799643604 countsByYear W17996436042019 @default.
• W1799643604 countsByYear W17996436042020 @default.
• W1799643604 countsByYear W17996436042021 @default.
• W1799643604 countsByYear W17996436042022 @default.
• W1799643604 countsByYear W17996436042023 @default.
• W1799643604 crossrefType "journal-article" @default.
• W1799643604 hasAuthorship W1799643604A5026189499 @default.
• W1799643604 hasAuthorship W1799643604A5036894207 @default.
• W1799643604 hasAuthorship W1799643604A5041845736 @default.
• W1799643604 hasAuthorship W1799643604A5052994285 @default.
• W1799643604 hasAuthorship W1799643604A5061140388 @default.
• W1799643604 hasConcept C104317684 @default.
• W1799643604 hasConcept C133571119 @default.
• W1799643604 hasConcept C167625842 @default.
• W1799643604 hasConcept C178790620 @default.
• W1799643604 hasConcept C185592680 @default.
• W1799643604 hasConcept C203014093 @default.
• W1799643604 hasConcept C2779281246 @default.
• W1799643604 hasConcept C2779902561 @default.
• W1799643604 hasConcept C2780104969 @default.
• W1799643604 hasConcept C34349673 @default.
• W1799643604 hasConcept C4937899 @default.
• W1799643604 hasConcept C515207424 @default.
• W1799643604 hasConcept C523546767 @default.
• W1799643604 hasConcept C540938839 @default.
• W1799643604 hasConcept C54355233 @default.
• W1799643604 hasConcept C55493867 @default.
• W1799643604 hasConcept C62614982 @default.
• W1799643604 hasConcept C86803240 @default.
• W1799643604 hasConceptScore W1799643604C104317684 @default.
• W1799643604 hasConceptScore W1799643604C133571119 @default.
• W1799643604 hasConceptScore W1799643604C167625842 @default.
• W1799643604 hasConceptScore W1799643604C178790620 @default.
• W1799643604 hasConceptScore W1799643604C185592680 @default.
• W1799643604 hasConceptScore W1799643604C203014093 @default.
• W1799643604 hasConceptScore W1799643604C2779281246 @default.
• W1799643604 hasConceptScore W1799643604C2779902561 @default.
• W1799643604 hasConceptScore W1799643604C2780104969 @default.
• W1799643604 hasConceptScore W1799643604C34349673 @default.
• W1799643604 hasConceptScore W1799643604C4937899 @default.
• W1799643604 hasConceptScore W1799643604C515207424 @default.
• W1799643604 hasConceptScore W1799643604C523546767 @default.
• W1799643604 hasConceptScore W1799643604C540938839 @default.
• W1799643604 hasConceptScore W1799643604C54355233 @default.
• W1799643604 hasConceptScore W1799643604C55493867 @default.
• W1799643604 hasConceptScore W1799643604C62614982 @default.
• W1799643604 hasConceptScore W1799643604C86803240 @default.
• W1799643604 hasFunder F4320310121 @default.
• W1799643604 hasFunder F4320321001 @default.
• W1799643604 hasIssue "7" @default.
• W1799643604 hasLocation W17996436041 @default.

• next