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- W1799783989 abstract "Abstract During the last three years we and other have observed discrepancies between results for creatine kinase isoenzyme MB as measured with the mechanized ion-exchange chromatographic method in the Du Pont aca and those by other techniques. These observations prompted us to investigate the influence of the matrix on the Du Pont CK-MB assay. We conclude that, apart from possible interferences by CK-MM, CK-BB, and both types of macro CK, the aca will give apparent CK-MB activities that are directly related to protein concentration and inversely related to sodium chloride concentration. Practical consequences for the routine and emergency laboratories are: no diluted samples are allowed; application is restricted to samples from patients suspected of acute myocardial infarction which show upper-normal total CK activity; and multiple timed samples are run, in order to recognize the typical change in enzyme pattern with time." @default.
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- W1799783989 date "1984-02-01" @default.
- W1799783989 modified "2023-09-24" @default.
- W1799783989 title "Determination of creatine kinase MB activity with the Du Pont aca: interferences from the sample matrix." @default.
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- W1799783989 doi "https://doi.org/10.1093/clinchem/30.2.238" @default.
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