Matches in SemOpenAlex for { <https://semopenalex.org/work/W1799809595> ?p ?o ?g. }
- W1799809595 endingPage "3513" @default.
- W1799809595 startingPage "3507" @default.
- W1799809595 abstract "In resting cells, c-Jun is phosphorylated on five sites. Three of these sites reside next to its DNA binding domain and negatively regulate DNA binding. In response to expression of oncogenic Ha-Ras, phosphorylation of these sites decreases, while phosphorylation of two other sites within c-Jun's activation domain is greatly enhanced. Phosphorylation of these residues, serines 63 and 73, stimulates the transactivation function of c-Jun and is required for oncogenic cooperation with Ha-Ras. We now show that the same changes in c-Jun phosphorylation are elicited by a variety of transforming oncoproteins with distinct biochemical activities. These oncoproteins, v-Sis, v-Src, Ha-Ras, and Raf-1, participate in a signal transduction pathway that leads to increased phosphorylation of serines 63 and 73 on c-Jun. While oncogenic Ha-Ras is a constitutive stimulator of c-Jun activity and phosphorylation, the normal c-Ha-Ras protein is a serum-dependent modulator of c-Jun's activity. c-Jun is therefore a downstream target for a phosphorylation cascade involved in cell proliferation and transformation." @default.
- W1799809595 created "2016-06-24" @default.
- W1799809595 creator A5001270756 @default.
- W1799809595 creator A5004738391 @default.
- W1799809595 creator A5015247637 @default.
- W1799809595 creator A5041978220 @default.
- W1799809595 creator A5056315342 @default.
- W1799809595 creator A5078875479 @default.
- W1799809595 creator A5082378925 @default.
- W1799809595 date "1992-08-01" @default.
- W1799809595 modified "2023-10-10" @default.
- W1799809595 title "Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73." @default.
- W1799809595 cites W126627744 @default.
- W1799809595 cites W12952247 @default.
- W1799809595 cites W1504158642 @default.
- W1799809595 cites W1811606715 @default.
- W1799809595 cites W1873254229 @default.
- W1799809595 cites W1884488180 @default.
- W1799809595 cites W1906271222 @default.
- W1799809595 cites W1964502048 @default.
- W1799809595 cites W1967004332 @default.
- W1799809595 cites W1977302628 @default.
- W1799809595 cites W1977598234 @default.
- W1799809595 cites W1979118172 @default.
- W1799809595 cites W1983501834 @default.
- W1799809595 cites W1986157687 @default.
- W1799809595 cites W1994975139 @default.
- W1799809595 cites W1995136152 @default.
- W1799809595 cites W2005529016 @default.
- W1799809595 cites W2011147958 @default.
- W1799809595 cites W2012383791 @default.
- W1799809595 cites W2021052287 @default.
- W1799809595 cites W2042260090 @default.
- W1799809595 cites W2045397841 @default.
- W1799809595 cites W2045500858 @default.
- W1799809595 cites W2058744360 @default.
- W1799809595 cites W2082961684 @default.
- W1799809595 cites W2094872845 @default.
- W1799809595 cites W2109583847 @default.
- W1799809595 cites W2126440278 @default.
- W1799809595 cites W2143678301 @default.
- W1799809595 cites W2158608327 @default.
- W1799809595 cites W2403720363 @default.
- W1799809595 cites W2414820236 @default.
- W1799809595 cites W2468882383 @default.
- W1799809595 cites W2498448928 @default.
- W1799809595 cites W2184929176 @default.
- W1799809595 cites W62887377 @default.
- W1799809595 doi "https://doi.org/10.1128/mcb.12.8.3507" @default.
- W1799809595 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/364600" @default.
- W1799809595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1630458" @default.
- W1799809595 hasPublicationYear "1992" @default.
- W1799809595 type Work @default.
- W1799809595 sameAs 1799809595 @default.
- W1799809595 citedByCount "269" @default.
- W1799809595 countsByYear W17998095952012 @default.
- W1799809595 countsByYear W17998095952013 @default.
- W1799809595 countsByYear W17998095952014 @default.
- W1799809595 countsByYear W17998095952015 @default.
- W1799809595 countsByYear W17998095952016 @default.
- W1799809595 countsByYear W17998095952017 @default.
- W1799809595 countsByYear W17998095952018 @default.
- W1799809595 countsByYear W17998095952019 @default.
- W1799809595 countsByYear W17998095952020 @default.
- W1799809595 countsByYear W17998095952021 @default.
- W1799809595 countsByYear W17998095952022 @default.
- W1799809595 crossrefType "journal-article" @default.
- W1799809595 hasAuthorship W1799809595A5001270756 @default.
- W1799809595 hasAuthorship W1799809595A5004738391 @default.
- W1799809595 hasAuthorship W1799809595A5015247637 @default.
- W1799809595 hasAuthorship W1799809595A5041978220 @default.
- W1799809595 hasAuthorship W1799809595A5056315342 @default.
- W1799809595 hasAuthorship W1799809595A5078875479 @default.
- W1799809595 hasAuthorship W1799809595A5082378925 @default.
- W1799809595 hasBestOaLocation W17998095951 @default.
- W1799809595 hasConcept C104317684 @default.
- W1799809595 hasConcept C104551158 @default.
- W1799809595 hasConcept C11960822 @default.
- W1799809595 hasConcept C1292079 @default.
- W1799809595 hasConcept C153911025 @default.
- W1799809595 hasConcept C2776414213 @default.
- W1799809595 hasConcept C2780307904 @default.
- W1799809595 hasConcept C55493867 @default.
- W1799809595 hasConcept C62478195 @default.
- W1799809595 hasConcept C86339819 @default.
- W1799809595 hasConcept C86803240 @default.
- W1799809595 hasConcept C87325107 @default.
- W1799809595 hasConcept C95444343 @default.
- W1799809595 hasConcept C97029542 @default.
- W1799809595 hasConceptScore W1799809595C104317684 @default.
- W1799809595 hasConceptScore W1799809595C104551158 @default.
- W1799809595 hasConceptScore W1799809595C11960822 @default.
- W1799809595 hasConceptScore W1799809595C1292079 @default.
- W1799809595 hasConceptScore W1799809595C153911025 @default.
- W1799809595 hasConceptScore W1799809595C2776414213 @default.
- W1799809595 hasConceptScore W1799809595C2780307904 @default.
- W1799809595 hasConceptScore W1799809595C55493867 @default.
- W1799809595 hasConceptScore W1799809595C62478195 @default.