Matches in SemOpenAlex for { <https://semopenalex.org/work/W179982204> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W179982204 endingPage "7" @default.
- W179982204 startingPage "62" @default.
- W179982204 abstract "In the process of identification of tumor-associated antigens that elicit immunological responses in cancer patients, evidence for the existence of non-traditional immunogens with little sequence homologies to normal open reading frames has been revealed. The generation of non-traditional immunogens is either transcriptionally controlled (by activation of pepton, cryptic promoter activation, splicing events, or chromosomal rearrangements) or translationally controlled (by frameshift mutation or translation from an alternative open reading frame). The non-traditional immunogen may possess either an epitope (antigenic determinant of a true antigen) or mimotope (mimics or structural equivalents of epitopes of a true antigen). In vitro studies have revealed the presence of mimotope-specific CD8+ T-cells in cancer patients, suggesting that these mimotopes could represent a natural alternative to T-cells. In cases in which tumor antigens are overexpressed in cancer, mimotopes can overcome tolerance by activating T-cell receptors (TCRs) that originally had low avidity for their respective tumor antigens. Peptide mimotopes have been shown to possess the MHC binding motif and cause efficient activation of T-cells. Indeed, mimotopes from an epitope of melanoma cell-adhesion molecule can elicit both humoral and cytotoxic T-lymphocyte immune responses in mice. Furthermore, studies suggest that mimotopes could be excellent targets for cancer immunotherapy. This review summarizes the discovery and functional characteristics of non-traditional immunogens, in particular mimotopes in cancer immunotherapy." @default.
- W179982204 created "2016-06-24" @default.
- W179982204 creator A5007987600 @default.
- W179982204 creator A5071436332 @default.
- W179982204 date "2008-02-01" @default.
- W179982204 modified "2023-09-27" @default.
- W179982204 title "Non-traditional immunogens and their application to immunotherapy." @default.
- W179982204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18228183" @default.
- W179982204 hasPublicationYear "2008" @default.
- W179982204 type Work @default.
- W179982204 sameAs 179982204 @default.
- W179982204 citedByCount "1" @default.
- W179982204 crossrefType "journal-article" @default.
- W179982204 hasAuthorship W179982204A5007987600 @default.
- W179982204 hasAuthorship W179982204A5071436332 @default.
- W179982204 hasConcept C147483822 @default.
- W179982204 hasConcept C154317977 @default.
- W179982204 hasConcept C159654299 @default.
- W179982204 hasConcept C195616568 @default.
- W179982204 hasConcept C202751555 @default.
- W179982204 hasConcept C203014093 @default.
- W179982204 hasConcept C207936829 @default.
- W179982204 hasConcept C2777701055 @default.
- W179982204 hasConcept C2779909307 @default.
- W179982204 hasConcept C2780674031 @default.
- W179982204 hasConcept C542903549 @default.
- W179982204 hasConcept C54355233 @default.
- W179982204 hasConcept C86803240 @default.
- W179982204 hasConcept C8891405 @default.
- W179982204 hasConcept C9365378 @default.
- W179982204 hasConceptScore W179982204C147483822 @default.
- W179982204 hasConceptScore W179982204C154317977 @default.
- W179982204 hasConceptScore W179982204C159654299 @default.
- W179982204 hasConceptScore W179982204C195616568 @default.
- W179982204 hasConceptScore W179982204C202751555 @default.
- W179982204 hasConceptScore W179982204C203014093 @default.
- W179982204 hasConceptScore W179982204C207936829 @default.
- W179982204 hasConceptScore W179982204C2777701055 @default.
- W179982204 hasConceptScore W179982204C2779909307 @default.
- W179982204 hasConceptScore W179982204C2780674031 @default.
- W179982204 hasConceptScore W179982204C542903549 @default.
- W179982204 hasConceptScore W179982204C54355233 @default.
- W179982204 hasConceptScore W179982204C86803240 @default.
- W179982204 hasConceptScore W179982204C8891405 @default.
- W179982204 hasConceptScore W179982204C9365378 @default.
- W179982204 hasIssue "1" @default.
- W179982204 hasLocation W1799822041 @default.
- W179982204 hasOpenAccess W179982204 @default.
- W179982204 hasPrimaryLocation W1799822041 @default.
- W179982204 hasRelatedWork W1753684754 @default.
- W179982204 hasRelatedWork W2002645324 @default.
- W179982204 hasRelatedWork W2006653124 @default.
- W179982204 hasRelatedWork W2037240393 @default.
- W179982204 hasRelatedWork W2061357489 @default.
- W179982204 hasRelatedWork W2065133669 @default.
- W179982204 hasRelatedWork W2076534279 @default.
- W179982204 hasRelatedWork W2084037902 @default.
- W179982204 hasRelatedWork W2159120850 @default.
- W179982204 hasRelatedWork W2174492283 @default.
- W179982204 hasRelatedWork W2207837324 @default.
- W179982204 hasRelatedWork W2214098511 @default.
- W179982204 hasRelatedWork W2250450071 @default.
- W179982204 hasRelatedWork W2397573220 @default.
- W179982204 hasRelatedWork W2462471616 @default.
- W179982204 hasRelatedWork W2463294209 @default.
- W179982204 hasRelatedWork W2765160759 @default.
- W179982204 hasRelatedWork W2991639973 @default.
- W179982204 hasRelatedWork W4214902721 @default.
- W179982204 hasRelatedWork W3088488167 @default.
- W179982204 hasVolume "10" @default.
- W179982204 isParatext "false" @default.
- W179982204 isRetracted "false" @default.
- W179982204 magId "179982204" @default.
- W179982204 workType "article" @default.