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- W179988081 abstract "There are no studies of breast milk vitamin B12 in groups with a range of B12 status, and previous methods are invalid due to failure to remove apohaptocorrin (apoHc) prior to analysis. B12 was measured in breast milk collected at 12 ± 0.5 mo postpartum from 129 women in a low income Guatemalan community. Complete data on maternal and infant plasma B12 and intakes were available for 83 mother-infant pairs. Plasma B12 was measured (competitive protein-binding radioassay) and cut-offs designated Deficient (<148 pmol/L), Marginal (148-220 pmol/L) and Adequate (>220 pmol/L) maternal and infant status. Milk B12 was analyzed by chemiluminescence after removing apoHc by cobinamide-coated EAH sepharose gel. One third of women were B12 Deficient, one third had Marginal status, and 88% of infants were Deficient or Marginal. Both infant plasma and breast milk B12 were sig. higher in Adequate vs Deficient or Marginal status women. Breast milk B12 was below the detectable limit of 50 pmol/L in 47% of samples, none from Adequate mothers. In the Adequate group milk B12 averaged 128 pmol/L, vs. 870 pmol/L in 21 healthy Californian women, providing only ≈0.1 ug/d for exclusively breastfed infants. Maternal plasma B12 correlated with milk and infant plasma B12 (both r=0.36, P<0.001), and milk correlated with maternal intake. Since high B12 doses to mothers did not improve infant status, interventions are needed before/during pregnancy." @default.
- W179988081 created "2016-06-24" @default.
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- W179988081 date "2009-04-01" @default.
- W179988081 modified "2023-10-10" @default.
- W179988081 title "Breast milk vitamin B12 concentrations in Guatemala: relationship to maternal and infant intake and status" @default.
- W179988081 doi "https://doi.org/10.1096/fasebj.23.1_supplement.344.3" @default.
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