Matches in SemOpenAlex for { <https://semopenalex.org/work/W1799894364> ?p ?o ?g. }
- W1799894364 endingPage "5937" @default.
- W1799894364 startingPage "5928" @default.
- W1799894364 abstract "α 2 -Adrenergic receptors (α 2 -ARs) mediate a number of physiological phenomena, including spinal analgesia. We have developed subtype-selective antisera against the C termini of the α 2A -AR and α 2C -AR to investigate the relative distribution and cellular source or sources of these receptor subtypes in the rat spinal cord. Immunoreactivity (IR) for both receptor subtypes was observed in the superficial layers of the dorsal horn of the spinal cord. Our results suggest that the primary localization of the α 2A -AR in the rat spinal cord is on the terminals of capsaicin-sensitive, substance P (SP)-containing primary afferent fibers. In contrast, the majority of α 2C -AR-IR was not of primary afferent origin, not strongly colocalized with SP-IR, and not sensitive to neonatal capsaicin treatment. Spinal α 2C -AR-IR does not appear to colocalize with the neurokinin-1 receptor, nor is it localized on astrocytes, as evidenced by a lack of costaining with the glial marker GFAP. However, some colocalization was observed between α 2C -AR-IR and enkephalin-IR, suggesting that the α 2C -AR may be expressed by a subset of spinal interneurons. Interestingly, neither subtype was detected on descending noradrenergic terminals. These results indicate that the α 2 -AR subtypes investigated are likely expressed by different subpopulations of neurons and may therefore subserve different physiological functions in the spinal cord, with the α 2A -AR being more likely to play a role in the modulation of nociceptive information." @default.
- W1799894364 created "2016-06-24" @default.
- W1799894364 creator A5010308197 @default.
- W1799894364 creator A5023725612 @default.
- W1799894364 creator A5029048687 @default.
- W1799894364 creator A5064048333 @default.
- W1799894364 creator A5077494149 @default.
- W1799894364 creator A5084173178 @default.
- W1799894364 creator A5088477446 @default.
- W1799894364 date "1998-08-01" @default.
- W1799894364 modified "2023-10-18" @default.
- W1799894364 title "Differential Distribution of α<sub>2A</sub>and α<sub>2C</sub>Adrenergic Receptor Immunoreactivity in the Rat Spinal Cord" @default.
- W1799894364 cites W1501139717 @default.
- W1799894364 cites W1591789321 @default.
- W1799894364 cites W1592358009 @default.
- W1799894364 cites W1635719627 @default.
- W1799894364 cites W1841227142 @default.
- W1799894364 cites W1880198815 @default.
- W1799894364 cites W1973806783 @default.
- W1799894364 cites W1975627286 @default.
- W1799894364 cites W1978651683 @default.
- W1799894364 cites W1982324672 @default.
- W1799894364 cites W1987238214 @default.
- W1799894364 cites W1988960741 @default.
- W1799894364 cites W1990155458 @default.
- W1799894364 cites W1997158966 @default.
- W1799894364 cites W1999363813 @default.
- W1799894364 cites W2003996864 @default.
- W1799894364 cites W2005135333 @default.
- W1799894364 cites W2009717522 @default.
- W1799894364 cites W2014257368 @default.
- W1799894364 cites W2021418799 @default.
- W1799894364 cites W2028826814 @default.
- W1799894364 cites W2036143670 @default.
- W1799894364 cites W2037925122 @default.
- W1799894364 cites W2044427832 @default.
- W1799894364 cites W2049582606 @default.
- W1799894364 cites W2050714163 @default.
- W1799894364 cites W2053409748 @default.
- W1799894364 cites W2056269130 @default.
- W1799894364 cites W2057870229 @default.
- W1799894364 cites W2058863436 @default.
- W1799894364 cites W2060645146 @default.
- W1799894364 cites W2068195726 @default.
- W1799894364 cites W2075351452 @default.
- W1799894364 cites W2075806186 @default.
- W1799894364 cites W2077755865 @default.
- W1799894364 cites W2081038091 @default.
- W1799894364 cites W2081431700 @default.
- W1799894364 cites W2089530533 @default.
- W1799894364 cites W2090135185 @default.
- W1799894364 cites W2093538708 @default.
- W1799894364 cites W2123868102 @default.
- W1799894364 cites W2158067363 @default.
- W1799894364 cites W2158109323 @default.
- W1799894364 cites W2169352888 @default.
- W1799894364 cites W2401573071 @default.
- W1799894364 cites W2416645639 @default.
- W1799894364 doi "https://doi.org/10.1523/jneurosci.18-15-05928.1998" @default.
- W1799894364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6793037" @default.
- W1799894364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9671679" @default.
- W1799894364 hasPublicationYear "1998" @default.
- W1799894364 type Work @default.
- W1799894364 sameAs 1799894364 @default.
- W1799894364 citedByCount "211" @default.
- W1799894364 countsByYear W17998943642012 @default.
- W1799894364 countsByYear W17998943642013 @default.
- W1799894364 countsByYear W17998943642014 @default.
- W1799894364 countsByYear W17998943642015 @default.
- W1799894364 countsByYear W17998943642016 @default.
- W1799894364 countsByYear W17998943642017 @default.
- W1799894364 countsByYear W17998943642018 @default.
- W1799894364 countsByYear W17998943642019 @default.
- W1799894364 countsByYear W17998943642020 @default.
- W1799894364 countsByYear W17998943642021 @default.
- W1799894364 countsByYear W17998943642022 @default.
- W1799894364 countsByYear W17998943642023 @default.
- W1799894364 crossrefType "journal-article" @default.
- W1799894364 hasAuthorship W1799894364A5010308197 @default.
- W1799894364 hasAuthorship W1799894364A5023725612 @default.
- W1799894364 hasAuthorship W1799894364A5029048687 @default.
- W1799894364 hasAuthorship W1799894364A5064048333 @default.
- W1799894364 hasAuthorship W1799894364A5077494149 @default.
- W1799894364 hasAuthorship W1799894364A5084173178 @default.
- W1799894364 hasAuthorship W1799894364A5088477446 @default.
- W1799894364 hasBestOaLocation W17998943641 @default.
- W1799894364 hasConcept C126322002 @default.
- W1799894364 hasConcept C134018914 @default.
- W1799894364 hasConcept C15490471 @default.
- W1799894364 hasConcept C169760540 @default.
- W1799894364 hasConcept C170493617 @default.
- W1799894364 hasConcept C185592680 @default.
- W1799894364 hasConcept C2780775167 @default.
- W1799894364 hasConcept C40209533 @default.
- W1799894364 hasConcept C40465926 @default.
- W1799894364 hasConcept C529278444 @default.
- W1799894364 hasConcept C71924100 @default.
- W1799894364 hasConcept C86803240 @default.