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• W180033658 abstract "WHITE MATTER INTEGRITY AND AGE RELATED DIFFERENCES IN REACTION TIME COMPONENTS by YIQIN YANG December 2013 Advisor: Dr. Naftali Raz Major: Psychology Degree: Doctor of Philosophy Reduced speed in information processing is a well-documented phenomenon associated with advanced aging. Age-related deterioration in white matter integrity might play a role in age- related increase in reaction time (RT). However, the association between microstructural differences in particular white matter regions or tracts with RT is unclear. Decomposing RT into parts might be a better way to understand the relationship due to multiple processes involved in RT. In a lifespan sample of 90 healthy normotensive participants, this study examined the association between RT components derived from the Ratcliff diffusion model with age related difference in DTI indices of a wide variety of white matter tracts in both normal-appearing and whole white matter. The results revealed that advanced age was associated with lower drift rate, greater response conservativeness and longer non-decision time. Age-related reduction in FA and increase in MD was observed in most examined white matter tracts in both normal-appearing and whole white matter. Even in healthy normotensive adults, WMH burden could account for part of variance between age and DTI indices. Greater age-related difference in white matter integrity" @default.
• W180033658 created "2016-06-24" @default.
• W180033658 creator A5046252455 @default.
• W180033658 date "2013-01-01" @default.
• W180033658 modified "2023-09-27" @default.
• W180033658 title "White matter integrity and age related differences in reaction time components" @default.
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