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• W1801003313 abstract "The recognition of extracellular and cell surface carbohydrates by specific carbohydrate-binding proteins, or lectins, is an important component of many biological processes. This chapter reviews the main principles of protein-carbohydrate recognition with particular reference to examples where structural data are available and signaling is known to be important. It explores the suggestion that carbohydrate-mediated interactions provide unique cell-signaling mechanisms. The interactions between lectins and carbohydrates are relatively weak in nature and, as such, carbohydrate-mediated interactions may play important roles where weak interactions are required—the leukocyte rolling phenomenon perhaps providing a good example. In many cases, however, type II lectins have employed multivalency as a means of conferring increased affinity and specificity on their binding interactions. The structure of the asialglycoprotein receptor provides important examples of this principle. Because receptor crosslinking or clustering is a natural outcome of such multivalent interactions, it is clear that lectin-oligosaccharide interactions are inherently well suited to mediating signal transduction by the so-called horizontal mechanisms. The knowledge of lectin and glycoprotein structures shows that multivalent interactions are a recurring theme. Many lectins are oligomeric and/or membrane bound, and many glycoproteins possess multiple glycosylation sites. Their inherent ability to mediate crosslinks makes it certain that new examples of signaling roles will follow from the study of these complex and diverse molecules." @default.
• W1801003313 created "2016-06-24" @default.
• W1801003313 creator A5035332076 @default.
• W1801003313 creator A5068409365 @default.
• W1801003313 date "2010-01-01" @default.
• W1801003313 modified "2023-09-25" @default.
• W1801003313 title "Carbohydrate Recognition and Signaling" @default.
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• W1801003313 doi "https://doi.org/10.1016/b978-0-12-374145-5.00013-9" @default.
• W1801003313 hasPublicationYear "2010" @default.
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