FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1801147112> ?p ?o ?g. }

• W1801147112 endingPage "5436" @default.
• W1801147112 startingPage "5426" @default.
• W1801147112 abstract "TLRs are distributed in their characteristic cellular or subcellular compartments to efficiently recognize specific ligands and to initiate intracellular signaling. Whereas TLRs recognizing pathogen-associated lipids or proteins are localized to the cell surface, nucleic acid-sensing TLRs are expressed in endosomes and lysosomes. Several endoplasmic reticulum (ER)-resident proteins are known to regulate the trafficking of TLRs to the specific cellular compartments, thus playing important roles in the initiation of innate immune responses. In this study, we show that an ER-resident protein, Nogo-B (or RTN4-B), is necessary for immune responses triggered by nucleic acid-sensing TLRs, and that a newly identified Nogo-B-binding protein (glucosyltransferases, Rab-like GTPase activators and myotubularins [GRAM] domain containing 4 [GRAMD4]) negatively regulates the responses. Production of inflammatory cytokines in vitro by macrophages stimulated with CpG-B oligonucleotides or polyinosinic:polycytidylic acid was attenuated in the absence of Nogo-B, which was also confirmed in serum samples from Nogo-deficient mice injected with polyinosinic:polycytidylic acid. Although a deficiency of Nogo-B did not change the incorporation or delivery of CpG to endosomes, the localization of TLR9 to endolysosomes was found to be impaired. We identified GRAMD4 as a downmodulator for TLR9 response with a Nogo-B binding ability in ER, because our knockdown and overexpression experiments indicated that GRAMD4 suppresses the TLR9 response and knockdown of Gramd4 strongly enhanced the response in the absence of Nogo-B. Our findings indicate a critical role of Nogo-B and GRAMD4 in trafficking of TLR9." @default.
• W1801147112 created "2016-06-24" @default.
• W1801147112 creator A5023608401 @default.
• W1801147112 creator A5033861263 @default.
• W1801147112 creator A5037544486 @default.
• W1801147112 creator A5045382494 @default.
• W1801147112 creator A5069965100 @default.
• W1801147112 creator A5071063896 @default.
• W1801147112 date "2015-06-01" @default.
• W1801147112 modified "2023-10-04" @default.
• W1801147112 title "Endoplasmic Protein Nogo-B (RTN4-B) Interacts with GRAMD4 and Regulates TLR9-Mediated Innate Immune Responses" @default.
• W1801147112 cites W1500809101 @default.
• W1801147112 cites W1536256102 @default.
• W1801147112 cites W1566509581 @default.
• W1801147112 cites W1952053031 @default.
• W1801147112 cites W1967190456 @default.
• W1801147112 cites W1967860167 @default.
• W1801147112 cites W1968178474 @default.
• W1801147112 cites W1968643089 @default.
• W1801147112 cites W1969354039 @default.
• W1801147112 cites W1970901436 @default.
• W1801147112 cites W1971109806 @default.
• W1801147112 cites W1980073515 @default.
• W1801147112 cites W1985044548 @default.
• W1801147112 cites W1987268457 @default.
• W1801147112 cites W1987410025 @default.
• W1801147112 cites W1991024347 @default.
• W1801147112 cites W1991539783 @default.
• W1801147112 cites W1995744610 @default.
• W1801147112 cites W2003080554 @default.
• W1801147112 cites W2005423664 @default.
• W1801147112 cites W2010230342 @default.
• W1801147112 cites W2011211267 @default.
• W1801147112 cites W2022680502 @default.
• W1801147112 cites W2031364515 @default.
• W1801147112 cites W2033309880 @default.
• W1801147112 cites W2034844685 @default.
• W1801147112 cites W2035763636 @default.
• W1801147112 cites W2036064501 @default.
• W1801147112 cites W2049651968 @default.
• W1801147112 cites W2060004514 @default.
• W1801147112 cites W2061203855 @default.
• W1801147112 cites W2066388903 @default.
• W1801147112 cites W2068111737 @default.
• W1801147112 cites W2071456270 @default.
• W1801147112 cites W2082143240 @default.
• W1801147112 cites W2086766926 @default.
• W1801147112 cites W2099610218 @default.
• W1801147112 cites W2099752901 @default.
• W1801147112 cites W2105992515 @default.
• W1801147112 cites W2108587745 @default.
• W1801147112 cites W2109491705 @default.
• W1801147112 cites W2110810002 @default.
• W1801147112 cites W2112456570 @default.
• W1801147112 cites W2116611972 @default.
• W1801147112 cites W2129359803 @default.
• W1801147112 cites W2130010008 @default.
• W1801147112 cites W2132062710 @default.
• W1801147112 cites W2137053907 @default.
• W1801147112 cites W2144930705 @default.
• W1801147112 cites W2152702111 @default.
• W1801147112 cites W2154171253 @default.
• W1801147112 cites W2157839186 @default.
• W1801147112 cites W2158449767 @default.
• W1801147112 cites W2161349040 @default.
• W1801147112 cites W2167661232 @default.
• W1801147112 cites W2171907587 @default.
• W1801147112 doi "https://doi.org/10.4049/jimmunol.1402006" @default.
• W1801147112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25917084" @default.
• W1801147112 hasPublicationYear "2015" @default.
• W1801147112 type Work @default.
• W1801147112 sameAs 1801147112 @default.
• W1801147112 citedByCount "15" @default.
• W1801147112 countsByYear W18011471122016 @default.
• W1801147112 countsByYear W18011471122017 @default.
• W1801147112 countsByYear W18011471122018 @default.
• W1801147112 countsByYear W18011471122019 @default.
• W1801147112 countsByYear W18011471122020 @default.
• W1801147112 countsByYear W18011471122021 @default.
• W1801147112 countsByYear W18011471122022 @default.
• W1801147112 countsByYear W18011471122023 @default.
• W1801147112 crossrefType "journal-article" @default.
• W1801147112 hasAuthorship W1801147112A5023608401 @default.
• W1801147112 hasAuthorship W1801147112A5033861263 @default.
• W1801147112 hasAuthorship W1801147112A5037544486 @default.
• W1801147112 hasAuthorship W1801147112A5045382494 @default.
• W1801147112 hasAuthorship W1801147112A5069965100 @default.
• W1801147112 hasAuthorship W1801147112A5071063896 @default.
• W1801147112 hasBestOaLocation W18011471121 @default.
• W1801147112 hasConcept C102747710 @default.
• W1801147112 hasConcept C104317684 @default.
• W1801147112 hasConcept C136449434 @default.
• W1801147112 hasConcept C139447449 @default.
• W1801147112 hasConcept C143876685 @default.
• W1801147112 hasConcept C150194340 @default.
• W1801147112 hasConcept C158617107 @default.
• W1801147112 hasConcept C173396325 @default.
• W1801147112 hasConcept C190283241 @default.

• next