FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1801428253> ?p ?o ?g. }

• W1801428253 abstract "Moraxella catarrhalis is an important respiratory pathogen. It is a common cause of otitis media in children, a usual infections agent in sinusitis and makes up to 10% of all exacerbations of chronic obstructive pulmonary disease (COPD). It is known to cause more frequent disease in the colder season, and, generally, its importance is recognised mainly in countries exposed to moderate climate. M. catarrhalis widely colonises infants and children but it is very uncommon for the bacterium to colonise the mucosa in adults. The present thesis is concentrated on discussing two properties of M. catarrhalis, - binding and inactivation of alpha1-anticnymotrypsin (ACT) and complement component 3 (C3) for which M. catarrhalis outer membrane proteins “ubiquitous surface proteins” (Usp) A1/A2 are responsible. No other pathogenic bacterium is known to bind ACT. The ACT is a serine protease inhibitor playing important part in antiprotease lung protection and anti-inflammatory signalling. We established that M. catarrhalis is able to bind and inactivate ACT through the two active domains on both UspA1 and A2 proteins. The phenomenon is proposed to be important for a) protease-antiprotease balance in the lung, for b) exacerbating inflammation and for c) inhibition of phagocytic clearance of M. catarrhalis. The localization of ACT binding inside the UspA1 and A2 proteins provided us with means to develop a simple and quick method for purification of ACT from plasma or serum based on ACT affinity to a fragment of UspA2 protein of M. catarrhalis. The purification can be carried out practically in one step and the biological properties of ACT are retained. In the last part of the thesis the C3 binding to M. catarrhalis Usp A1 and A2 was studied. The binding has been attributed to a single fragment in the both UspA1 and A2. Importantly, C3d fragment of C3 has been found responsible for the binding to UspA1/A2. The UspA2 has been demonstrated to inhibit both the classical and the alternative pathways of the complement. The C3 binding by M. catarrhalis strongly correlated with serum resistance of the bacterium, as well as with the expression of UspA1/A2. (Less)" @default.
• W1801428253 created "2016-06-24" @default.
• W1801428253 creator A5048028259 @default.
• W1801428253 date "2009-01-01" @default.
• W1801428253 modified "2023-09-25" @default.
• W1801428253 title "The role of Moraxella catarrhalis outer membrane proteins in pathogenesis" @default.
• W1801428253 cites W1174340274 @default.
• W1801428253 cites W1175049865 @default.
• W1801428253 cites W1221909616 @default.
• W1801428253 cites W1483731773 @default.
• W1801428253 cites W1493993231 @default.
• W1801428253 cites W1495275626 @default.
• W1801428253 cites W1537083608 @default.
• W1801428253 cites W1543429526 @default.
• W1801428253 cites W1552768234 @default.
• W1801428253 cites W1560235372 @default.
• W1801428253 cites W1563535758 @default.
• W1801428253 cites W1774821796 @default.
• W1801428253 cites W1784076950 @default.
• W1801428253 cites W1821425800 @default.
• W1801428253 cites W1838448561 @default.
• W1801428253 cites W1884708982 @default.
• W1801428253 cites W1886928416 @default.
• W1801428253 cites W1892657158 @default.
• W1801428253 cites W190526261 @default.
• W1801428253 cites W1916306387 @default.
• W1801428253 cites W1940283378 @default.
• W1801428253 cites W1951559846 @default.
• W1801428253 cites W1963723016 @default.
• W1801428253 cites W1964220544 @default.
• W1801428253 cites W1972442033 @default.
• W1801428253 cites W1972556193 @default.
• W1801428253 cites W1974890290 @default.
• W1801428253 cites W1975299565 @default.
• W1801428253 cites W1981567688 @default.
• W1801428253 cites W1986028457 @default.
• W1801428253 cites W1991562522 @default.
• W1801428253 cites W1992551721 @default.
• W1801428253 cites W1993088565 @default.
• W1801428253 cites W1993307596 @default.
• W1801428253 cites W1993687314 @default.
• W1801428253 cites W2001837858 @default.
• W1801428253 cites W2003035656 @default.
• W1801428253 cites W2003422570 @default.
• W1801428253 cites W2003509030 @default.
• W1801428253 cites W2004140403 @default.
• W1801428253 cites W2007516169 @default.
• W1801428253 cites W2008737100 @default.
• W1801428253 cites W2009620784 @default.
• W1801428253 cites W2009769139 @default.
• W1801428253 cites W2012580447 @default.
• W1801428253 cites W2013576813 @default.
• W1801428253 cites W2013580369 @default.
• W1801428253 cites W2015873224 @default.
• W1801428253 cites W2017316464 @default.
• W1801428253 cites W2017383182 @default.
• W1801428253 cites W2019022540 @default.
• W1801428253 cites W2019615869 @default.
• W1801428253 cites W2021921438 @default.
• W1801428253 cites W2022512688 @default.
• W1801428253 cites W202319948 @default.
• W1801428253 cites W2023406277 @default.
• W1801428253 cites W2023993659 @default.
• W1801428253 cites W2026166106 @default.
• W1801428253 cites W2028507973 @default.
• W1801428253 cites W2037317202 @default.
• W1801428253 cites W2039141229 @default.
• W1801428253 cites W2039337154 @default.
• W1801428253 cites W2041055051 @default.
• W1801428253 cites W2041242043 @default.
• W1801428253 cites W2045723131 @default.
• W1801428253 cites W2046943185 @default.
• W1801428253 cites W2051582871 @default.
• W1801428253 cites W2053030218 @default.
• W1801428253 cites W2053998870 @default.
• W1801428253 cites W2054512902 @default.
• W1801428253 cites W2056224863 @default.
• W1801428253 cites W2056801865 @default.
• W1801428253 cites W2059408123 @default.
• W1801428253 cites W2061486920 @default.
• W1801428253 cites W2061580627 @default.
• W1801428253 cites W2062689809 @default.
• W1801428253 cites W2063056653 @default.
• W1801428253 cites W2063892429 @default.
• W1801428253 cites W2065707216 @default.
• W1801428253 cites W2067019204 @default.
• W1801428253 cites W2067673112 @default.
• W1801428253 cites W2068420419 @default.
• W1801428253 cites W2071580167 @default.
• W1801428253 cites W2072483678 @default.
• W1801428253 cites W2073115317 @default.
• W1801428253 cites W2076409217 @default.
• W1801428253 cites W2078260137 @default.
• W1801428253 cites W2081697104 @default.
• W1801428253 cites W2082876328 @default.
• W1801428253 cites W2083934313 @default.
• W1801428253 cites W2086428534 @default.
• W1801428253 cites W2087196695 @default.
• W1801428253 cites W2090583063 @default.
• W1801428253 cites W2091064122 @default.

• next