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- W1801474577 abstract "Cerebrospinal fluid (CSF) shunts carry a high risk of complications. Infections represent a major cause of shunt failure. Diagnosis and therapy of such infections are complicated by the formation of bacterial biofilms attached to shunt surfaces. This study correlated the pathophysiology and clinical course of biofilm infections with microscopical findings on the respective shunts. Surface irregularities, an important risk-factor for shunt colonisation with bacteria, were found to increase over time because of silicone degradation. Scanning electron-microscopy (SEM) documented residual biological material (dead biofilm), which can further promote extant bacterial adhesion, on newly manufactured shunts. Clinical course and SEM both documented bacterial dissemination against CSF flow and the monodirectional valve. In all cases, biofilms grew on both the inner and outer surfaces of the shunts. Microscopy and conventional culture detected all bacterial shunt infections. Analyses of 16S rDNA sequences using conserved primers identified bacteria in only one of three cases, probably because of previous formalin fixation of the samples." @default.
- W1801474577 created "2016-06-24" @default.
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- W1801474577 date "2006-04-01" @default.
- W1801474577 modified "2023-10-07" @default.
- W1801474577 title "Biofilm-related infections of cerebrospinal fluid shunts" @default.
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- W1801474577 doi "https://doi.org/10.1111/j.1469-0691.2006.01361.x" @default.
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