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• W1801503786 endingPage "883" @default.
• W1801503786 startingPage "868" @default.
• W1801503786 abstract "The citric acid or tricarboxylic acid cycle is a central element of higher‐plant carbon metabolism which provides, among other things, electrons for oxidative phosphorylation in the inner mitochondrial membrane, intermediates for amino‐acid biosynthesis, and oxaloacetate for gluconeogenesis from succinate derived from fatty acids via the glyoxylate cycle in glyoxysomes. The tricarboxylic acid cycle is a typical mitochondrial pathway and is widespread among α‐proteobacteria, the group of eubacteria as defined under rRNA systematics from which mitochondria arose. Most of the enzymes of the tricarboxylic acid cycle are encoded in the nucleus in higher eukaryotes, and several have been previously shown to branch with their homologues from α‐proteobacteria, indicating that the eukaryotic nuclear genes were acquired from the mitochondrial genome during the course of evolution. Here, we investigate the individual evolutionary histories of all of the enzymes of the tricarboxylic acid cycle and the glyoxylate cycle using protein maximum likelihood phylogenies, focusing on the evolutionary origin of the nuclear‐encoded proteins in higher plants. The results indicate that about half of the proteins involved in this eukaryotic pathway are most similar to their α‐proteobacterial homologues, whereas the remainder are most similar to eubacterial, but not specifically α‐proteobacterial, homologues. A consideration of (a) the process of lateral gene transfer among free‐living prokaryotes and (b) the mechanistics of endosymbiotic (symbiont‐to‐host) gene transfer reveals that it is unrealistic to expect all nuclear genes that were acquired from the α‐proteobacterial ancestor of mitochondria to branch specifically with their homologues encoded in the genomes of contemporary α‐proteobacteria. Rather, even if molecular phylogenetics were to work perfectly (which it does not), then some nuclear‐encoded proteins that were acquired from the α‐proteobacterial ancestor of mitochondria should, in phylogenetic trees, branch with homologues that are no longer found in most α‐proteobacterial genomes, and some should reside on long branches that reveal affinity to eubacterial rather than archaebacterial homologues, but no particular affinity for any specific eubacterial donor." @default.
• W1801503786 created "2016-06-24" @default.
• W1801503786 creator A5016571082 @default.
• W1801503786 creator A5059564941 @default.
• W1801503786 date "2002-02-01" @default.
• W1801503786 modified "2023-10-17" @default.
• W1801503786 title "Evolution of the enzymes of the citric acid cycle and the glyoxylate cycle of higher plants" @default.
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