FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1801833463> ?p ?o ?g. }

• W1801833463 endingPage "1256" @default.
• W1801833463 startingPage "1236" @default.
• W1801833463 abstract "Most vestibular nerve afferents can be classified as regularly or irregularly discharging. Two factors are theoretically identified as being potentially responsible for differences in discharge regularity. The first, ascribable to synaptic noise, is the variance (sigma v2) characterizing the transmembrane voltage fluctuations of the axon's spike trigger site, i.e., the place where impulses normally arise. The second factor is the slope (dmuv/dt) of the trigger site's postspike recovery function. Were (dmuv/dt) a major determinant of discharge regularity, the theory predicts that the more irregular the discharge of a unit, the greater should be its sensitivity to externally applied galvanic currents and the faster should be the postspike recovery of its electrical excitability. The predictions would not hold if differences in the discharge regularity between units largely reflected variations in sigma v. To test these predictions, the responses of vestibular nerve afferents to externally applied galvanic currents were studied in the barbiturate-anesthetized squirrel monkey. Current steps of 5-s duration and short (50 microsecond) shocks were delivered by way of the perilymphatic space of the vestibule. Results were similar regardless of which end organ an afferent innervated. The regularity of discharge of each unit was expressed by a normalized coefficient of variation (CV*). The galvanic sensitivity (beta p) of a unit, measured from its response to current steps, was linearly related to discharge regularity (CV*), there being approximately 20-fold variations in both variables across the afferent population. Various geometric factors--including fiber diameter, position of individual axons within the various nerve branches, and the configuration of unmyelinated processes within the sensory epithelium--are unlikely to have made a major contribution to the positive relation between beta P and CV*. The postspike recovery of electrical excitability was measured as response thresholds to shocks, synchronized to follow naturally occurring impulses at several different delays. Recovery in irregular units was more rapid than in regular units. Evidence is presented that externally applied currents acted at the spike trigger site rather than elsewhere in the sensory transduction process. We argue that the irregular discharge of some vestibular afferents offers no functional advantage in the encoding and transmission of sensory information. Rather, the irregularity of discharge is better viewed as a consequence of the enhanced sensitivity of these units to depolarizing influences, including afferent and efferent synaptic inputs." @default.
• W1801833463 created "2016-06-24" @default.
• W1801833463 creator A5006941646 @default.
• W1801833463 creator A5037587069 @default.
• W1801833463 creator A5063918241 @default.
• W1801833463 date "1984-06-01" @default.
• W1801833463 modified "2023-10-15" @default.
• W1801833463 title "Relation between discharge regularity and responses to externally applied galvanic currents in vestibular nerve afferents of the squirrel monkey" @default.
• W1801833463 doi "https://doi.org/10.1152/jn.1984.51.6.1236" @default.
• W1801833463 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6737029" @default.
• W1801833463 hasPublicationYear "1984" @default.
• W1801833463 type Work @default.
• W1801833463 sameAs 1801833463 @default.
• W1801833463 citedByCount "596" @default.
• W1801833463 countsByYear W18018334632012 @default.
• W1801833463 countsByYear W18018334632013 @default.
• W1801833463 countsByYear W18018334632014 @default.
• W1801833463 countsByYear W18018334632015 @default.
• W1801833463 countsByYear W18018334632016 @default.
• W1801833463 countsByYear W18018334632017 @default.
• W1801833463 countsByYear W18018334632018 @default.
• W1801833463 countsByYear W18018334632019 @default.
• W1801833463 countsByYear W18018334632020 @default.
• W1801833463 countsByYear W18018334632021 @default.
• W1801833463 countsByYear W18018334632022 @default.
• W1801833463 countsByYear W18018334632023 @default.
• W1801833463 crossrefType "journal-article" @default.
• W1801833463 hasAuthorship W1801833463A5006941646 @default.
• W1801833463 hasAuthorship W1801833463A5037587069 @default.
• W1801833463 hasAuthorship W1801833463A5063918241 @default.
• W1801833463 hasConcept C105702510 @default.
• W1801833463 hasConcept C121332964 @default.
• W1801833463 hasConcept C169760540 @default.
• W1801833463 hasConcept C185263204 @default.
• W1801833463 hasConcept C185592680 @default.
• W1801833463 hasConcept C190041318 @default.
• W1801833463 hasConcept C2778010927 @default.
• W1801833463 hasConcept C2778421575 @default.
• W1801833463 hasConcept C2779263132 @default.
• W1801833463 hasConcept C2779530196 @default.
• W1801833463 hasConcept C2779868778 @default.
• W1801833463 hasConcept C86803240 @default.
• W1801833463 hasConceptScore W1801833463C105702510 @default.
• W1801833463 hasConceptScore W1801833463C121332964 @default.
• W1801833463 hasConceptScore W1801833463C169760540 @default.
• W1801833463 hasConceptScore W1801833463C185263204 @default.
• W1801833463 hasConceptScore W1801833463C185592680 @default.
• W1801833463 hasConceptScore W1801833463C190041318 @default.
• W1801833463 hasConceptScore W1801833463C2778010927 @default.
• W1801833463 hasConceptScore W1801833463C2778421575 @default.
• W1801833463 hasConceptScore W1801833463C2779263132 @default.
• W1801833463 hasConceptScore W1801833463C2779530196 @default.
• W1801833463 hasConceptScore W1801833463C2779868778 @default.
• W1801833463 hasConceptScore W1801833463C86803240 @default.
• W1801833463 hasIssue "6" @default.
• W1801833463 hasLocation W18018334631 @default.
• W1801833463 hasLocation W18018334632 @default.
• W1801833463 hasOpenAccess W1801833463 @default.
• W1801833463 hasPrimaryLocation W18018334631 @default.
• W1801833463 hasRelatedWork W1970993495 @default.
• W1801833463 hasRelatedWork W1980472070 @default.
• W1801833463 hasRelatedWork W1981056649 @default.
• W1801833463 hasRelatedWork W1994599685 @default.
• W1801833463 hasRelatedWork W2017603018 @default.
• W1801833463 hasRelatedWork W2066296749 @default.
• W1801833463 hasRelatedWork W2067985560 @default.
• W1801833463 hasRelatedWork W2080874053 @default.
• W1801833463 hasRelatedWork W2084830269 @default.
• W1801833463 hasRelatedWork W2763822686 @default.
• W1801833463 hasVolume "51" @default.
• W1801833463 isParatext "false" @default.
• W1801833463 isRetracted "false" @default.
• W1801833463 magId "1801833463" @default.
• W1801833463 workType "article" @default.