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- W180194829 endingPage "iv" @default.
- W180194829 startingPage "53" @default.
- W180194829 abstract "This chapter summarizes recent findings obtained from the studies of either parathyroid hormone (PTH) ligands or receptors as single entities, and the complexes formed when PTH or PTH related protein (PTHrP) interact with the parathyroid hormone receptor (PTH1-Rc) or PTH2-Rc. To study the PTH/PTHrP-receptors system, called “ligand receptor centered” approach, first the “ligand-centered” and “receptor-centered” approaches should be studied. Studying ligands and receptors separately generates important insights. However, these concepts can only be validated when the hormone receptor bimolecular interaction is examined directly. The detailed mechanisms explain the structural changes in either hormone or receptor that can alter the hormone-receptor bimolecular interaction. The PTH-receptor system is composed of three major constituents: (1) The linear peptide hormone, (2) heptahelical transmembrane receptors, (3) heterotrimeric guanine nucleotide binding proteins (G proteins).The fully active form of PTH; a highly flexible molecule, is a linear peptide 34 amino acids long. This system is highly dynamic. The hormone has more diversified conformations when in solution than when membrane bound, and its conformation changes on interaction with the receptor. On ligand binding, the receptor may change conformation to allow global movements of transmembrane domains that leads to changes in the conformation of the cytoplasmic portions of the receptor. An insight into the nature of hormone receptor interactions reveals that the emergence of hormone receptor photoconjugates from Photo Affinity Scanning (PAS) studies. Experimental models of the bimolecular interface will be more refined and better validated." @default.
- W180194829 created "2016-06-24" @default.
- W180194829 creator A5039338616 @default.
- W180194829 creator A5070219874 @default.
- W180194829 creator A5085901971 @default.
- W180194829 date "2001-01-01" @default.
- W180194829 modified "2023-09-26" @default.
- W180194829 title "Interactions of Parathyroid Hormone and Parathyroid Hormone-Related Protein with Their Receptors" @default.
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