Matches in SemOpenAlex for { <https://semopenalex.org/work/W1802688544> ?p ?o ?g. }
- W1802688544 endingPage "269" @default.
- W1802688544 startingPage "264" @default.
- W1802688544 abstract "Alcoholic liver disease and acetaminophen overdose are common causes of severe liver disease and liver failure in the United States for which there is no cure. Therefore, development of new therapeutic strategies for treatment of liver injury caused by acetaminophen and alcohol is needed. We demonstrated that autophagy protects against alcohol and acetaminophen-induced liver injuries by removing damaged mitochondria via mitophagy, which is a selective form of autophagy specific for degradation of damaged mitochondria. Parkin is well-known to be required for mitophagy induction in in vitro models, and we previously showed that the Parkin-mediated mitophagy pathway likely plays a protective role against alcohol and acetaminophen-induced liver injuries. Therefore, pharmacological upregulation of the Parkin-mediated mitophagy pathway in the liver may provide a novel and effective therapeutic option for treatment of acetaminophen and alcohol-induced liver injuries. In this review, we discuss regulation of Parkin-mediated mitophagy and possible therapeutic targets of intervention in this pathway." @default.
- W1802688544 created "2016-06-24" @default.
- W1802688544 creator A5019633089 @default.
- W1802688544 creator A5075891734 @default.
- W1802688544 date "2015-12-01" @default.
- W1802688544 modified "2023-10-17" @default.
- W1802688544 title "Targeting Pink1-Parkin-mediated mitophagy for treating liver injury" @default.
- W1802688544 cites W1605455268 @default.
- W1802688544 cites W1770535374 @default.
- W1802688544 cites W1877873625 @default.
- W1802688544 cites W1965417951 @default.
- W1802688544 cites W1970436894 @default.
- W1802688544 cites W1983413606 @default.
- W1802688544 cites W1983470920 @default.
- W1802688544 cites W1993098682 @default.
- W1802688544 cites W1995966034 @default.
- W1802688544 cites W1996625702 @default.
- W1802688544 cites W2001648286 @default.
- W1802688544 cites W2001761748 @default.
- W1802688544 cites W2004908477 @default.
- W1802688544 cites W2013828402 @default.
- W1802688544 cites W2015758704 @default.
- W1802688544 cites W2017944969 @default.
- W1802688544 cites W2019443416 @default.
- W1802688544 cites W2019637022 @default.
- W1802688544 cites W2032476721 @default.
- W1802688544 cites W2034087770 @default.
- W1802688544 cites W2037455183 @default.
- W1802688544 cites W2038834667 @default.
- W1802688544 cites W2040470178 @default.
- W1802688544 cites W2043276141 @default.
- W1802688544 cites W2044235925 @default.
- W1802688544 cites W2047507923 @default.
- W1802688544 cites W2048984899 @default.
- W1802688544 cites W2049172731 @default.
- W1802688544 cites W2052889619 @default.
- W1802688544 cites W2053521594 @default.
- W1802688544 cites W2054556550 @default.
- W1802688544 cites W2056043482 @default.
- W1802688544 cites W2058065156 @default.
- W1802688544 cites W2067097574 @default.
- W1802688544 cites W2070463829 @default.
- W1802688544 cites W2073820873 @default.
- W1802688544 cites W2074269616 @default.
- W1802688544 cites W2076769172 @default.
- W1802688544 cites W2080806128 @default.
- W1802688544 cites W2082868693 @default.
- W1802688544 cites W2086714780 @default.
- W1802688544 cites W2089728480 @default.
- W1802688544 cites W2090711760 @default.
- W1802688544 cites W2091264505 @default.
- W1802688544 cites W2095348121 @default.
- W1802688544 cites W2097704104 @default.
- W1802688544 cites W2099875422 @default.
- W1802688544 cites W2103230459 @default.
- W1802688544 cites W2106415502 @default.
- W1802688544 cites W2113190139 @default.
- W1802688544 cites W2114787032 @default.
- W1802688544 cites W2116229231 @default.
- W1802688544 cites W2117339132 @default.
- W1802688544 cites W2129750781 @default.
- W1802688544 cites W2130979925 @default.
- W1802688544 cites W2139592339 @default.
- W1802688544 cites W2139636031 @default.
- W1802688544 cites W2140654974 @default.
- W1802688544 cites W2140679396 @default.
- W1802688544 cites W2149090315 @default.
- W1802688544 cites W2149200223 @default.
- W1802688544 cites W2155015733 @default.
- W1802688544 cites W2160330769 @default.
- W1802688544 cites W2167867141 @default.
- W1802688544 doi "https://doi.org/10.1016/j.phrs.2015.09.020" @default.
- W1802688544 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4684418" @default.
- W1802688544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26655101" @default.
- W1802688544 hasPublicationYear "2015" @default.
- W1802688544 type Work @default.
- W1802688544 sameAs 1802688544 @default.
- W1802688544 citedByCount "44" @default.
- W1802688544 countsByYear W18026885442016 @default.
- W1802688544 countsByYear W18026885442017 @default.
- W1802688544 countsByYear W18026885442018 @default.
- W1802688544 countsByYear W18026885442019 @default.
- W1802688544 countsByYear W18026885442020 @default.
- W1802688544 countsByYear W18026885442021 @default.
- W1802688544 countsByYear W18026885442022 @default.
- W1802688544 countsByYear W18026885442023 @default.
- W1802688544 crossrefType "journal-article" @default.
- W1802688544 hasAuthorship W1802688544A5019633089 @default.
- W1802688544 hasAuthorship W1802688544A5075891734 @default.
- W1802688544 hasBestOaLocation W18026885442 @default.
- W1802688544 hasConcept C126322002 @default.
- W1802688544 hasConcept C185592680 @default.
- W1802688544 hasConcept C190283241 @default.
- W1802688544 hasConcept C203522944 @default.
- W1802688544 hasConcept C2776637226 @default.
- W1802688544 hasConcept C2776804853 @default.
- W1802688544 hasConcept C2777668072 @default.
- W1802688544 hasConcept C2778722691 @default.