FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1803088394> ?p ?o ?g. }

• W1803088394 abstract "Organ site-specific metastasis is an ominous feature for most poor-prognostic hepatocellular carcinoma (HCC) patients. Cancer cell lines and animal models are indispensable for investigating the molecular mechanisms of organ specific tropism. However, till now, little is known about the drivers in HCC metastatic tropism, and also no effective way has been developed to block the process of tropistic metastasis.In this study, we established several monoclonal HCC cell lines from HCCLM3-RFP together with their xenograft models, and then analyzed their metastatic potentials and tropisms using in-vitro and in-vivo assays, and finally elucidated the driving forces of HCC tropistic metastases.Six monoclonal cell lines with different organ site-specific tropism were established successfully. SPARC, VCAM1 and ANGPTL4 were found positively correlated with the potentials of lung metastasis, while ITGA1 had a positive relation to lymph node metastasis of enterocoelia.By our powerful platforms, HCC metastatic tropisms in clinic could be easily mimicked and recapitulated for exploring the bilateral interactions between tumor and its microenvironment, elucidating the drivers of HCC metastatic tropisms, and testing anti-cancer effects of newly developed agent in pre-clinical stage." @default.
• W1803088394 created "2016-06-24" @default.
• W1803088394 creator A5002343082 @default.
• W1803088394 creator A5017352295 @default.
• W1803088394 creator A5020748598 @default.
• W1803088394 creator A5024598188 @default.
• W1803088394 creator A5029634246 @default.
• W1803088394 creator A5031759097 @default.
• W1803088394 creator A5050463894 @default.
• W1803088394 creator A5073592533 @default.
• W1803088394 creator A5074017253 @default.
• W1803088394 creator A5079615657 @default.
• W1803088394 creator A5081191891 @default.
• W1803088394 creator A5087601593 @default.
• W1803088394 date "2015-10-12" @default.
• W1803088394 modified "2023-10-17" @default.
• W1803088394 title "Establishment of monoclonal HCC cell lines with organ site-specific tropisms" @default.
• W1803088394 cites W1496148293 @default.
• W1803088394 cites W1520425169 @default.
• W1803088394 cites W1965371218 @default.
• W1803088394 cites W1967251768 @default.
• W1803088394 cites W1981328354 @default.
• W1803088394 cites W1985563073 @default.
• W1803088394 cites W1985727076 @default.
• W1803088394 cites W1998811052 @default.
• W1803088394 cites W1999050583 @default.
• W1803088394 cites W2002790336 @default.
• W1803088394 cites W2012337250 @default.
• W1803088394 cites W2031292759 @default.
• W1803088394 cites W2032600439 @default.
• W1803088394 cites W2047259303 @default.
• W1803088394 cites W2054531472 @default.
• W1803088394 cites W2057253189 @default.
• W1803088394 cites W2064231093 @default.
• W1803088394 cites W2073079990 @default.
• W1803088394 cites W2077953289 @default.
• W1803088394 cites W2082268238 @default.
• W1803088394 cites W2092868756 @default.
• W1803088394 cites W2093921289 @default.
• W1803088394 cites W2110458715 @default.
• W1803088394 cites W2137823978 @default.
• W1803088394 cites W2149146453 @default.
• W1803088394 cites W2154210454 @default.
• W1803088394 cites W2154576630 @default.
• W1803088394 cites W2164777775 @default.
• W1803088394 cites W326741768 @default.
• W1803088394 cites W4243625103 @default.
• W1803088394 doi "https://doi.org/10.1186/s12885-015-1692-0" @default.
• W1803088394 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4603809" @default.
• W1803088394 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26459277" @default.
• W1803088394 hasPublicationYear "2015" @default.
• W1803088394 type Work @default.
• W1803088394 sameAs 1803088394 @default.
• W1803088394 citedByCount "14" @default.
• W1803088394 countsByYear W18030883942017 @default.
• W1803088394 countsByYear W18030883942018 @default.
• W1803088394 countsByYear W18030883942019 @default.
• W1803088394 countsByYear W18030883942020 @default.
• W1803088394 countsByYear W18030883942021 @default.
• W1803088394 countsByYear W18030883942023 @default.
• W1803088394 crossrefType "journal-article" @default.
• W1803088394 hasAuthorship W1803088394A5002343082 @default.
• W1803088394 hasAuthorship W1803088394A5017352295 @default.
• W1803088394 hasAuthorship W1803088394A5020748598 @default.
• W1803088394 hasAuthorship W1803088394A5024598188 @default.
• W1803088394 hasAuthorship W1803088394A5029634246 @default.
• W1803088394 hasAuthorship W1803088394A5031759097 @default.
• W1803088394 hasAuthorship W1803088394A5050463894 @default.
• W1803088394 hasAuthorship W1803088394A5073592533 @default.
• W1803088394 hasAuthorship W1803088394A5074017253 @default.
• W1803088394 hasAuthorship W1803088394A5079615657 @default.
• W1803088394 hasAuthorship W1803088394A5081191891 @default.
• W1803088394 hasAuthorship W1803088394A5087601593 @default.
• W1803088394 hasBestOaLocation W18030883941 @default.
• W1803088394 hasConcept C121608353 @default.
• W1803088394 hasConcept C126322002 @default.
• W1803088394 hasConcept C142724271 @default.
• W1803088394 hasConcept C143998085 @default.
• W1803088394 hasConcept C203014093 @default.
• W1803088394 hasConcept C2522874641 @default.
• W1803088394 hasConcept C2778019345 @default.
• W1803088394 hasConcept C2779013556 @default.
• W1803088394 hasConcept C2780140570 @default.
• W1803088394 hasConcept C35693153 @default.
• W1803088394 hasConcept C502942594 @default.
• W1803088394 hasConcept C54355233 @default.
• W1803088394 hasConcept C71924100 @default.
• W1803088394 hasConcept C81885089 @default.
• W1803088394 hasConcept C86803240 @default.
• W1803088394 hasConceptScore W1803088394C121608353 @default.
• W1803088394 hasConceptScore W1803088394C126322002 @default.
• W1803088394 hasConceptScore W1803088394C142724271 @default.
• W1803088394 hasConceptScore W1803088394C143998085 @default.
• W1803088394 hasConceptScore W1803088394C203014093 @default.
• W1803088394 hasConceptScore W1803088394C2522874641 @default.
• W1803088394 hasConceptScore W1803088394C2778019345 @default.
• W1803088394 hasConceptScore W1803088394C2779013556 @default.
• W1803088394 hasConceptScore W1803088394C2780140570 @default.
• W1803088394 hasConceptScore W1803088394C35693153 @default.
• W1803088394 hasConceptScore W1803088394C502942594 @default.

• next