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• W1803258572 abstract "The formation and accumulation of toxic amyloid-β peptides (Aβ) in the brain may drive the pathogenesis of Alzheimer's disease. Accordingly, disease-modifying therapies for Alzheimer's disease and related disorders could result from treatments regulating Aβ homeostasis. Examples are the inhibition of production, misfolding, and accumulation of Aβ or the enhancement of its clearance. Here we show that oral treatment with ACI-91 (Pirenzepine) dose-dependently reduced brain Aβ burden in AβPPPS1, hAβPPSL, and AβPP/PS1 transgenic mice. A possible mechanism of action of ACI-91 may occur through selective inhibition of muscarinic acetylcholine receptors (AChR) on endothelial cells of brain microvessels and enhanced Aβ peptide clearance across the blood-brain barrier. One month treatment with ACI-91 increased the clearance of intrathecally-injected Aβ in plaque-bearing mice. ACI-91 also accelerated the clearance of brain-injected Aβ in blood and peripheral tissues by favoring its urinal excretion. A single oral dose of ACI-91 reduced the half-life of interstitial Aβ peptide in pre-plaque mhAβPP/PS1d mice. By extending our studies to an in vitro model, we showed that muscarinic AChR inhibition by ACI-91 and Darifenacin augmented the capacity of differentiated endothelial monolayers for active transport of Aβ peptide. Finally, ACI-91 was found to consistently affect, in vitro and in vivo, the expression of endothelial cell genes involved in Aβ transport across the Blood Brain Brain (BBB). Thus increased Aβ clearance through the BBB may contribute to reduced Aβ burden and associated phenotypes. Inhibition of muscarinic AChR restricted to the periphery may present a therapeutic advantage as it avoids adverse central cholinergic effects." @default.
• W1803258572 created "2016-06-24" @default.
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• W1803258572 date "2013-12-10" @default.
• W1803258572 modified "2023-09-27" @default.
• W1803258572 title "Increased Efflux of Amyloid-β Peptides through the Blood-Brain Barrier by Muscarinic Acetylcholine Receptor Inhibition Reduces Pathological Phenotypes in Mouse Models of Brain Amyloidosis" @default.
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• W1803258572 cites W1511142149 @default.
• W1803258572 cites W1572154908 @default.
• W1803258572 cites W1588345803 @default.
• W1803258572 cites W1616122655 @default.
• W1803258572 cites W1828753295 @default.
• W1803258572 cites W1929267935 @default.
• W1803258572 cites W1964314802 @default.
• W1803258572 cites W1971834278 @default.
• W1803258572 cites W1973763077 @default.
• W1803258572 cites W1975141413 @default.
• W1803258572 cites W1978504166 @default.
• W1803258572 cites W1986190676 @default.
• W1803258572 cites W1993022928 @default.
• W1803258572 cites W1997822484 @default.
• W1803258572 cites W1999959667 @default.
• W1803258572 cites W2001580754 @default.
• W1803258572 cites W2002181764 @default.
• W1803258572 cites W2005576596 @default.
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• W1803258572 cites W2011914090 @default.
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• W1803258572 cites W2026620385 @default.
• W1803258572 cites W2026935710 @default.
• W1803258572 cites W2032885546 @default.
• W1803258572 cites W2033354781 @default.
• W1803258572 cites W2041512773 @default.
• W1803258572 cites W2063471656 @default.
• W1803258572 cites W2066411956 @default.
• W1803258572 cites W2068631553 @default.
• W1803258572 cites W2079389799 @default.
• W1803258572 cites W2079593460 @default.
• W1803258572 cites W2085146964 @default.
• W1803258572 cites W2085872177 @default.
• W1803258572 cites W2089809637 @default.
• W1803258572 cites W2090064967 @default.
• W1803258572 cites W2090097368 @default.
• W1803258572 cites W2092522921 @default.
• W1803258572 cites W2095268222 @default.
• W1803258572 cites W2097116790 @default.
• W1803258572 cites W2104132043 @default.
• W1803258572 cites W2109322549 @default.
• W1803258572 cites W2117339718 @default.
• W1803258572 cites W2121645741 @default.
• W1803258572 cites W2124217561 @default.
• W1803258572 cites W2125437798 @default.
• W1803258572 cites W2129085204 @default.
• W1803258572 cites W2131180711 @default.
• W1803258572 cites W2131495383 @default.
• W1803258572 cites W2140503956 @default.
• W1803258572 cites W2141395749 @default.
• W1803258572 cites W2142123254 @default.
• W1803258572 cites W2143979909 @default.
• W1803258572 cites W2156788921 @default.
• W1803258572 cites W2157152668 @default.
• W1803258572 cites W2163209521 @default.
• W1803258572 cites W2167183660 @default.
• W1803258572 cites W2269512218 @default.
• W1803258572 cites W2295752641 @default.
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• W1803258572 doi "https://doi.org/10.3233/jad-131091" @default.
• W1803258572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24072071" @default.
• W1803258572 hasPublicationYear "2013" @default.
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