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- W1803695655 abstract "Although the nucleus is the hallmark of eukaryotic cells, we still know remarkably little about its structure and function. As a matter of fact, already in 1836 Gabriel G. Valentin described not only nuclei in neurons but also their most conspicuous structure, the nucleolus. Nuclei come in different sizes, shapes and numbers. Some eukaryotic cells have multilobed nuclei (e.g., polymorphonuclear leukocytes), others may have two or more nuclei (e.g., cardiac and skeletal now routinely used to distinguish cell types, sex and diseases. The initial discovery of a prominent mass of chromatin seen only in female cells by Murray L. Barr (1948), led to the identification of the inactive X chromosome in females and represented the beginning of a new science called human cytogenetics. For a long time, the nucleus has been underestimated as a mere repository of the genetic information packed into chromatin, freely floating like noodles in rent picture of the nucleus with many discrete and distinguishable subnuclear compartments involved in DNA or RNA metabolism (reviewed in Leonhardt and Cardoso, 1995). Studies on chromatin architecture using initially mitotic chromosomes and later, with the development of in situ hybridization techniques, also interphase chromatin indicated a high degree of organization into discrete compartments called chromosome territories (reviewed in (Cremer and Cre-" @default.
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- W1803695655 date "2003-05-01" @default.
- W1803695655 modified "2023-09-25" @default.
- W1803695655 title "Law and Order in the Nucleus" @default.
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