Matches in SemOpenAlex for { <https://semopenalex.org/work/W1804241097> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W1804241097 abstract "This thesis explores the influence of brain regions in the extended hippocampal system on the activity of the retrosplenial cortex in the rat. The primary motivation of the experiments presented in this thesis is to improve the understanding of the vulnerability of the retrosplenial cortex, especially in the context of diencephalic amnesia and Alzheimer's disease. Using molecular imaging, it is shown that discernible networks of brain regions are active even at different training levels of the same spatial memory task, not just between different tasks. I provide evidence that multiple brain regions exhibit a relationship with memory. Importantly, these regions display associations with different memory components, which change according to the experience and the performance level of the subjects. The lesion studies provide information about the vulnerability of granular b retrosplenial cortex to distal damage in certain regions. The pattern of the terminations of the projections from each region to the retrosplenial cortex does not appear to be predictive of the impact that damage to each will have on immediate-early gene activity in the latter. In addition to the anterior thalamic nuclei, the retrosplenial cortex is vulnerable to damage in the entorhinal cortex and in the hippocampus, but not in the laterodorsal thalamic nucleus. I show that retrosplenial cortex dysfunction can occur as early as one week after anterior thalamic nuclei lesions. Evidence is also shown to suggest that both granular and dysgranular subregions of the retrosplenial cortex are affected as a result of anterior thalamic nuclei lesions. Finally, the presence of hormonal alterations in dysfunctional retrosplenial cortex tissue and evidence from a microarray analysis suggest that this region exhibits widespread alterations in cellular function after anterior thalamic nuclei lesions. The effects presented and the mechanisms that are proposed contribute to our understanding of the vulnerability of the retrosplenial cortex to neurological insults." @default.
- W1804241097 created "2016-06-24" @default.
- W1804241097 creator A5028985514 @default.
- W1804241097 date "2006-01-01" @default.
- W1804241097 modified "2023-09-24" @default.
- W1804241097 title "Sensitivity of the retrosplenial cortex to distal damage in a network associated with spatial memory : evidence from lesion and gene expression studies in the rat" @default.
- W1804241097 hasPublicationYear "2006" @default.
- W1804241097 type Work @default.
- W1804241097 sameAs 1804241097 @default.
- W1804241097 citedByCount "0" @default.
- W1804241097 crossrefType "dissertation" @default.
- W1804241097 hasAuthorship W1804241097A5028985514 @default.
- W1804241097 hasConcept C118552586 @default.
- W1804241097 hasConcept C148762608 @default.
- W1804241097 hasConcept C151730666 @default.
- W1804241097 hasConcept C15744967 @default.
- W1804241097 hasConcept C169760540 @default.
- W1804241097 hasConcept C2777348757 @default.
- W1804241097 hasConcept C2779343474 @default.
- W1804241097 hasConcept C2780200011 @default.
- W1804241097 hasConcept C2780715579 @default.
- W1804241097 hasConcept C2781041448 @default.
- W1804241097 hasConcept C2781156865 @default.
- W1804241097 hasConcept C2781161787 @default.
- W1804241097 hasConcept C86803240 @default.
- W1804241097 hasConceptScore W1804241097C118552586 @default.
- W1804241097 hasConceptScore W1804241097C148762608 @default.
- W1804241097 hasConceptScore W1804241097C151730666 @default.
- W1804241097 hasConceptScore W1804241097C15744967 @default.
- W1804241097 hasConceptScore W1804241097C169760540 @default.
- W1804241097 hasConceptScore W1804241097C2777348757 @default.
- W1804241097 hasConceptScore W1804241097C2779343474 @default.
- W1804241097 hasConceptScore W1804241097C2780200011 @default.
- W1804241097 hasConceptScore W1804241097C2780715579 @default.
- W1804241097 hasConceptScore W1804241097C2781041448 @default.
- W1804241097 hasConceptScore W1804241097C2781156865 @default.
- W1804241097 hasConceptScore W1804241097C2781161787 @default.
- W1804241097 hasConceptScore W1804241097C86803240 @default.
- W1804241097 hasLocation W18042410971 @default.
- W1804241097 hasOpenAccess W1804241097 @default.
- W1804241097 hasPrimaryLocation W18042410971 @default.
- W1804241097 hasRelatedWork W1603824339 @default.
- W1804241097 hasRelatedWork W1901008940 @default.
- W1804241097 hasRelatedWork W1956265636 @default.
- W1804241097 hasRelatedWork W2035910246 @default.
- W1804241097 hasRelatedWork W2037407575 @default.
- W1804241097 hasRelatedWork W2059629706 @default.
- W1804241097 hasRelatedWork W2061720501 @default.
- W1804241097 hasRelatedWork W2078088488 @default.
- W1804241097 hasRelatedWork W2080407903 @default.
- W1804241097 hasRelatedWork W2221202958 @default.
- W1804241097 hasRelatedWork W2227039809 @default.
- W1804241097 hasRelatedWork W2314112068 @default.
- W1804241097 hasRelatedWork W2414808590 @default.
- W1804241097 hasRelatedWork W2727278441 @default.
- W1804241097 hasRelatedWork W2885008803 @default.
- W1804241097 hasRelatedWork W2963884560 @default.
- W1804241097 hasRelatedWork W3092820417 @default.
- W1804241097 hasRelatedWork W3111505231 @default.
- W1804241097 hasRelatedWork W3136962094 @default.
- W1804241097 hasRelatedWork W3012353521 @default.
- W1804241097 isParatext "false" @default.
- W1804241097 isRetracted "false" @default.
- W1804241097 magId "1804241097" @default.
- W1804241097 workType "dissertation" @default.