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- W180438132 abstract "Sequences of the entire human genome reveal a relative richness in structure with repetitive elements, tandem repeats, inverted repeats, and palindrome structures. Focusing on structure, the evolution of X and Y chromosomes in primates is reviewed here, and the relationship between gene expression and gene structure on autosomes is explored. In a four-stratum scenario of mammalian sex chromosome evolution, a region of exceptionally low sequence divergence has been identified, and the reasons for this low sequence divergence are presented here. In addition, the construction of palindromes on the human Y chromosome is discussed in relationship to the emergence of genes in the male-specific region on the Y chromosome. Based on these observations, six of eight palindromes on the human Y chromosome are considered to have formed before the divergence of Old World monkeys and hominoids. The relationship between gene expression patterns and copy number variation illustrates the role of negative selection in the retention of high copy number to maintain the coordination of gene expression in a network of gene expression." @default.
- W180438132 created "2016-06-24" @default.
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- W180438132 date "2011-12-19" @default.
- W180438132 modified "2023-09-24" @default.
- W180438132 title "Genome Structure and Primate Evolution" @default.
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- W180438132 doi "https://doi.org/10.1007/978-4-431-54011-3_10" @default.
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