FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1804641419> ?p ?o ?g. }

• W1804641419 endingPage "619" @default.
• W1804641419 startingPage "611" @default.
• W1804641419 abstract "To assess the role of circulating immune complexes in the pathogenesis of acute rejection, sera were measured for such complexes by the (125)I-C1(q) binding assay in 45 normal subjects, 24 allografted patients undergoing acute rejection, and in 11 allografted patients in a quiescent phase. Increased C1(q)-binding activity (C1(q)-BA) was detected in 14 patients with acute rejection, 9 of whom had renal biopsies showing fibrin deposition in the vasculature together with cellular infiltrates in the tubulo-interstitial structures; renal histology was not available in the other 5 patients. The other 10 patients with acute rejection, whose biopsies showed only cellular infiltrates, and the 11 patients in a quiescent phase posttransplantation did not have increased levels of serum C1(q)-BA. Of the group with increased serum C1(q)-BA, serial studies in eight patients showed a correlation between increased serum C1(q)-BA and the occurrence of rejection; with reversal by therapy, serum C1(q)-BA returned to within normal levels. Complexes from six patients were analyzed by sucrose density gradient ultracentrifugation to have sedimentation coefficients ranging from 15S to 18.4S. After acid dissociation and analysis by double-diffusion techniques, C1(q)-reactive complexes were shown to contain IgG. Immunofluorescent studies done in five renal biopsies from this group revealed granular deposits of immunoglobulin, and (or) less frequently, of complement in the glomeruli or the tubular basement membranes. The findings suggest that circulating immune complexes may mediate the type of acute rejection characterized by fibrin deposition in the kidney. The role of circulating immune complexes arising from the recipient's original kidney disease could be excluded in 10 patients with humoral rejection, inasmuch as the underlying renal pathology was of a nonimmunologic nature; this was corroborated by sequential studies in six patients in whom circulating immune complexes could not be demonstrated before rejection. The participation of administered antilymphocyte globulin (ALG) as an antigen also appears to be excluded in four patients, two who were not given ALG, and in two of whom episodes of rejection occurred unrelated temporally to ALG administration." @default.
• W1804641419 created "2016-06-24" @default.
• W1804641419 creator A5019718174 @default.
• W1804641419 creator A5026208455 @default.
• W1804641419 creator A5027481862 @default.
• W1804641419 creator A5038010072 @default.
• W1804641419 creator A5068918816 @default.
• W1804641419 date "1977-09-01" @default.
• W1804641419 modified "2023-09-26" @default.
• W1804641419 title "Circulating Immune Complexes after Renal Transplantation" @default.
• W1804641419 cites W1521700725 @default.
• W1804641419 cites W1548060716 @default.
• W1804641419 cites W1770836413 @default.
• W1804641419 cites W1783506013 @default.
• W1804641419 cites W1979728643 @default.
• W1804641419 cites W2000423828 @default.
• W1804641419 cites W2010445968 @default.
• W1804641419 cites W2019431458 @default.
• W1804641419 cites W2031407104 @default.
• W1804641419 cites W2062192514 @default.
• W1804641419 cites W2071722003 @default.
• W1804641419 cites W2092095372 @default.
• W1804641419 cites W2120921604 @default.
• W1804641419 cites W2150088335 @default.
• W1804641419 cites W2212227232 @default.
• W1804641419 cites W2260260414 @default.
• W1804641419 cites W2315085743 @default.
• W1804641419 cites W2401647468 @default.
• W1804641419 doi "https://doi.org/10.1172/jci108812" @default.
• W1804641419 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/372405" @default.
• W1804641419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/330564" @default.
• W1804641419 hasPublicationYear "1977" @default.
• W1804641419 type Work @default.
• W1804641419 sameAs 1804641419 @default.
• W1804641419 citedByCount "36" @default.
• W1804641419 crossrefType "journal-article" @default.
• W1804641419 hasAuthorship W1804641419A5019718174 @default.
• W1804641419 hasAuthorship W1804641419A5026208455 @default.
• W1804641419 hasAuthorship W1804641419A5027481862 @default.
• W1804641419 hasAuthorship W1804641419A5038010072 @default.
• W1804641419 hasAuthorship W1804641419A5068918816 @default.
• W1804641419 hasBestOaLocation W18046414191 @default.
• W1804641419 hasConcept C126322002 @default.
• W1804641419 hasConcept C142724271 @default.
• W1804641419 hasConcept C159654299 @default.
• W1804641419 hasConcept C185592680 @default.
• W1804641419 hasConcept C203014093 @default.
• W1804641419 hasConcept C2778474638 @default.
• W1804641419 hasConcept C2780091579 @default.
• W1804641419 hasConcept C2780942790 @default.
• W1804641419 hasConcept C2911091166 @default.
• W1804641419 hasConcept C54173615 @default.
• W1804641419 hasConcept C71924100 @default.
• W1804641419 hasConcept C8891405 @default.
• W1804641419 hasConceptScore W1804641419C126322002 @default.
• W1804641419 hasConceptScore W1804641419C142724271 @default.
• W1804641419 hasConceptScore W1804641419C159654299 @default.
• W1804641419 hasConceptScore W1804641419C185592680 @default.
• W1804641419 hasConceptScore W1804641419C203014093 @default.
• W1804641419 hasConceptScore W1804641419C2778474638 @default.
• W1804641419 hasConceptScore W1804641419C2780091579 @default.
• W1804641419 hasConceptScore W1804641419C2780942790 @default.
• W1804641419 hasConceptScore W1804641419C2911091166 @default.
• W1804641419 hasConceptScore W1804641419C54173615 @default.
• W1804641419 hasConceptScore W1804641419C71924100 @default.
• W1804641419 hasConceptScore W1804641419C8891405 @default.
• W1804641419 hasIssue "3" @default.
• W1804641419 hasLocation W18046414191 @default.
• W1804641419 hasLocation W18046414192 @default.
• W1804641419 hasLocation W18046414193 @default.
• W1804641419 hasLocation W18046414194 @default.
• W1804641419 hasOpenAccess W1804641419 @default.
• W1804641419 hasPrimaryLocation W18046414191 @default.
• W1804641419 hasRelatedWork W1545962866 @default.
• W1804641419 hasRelatedWork W1572283981 @default.
• W1804641419 hasRelatedWork W1655934676 @default.
• W1804641419 hasRelatedWork W1967114480 @default.
• W1804641419 hasRelatedWork W2103136465 @default.
• W1804641419 hasRelatedWork W2320079648 @default.
• W1804641419 hasRelatedWork W2411114470 @default.
• W1804641419 hasRelatedWork W3030458261 @default.
• W1804641419 hasRelatedWork W3048051248 @default.
• W1804641419 hasRelatedWork W4200563690 @default.
• W1804641419 hasVolume "60" @default.
• W1804641419 isParatext "false" @default.
• W1804641419 isRetracted "false" @default.
• W1804641419 magId "1804641419" @default.
• W1804641419 workType "article" @default.