Matches in SemOpenAlex for { <https://semopenalex.org/work/W1804847573> ?p ?o ?g. }
- W1804847573 endingPage "C839" @default.
- W1804847573 startingPage "C833" @default.
- W1804847573 abstract "An elevation in inorganic phosphate (P(i)) concentration activates epiphyseal chondrocyte apoptosis. To determine the mechanism of apoptosis, tibial chondrocytes were treated with P(i), and nitrate/nitrite (NO/NO) levels were determined. P(i) induced a threefold increase in the NO/NO concentration; inhibitors of nitric oxide (NO) synthase activity and P(i) transport significantly reduced NO/NO levels and prevented cell death. Furthermore, a dose-dependent increase in cell death was observed after exposure of chondrocytes to S-nitrosoglutathione. P(i) increased caspase 3 activity 2.7-fold. Both caspase 1 and caspase 3 inhibitors protected chondrocytes from P(i)-induced apoptosis. P(i) caused a significant decrease in the mitochondrial membrane potential, while NO synthase inhibitors maintained mitochondrial function. While P(i) caused thiol depletion, inhibition of P(i) uptake or NO generation served to maintain glutathione levels. The results suggest that NO serves to mediate key metabolic events linked to P(i)-dependent chondrocyte apoptosis." @default.
- W1804847573 created "2016-06-24" @default.
- W1804847573 creator A5019521528 @default.
- W1804847573 creator A5039540641 @default.
- W1804847573 creator A5055821313 @default.
- W1804847573 creator A5057575401 @default.
- W1804847573 creator A5059642352 @default.
- W1804847573 date "2001-09-01" @default.
- W1804847573 modified "2023-10-18" @default.
- W1804847573 title "Phosphate-induced chondrocyte apoptosis is linked to nitric oxide generation" @default.
- W1804847573 cites W186823696 @default.
- W1804847573 cites W1981289966 @default.
- W1804847573 cites W1981397556 @default.
- W1804847573 cites W1991040567 @default.
- W1804847573 cites W1997892364 @default.
- W1804847573 cites W2007904889 @default.
- W1804847573 cites W2008563659 @default.
- W1804847573 cites W2009627704 @default.
- W1804847573 cites W2011557116 @default.
- W1804847573 cites W2013395096 @default.
- W1804847573 cites W2023920419 @default.
- W1804847573 cites W2028546937 @default.
- W1804847573 cites W2032981028 @default.
- W1804847573 cites W2033529194 @default.
- W1804847573 cites W2034946903 @default.
- W1804847573 cites W2039045136 @default.
- W1804847573 cites W2055150344 @default.
- W1804847573 cites W2064407029 @default.
- W1804847573 cites W2068147094 @default.
- W1804847573 cites W2071557165 @default.
- W1804847573 cites W2076124703 @default.
- W1804847573 cites W2079903643 @default.
- W1804847573 cites W2080801901 @default.
- W1804847573 cites W2098770709 @default.
- W1804847573 cites W2099931271 @default.
- W1804847573 cites W2103461739 @default.
- W1804847573 cites W2107366065 @default.
- W1804847573 cites W2114918609 @default.
- W1804847573 cites W2132684361 @default.
- W1804847573 cites W2139836058 @default.
- W1804847573 cites W2146497928 @default.
- W1804847573 cites W2159840477 @default.
- W1804847573 cites W2165867392 @default.
- W1804847573 cites W2171289093 @default.
- W1804847573 cites W2182275709 @default.
- W1804847573 cites W2218172750 @default.
- W1804847573 cites W2219120320 @default.
- W1804847573 cites W2253572376 @default.
- W1804847573 cites W2407586722 @default.
- W1804847573 cites W356031423 @default.
- W1804847573 cites W4236608613 @default.
- W1804847573 cites W2080522924 @default.
- W1804847573 doi "https://doi.org/10.1152/ajpcell.2001.281.3.c833" @default.
- W1804847573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11502560" @default.
- W1804847573 hasPublicationYear "2001" @default.
- W1804847573 type Work @default.
- W1804847573 sameAs 1804847573 @default.
- W1804847573 citedByCount "60" @default.
- W1804847573 countsByYear W18048475732012 @default.
- W1804847573 countsByYear W18048475732013 @default.
- W1804847573 countsByYear W18048475732015 @default.
- W1804847573 countsByYear W18048475732016 @default.
- W1804847573 countsByYear W18048475732017 @default.
- W1804847573 countsByYear W18048475732018 @default.
- W1804847573 countsByYear W18048475732019 @default.
- W1804847573 countsByYear W18048475732020 @default.
- W1804847573 countsByYear W18048475732021 @default.
- W1804847573 countsByYear W18048475732023 @default.
- W1804847573 crossrefType "journal-article" @default.
- W1804847573 hasAuthorship W1804847573A5019521528 @default.
- W1804847573 hasAuthorship W1804847573A5039540641 @default.
- W1804847573 hasAuthorship W1804847573A5055821313 @default.
- W1804847573 hasAuthorship W1804847573A5057575401 @default.
- W1804847573 hasAuthorship W1804847573A5059642352 @default.
- W1804847573 hasConcept C178790620 @default.
- W1804847573 hasConcept C181199279 @default.
- W1804847573 hasConcept C185592680 @default.
- W1804847573 hasConcept C190283241 @default.
- W1804847573 hasConcept C202751555 @default.
- W1804847573 hasConcept C2777622882 @default.
- W1804847573 hasConcept C2781403057 @default.
- W1804847573 hasConcept C28859421 @default.
- W1804847573 hasConcept C31573885 @default.
- W1804847573 hasConcept C519581460 @default.
- W1804847573 hasConcept C538909803 @default.
- W1804847573 hasConcept C55493867 @default.
- W1804847573 hasConcept C86803240 @default.
- W1804847573 hasConcept C95444343 @default.
- W1804847573 hasConcept C98424977 @default.
- W1804847573 hasConceptScore W1804847573C178790620 @default.
- W1804847573 hasConceptScore W1804847573C181199279 @default.
- W1804847573 hasConceptScore W1804847573C185592680 @default.
- W1804847573 hasConceptScore W1804847573C190283241 @default.
- W1804847573 hasConceptScore W1804847573C202751555 @default.
- W1804847573 hasConceptScore W1804847573C2777622882 @default.
- W1804847573 hasConceptScore W1804847573C2781403057 @default.
- W1804847573 hasConceptScore W1804847573C28859421 @default.
- W1804847573 hasConceptScore W1804847573C31573885 @default.