Matches in SemOpenAlex for { <https://semopenalex.org/work/W180507913> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W180507913 endingPage "1018" @default.
- W180507913 startingPage "1018" @default.
- W180507913 abstract "Sir,We read with great interest the article by Tahergorabi et al. on “Ghrelin does not modulate angiogenesis in matrigel plug (BD Biosciences) in normal and diet-induced obese mice” published in “Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences Caspian Journal of Internal Medicine.”[1] Tahergorabi et al. reported some interesting results based mostly on statistical associations that, there was a strong positive correlation between the number of CD31-positive cells and serum leptin concentration (r = 0.91). However, we think that some points should be discussed.Angiogenesis is a very complex process containing many angiogenic and antiangiogenic factors. The subcutaneous matrigel plug assay in mice is a method of choice for the in vivo evaluation of pro- and antiangiogenic molecules. Matrigel containing test cells or substances is injected subcutaneously, where it solidifies to form a plug. This plug can be recovered after 7-21 days in the animal and examined histologically to determine the extent to which blood vessels have entered it.[2,3,4]In this study, matrigel plugs were removed after 10-day from administration and at the same time systemic serum leptin levels was measured and a strong positive correlation between the number of CD31-positive cells in the matrigel plug with leptin and serum leptin levels (r = 0.91; P < 0.05) was reported. The comparison of systemic serum leptin levels and CD31-positive cells in the matrigel plug (local administration) is not suitable for statically. If the leptin levels were measured before and after matrigel administration, it should have been more meaningful. Because 10-day application of matrigel plug with leptin can’t affect the systemic leptin results. In addition, as shown in recent studies, high fat diet-induced obesity causes increasing in leptin levels.[5]In conclusion, it would be appreciated if the authors could present some more data adjusted for major confounders." @default.
- W180507913 created "2016-06-24" @default.
- W180507913 creator A5033822939 @default.
- W180507913 creator A5037137608 @default.
- W180507913 creator A5058696593 @default.
- W180507913 creator A5073404207 @default.
- W180507913 date "2014-10-01" @default.
- W180507913 modified "2023-10-16" @default.
- W180507913 title "The deficits of matrigel plug assay." @default.
- W180507913 cites W2040343009 @default.
- W180507913 cites W2055406098 @default.
- W180507913 cites W2074818613 @default.
- W180507913 cites W2140705491 @default.
- W180507913 cites W2157118250 @default.
- W180507913 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4274563" @default.
- W180507913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25538790" @default.
- W180507913 hasPublicationYear "2014" @default.
- W180507913 type Work @default.
- W180507913 sameAs 180507913 @default.
- W180507913 citedByCount "0" @default.
- W180507913 crossrefType "journal-article" @default.
- W180507913 hasAuthorship W180507913A5033822939 @default.
- W180507913 hasAuthorship W180507913A5037137608 @default.
- W180507913 hasAuthorship W180507913A5058696593 @default.
- W180507913 hasAuthorship W180507913A5073404207 @default.
- W180507913 hasConcept C126322002 @default.
- W180507913 hasConcept C134018914 @default.
- W180507913 hasConcept C142724271 @default.
- W180507913 hasConcept C150903083 @default.
- W180507913 hasConcept C207001950 @default.
- W180507913 hasConcept C2776390293 @default.
- W180507913 hasConcept C2778271429 @default.
- W180507913 hasConcept C2778608917 @default.
- W180507913 hasConcept C2778939058 @default.
- W180507913 hasConcept C2780394083 @default.
- W180507913 hasConcept C2780613262 @default.
- W180507913 hasConcept C2986115478 @default.
- W180507913 hasConcept C511355011 @default.
- W180507913 hasConcept C71924100 @default.
- W180507913 hasConcept C86803240 @default.
- W180507913 hasConceptScore W180507913C126322002 @default.
- W180507913 hasConceptScore W180507913C134018914 @default.
- W180507913 hasConceptScore W180507913C142724271 @default.
- W180507913 hasConceptScore W180507913C150903083 @default.
- W180507913 hasConceptScore W180507913C207001950 @default.
- W180507913 hasConceptScore W180507913C2776390293 @default.
- W180507913 hasConceptScore W180507913C2778271429 @default.
- W180507913 hasConceptScore W180507913C2778608917 @default.
- W180507913 hasConceptScore W180507913C2778939058 @default.
- W180507913 hasConceptScore W180507913C2780394083 @default.
- W180507913 hasConceptScore W180507913C2780613262 @default.
- W180507913 hasConceptScore W180507913C2986115478 @default.
- W180507913 hasConceptScore W180507913C511355011 @default.
- W180507913 hasConceptScore W180507913C71924100 @default.
- W180507913 hasConceptScore W180507913C86803240 @default.
- W180507913 hasIssue "10" @default.
- W180507913 hasLocation W1805079131 @default.
- W180507913 hasOpenAccess W180507913 @default.
- W180507913 hasPrimaryLocation W1805079131 @default.
- W180507913 hasRelatedWork W117224801 @default.
- W180507913 hasRelatedWork W1614368297 @default.
- W180507913 hasRelatedWork W2057575752 @default.
- W180507913 hasRelatedWork W2064029199 @default.
- W180507913 hasRelatedWork W2091381562 @default.
- W180507913 hasRelatedWork W2284115326 @default.
- W180507913 hasRelatedWork W2612264023 @default.
- W180507913 hasRelatedWork W3125743648 @default.
- W180507913 hasRelatedWork W3178171265 @default.
- W180507913 hasRelatedWork W3032437276 @default.
- W180507913 hasVolume "19" @default.
- W180507913 isParatext "false" @default.
- W180507913 isRetracted "false" @default.
- W180507913 magId "180507913" @default.
- W180507913 workType "article" @default.