FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1805344039> ?p ?o ?g. }

• W1805344039 endingPage "3346" @default.
• W1805344039 startingPage "3338" @default.
• W1805344039 abstract "PURPOSE To evaluate the efficacy and toxicity of mechlorethamine, vincristine, procarbazine, and prednisone (MOPP)/doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) chemotherapy plus mantle-field radiation therapy in the treatment of patients with massive mediastinal Hodgkin's disease of any stage. PATIENTS AND METHODS Eighty patients presented with Hodgkin's disease and a mediastinal mass greater than one third the greatest chest diameter on chest radiograph. Patients were staged and treated with MOPP alternated with ABVD chemotherapy for a total of six cycles. Patients then received 10 Gy mantle-field radiation therapy delivered to the original extent of disease followed by 25 to 35 Gy to the residual abnormalities. RESULTS The complete response (CR) rate was 89%. With a median follow-up duration of 10 years, disease-free survival of the complete responders is 78% at 15 years and overall survival is 75% at 15 years. For patients with stage I or II disease, disease-free survival was 76% at 15 years and overall survival was 79%; for those with stage III or IV disease, disease-free survival was 82% at 15 years and overall survival was 64%. Age, stage, sex, B symptoms, number of extranodal sites, lactate dehydrogenase (LDH) levels, erythrocyte sedimentation rate, and platelet count did not influence treatment outcome. Treatment-related pneumonitis was noted in 16% of patients (fatal in one), mainly in those older than age 35 years who received total doses of radiation therapy greater than 42 Gy. Fertility is more often preserved with MOPP/ABVD therapy than with MOPP chemotherapy and there appears to be less pulmonary and cardiac disease than with ABVD chemotherapy. Two patients have developed second solid tumors within radiation ports and one relapsed patient developed acute leukemia after MOPP salvage therapy. CONCLUSION MOPP/ABVD followed by mantle-field radiation therapy is an effective treatment for all stages of Hodgkin's disease that present with a large mediastinal mass. Our data suggest that the large mediastinal mass is a more dominant determinant of prognosis than Ann Arbor stage or other clinical prognostic factors." @default.
• W1805344039 created "2016-06-24" @default.
• W1805344039 creator A5002920422 @default.
• W1805344039 creator A5013858752 @default.
• W1805344039 creator A5025992852 @default.
• W1805344039 creator A5038738545 @default.
• W1805344039 creator A5039707350 @default.
• W1805344039 creator A5061586043 @default.
• W1805344039 creator A5069889922 @default.
• W1805344039 creator A5071917086 @default.
• W1805344039 creator A5080492142 @default.
• W1805344039 creator A5086638104 @default.
• W1805344039 creator A5089779163 @default.
• W1805344039 date "1997-11-01" @default.
• W1805344039 modified "2023-09-25" @default.
• W1805344039 title "Alternating MOPP and ABVD chemotherapy plus mantle-field radiation therapy in patients with massive mediastinal Hodgkin's disease." @default.
• W1805344039 cites W1856398768 @default.
• W1805344039 cites W1917085797 @default.
• W1805344039 cites W1944099139 @default.
• W1805344039 cites W1965965711 @default.
• W1805344039 cites W1971293000 @default.
• W1805344039 cites W1975163162 @default.
• W1805344039 cites W1979128420 @default.
• W1805344039 cites W1979300931 @default.
• W1805344039 cites W1995855167 @default.
• W1805344039 cites W2009608385 @default.
• W1805344039 cites W2014698797 @default.
• W1805344039 cites W2031335625 @default.
• W1805344039 cites W2041629407 @default.
• W1805344039 cites W2047569501 @default.
• W1805344039 cites W2055558717 @default.
• W1805344039 cites W2092248185 @default.
• W1805344039 cites W2139984188 @default.
• W1805344039 cites W2322312023 @default.
• W1805344039 cites W2341591060 @default.
• W1805344039 cites W2407538090 @default.
• W1805344039 cites W2470495198 @default.
• W1805344039 cites W3143935566 @default.
• W1805344039 cites W5832496 @default.
• W1805344039 cites W866264 @default.
• W1805344039 doi "https://doi.org/10.1200/jco.1997.15.11.3338" @default.
• W1805344039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9363863" @default.
• W1805344039 hasPublicationYear "1997" @default.
• W1805344039 type Work @default.
• W1805344039 sameAs 1805344039 @default.
• W1805344039 citedByCount "43" @default.
• W1805344039 countsByYear W18053440392012 @default.
• W1805344039 countsByYear W18053440392014 @default.
• W1805344039 countsByYear W18053440392016 @default.
• W1805344039 countsByYear W18053440392020 @default.
• W1805344039 countsByYear W18053440392023 @default.
• W1805344039 crossrefType "journal-article" @default.
• W1805344039 hasAuthorship W1805344039A5002920422 @default.
• W1805344039 hasAuthorship W1805344039A5013858752 @default.
• W1805344039 hasAuthorship W1805344039A5025992852 @default.
• W1805344039 hasAuthorship W1805344039A5038738545 @default.
• W1805344039 hasAuthorship W1805344039A5039707350 @default.
• W1805344039 hasAuthorship W1805344039A5061586043 @default.
• W1805344039 hasAuthorship W1805344039A5069889922 @default.
• W1805344039 hasAuthorship W1805344039A5071917086 @default.
• W1805344039 hasAuthorship W1805344039A5080492142 @default.
• W1805344039 hasAuthorship W1805344039A5086638104 @default.
• W1805344039 hasAuthorship W1805344039A5089779163 @default.
• W1805344039 hasConcept C126322002 @default.
• W1805344039 hasConcept C141071460 @default.
• W1805344039 hasConcept C2776305933 @default.
• W1805344039 hasConcept C2776694085 @default.
• W1805344039 hasConcept C2776755627 @default.
• W1805344039 hasConcept C2777132456 @default.
• W1805344039 hasConcept C2779112685 @default.
• W1805344039 hasConcept C2779429289 @default.
• W1805344039 hasConcept C2780964509 @default.
• W1805344039 hasConcept C509974204 @default.
• W1805344039 hasConcept C71924100 @default.
• W1805344039 hasConceptScore W1805344039C126322002 @default.
• W1805344039 hasConceptScore W1805344039C141071460 @default.
• W1805344039 hasConceptScore W1805344039C2776305933 @default.
• W1805344039 hasConceptScore W1805344039C2776694085 @default.
• W1805344039 hasConceptScore W1805344039C2776755627 @default.
• W1805344039 hasConceptScore W1805344039C2777132456 @default.
• W1805344039 hasConceptScore W1805344039C2779112685 @default.
• W1805344039 hasConceptScore W1805344039C2779429289 @default.
• W1805344039 hasConceptScore W1805344039C2780964509 @default.
• W1805344039 hasConceptScore W1805344039C509974204 @default.
• W1805344039 hasConceptScore W1805344039C71924100 @default.
• W1805344039 hasIssue "11" @default.
• W1805344039 hasLocation W18053440391 @default.
• W1805344039 hasLocation W18053440392 @default.
• W1805344039 hasOpenAccess W1805344039 @default.
• W1805344039 hasPrimaryLocation W18053440391 @default.
• W1805344039 hasRelatedWork W141689507 @default.
• W1805344039 hasRelatedWork W1827095708 @default.
• W1805344039 hasRelatedWork W2019922408 @default.
• W1805344039 hasRelatedWork W2055310422 @default.
• W1805344039 hasRelatedWork W2058793701 @default.
• W1805344039 hasRelatedWork W2068580551 @default.
• W1805344039 hasRelatedWork W2171380046 @default.
• W1805344039 hasRelatedWork W2417943760 @default.

• next