Matches in SemOpenAlex for { <https://semopenalex.org/work/W1805450185> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W1805450185 endingPage "1479" @default.
- W1805450185 startingPage "1479" @default.
- W1805450185 abstract "The aim of this study was to screen target genes and gene functions of androgen receptor (AR) in LNCaP cell line by ChIP-seq data analysis. We downloaded the gene expression profile GSE14092 from Gene Expression Omnibus database and selected ChIP-seq data (GSM353644) of AR stimulated by androgen R1881 (R1881 stimulation group) and the ChIP-seq data (GSM353643) of AR without R1881 stimulation (control group). MACS peak calling software was used to identify the AR binding cites. After target genes selection and function analysis, motif finding analysis was utilized to predict the AR co-located transcription regulation factors, and we analyzed their functions through GO enrichment analysis. Total 27202 and 2730 AR binding sites were detected in the R1881 stimulation group and the control group, respectively and 398 and 58 target genes were identified in R1881 stimulation group and control group, respectively. Based on GO enrichment analysis, 20 biological processes which AR regulated in the LNCaP cells were enriched, including xenobiotic metabolic process, positive regulation of interleukin-2 production and cellular response to sterol etc. We finally identified 99 transcription factors with high motif enrichment significant levels, and the enrichment of AR co-located transcription factors was significantly enriched in the biological process of regulation of cell proliferation in which 13 transcription factors were involved (FOXJ1, FOXM1, NF1, SOX2, HOXD13, FOXO1, FOXP3, FOXO4, SOX9, PGR, DBP, JUN and TLX1). The analysis of AR target genes and gene functions help us to elucidate the mechanism of the prostate cancer on a molecular level. In addition, it will pave the way to effective therapies for prostatic cancer. However, further experiments are still needed to confirm our results." @default.
- W1805450185 created "2016-06-24" @default.
- W1805450185 creator A5025075819 @default.
- W1805450185 creator A5073212256 @default.
- W1805450185 creator A5075194907 @default.
- W1805450185 date "2015-08-18" @default.
- W1805450185 modified "2023-10-14" @default.
- W1805450185 title "Retraction Note to: ChIP-seq analysis of androgen receptor in LNCaP cell line" @default.
- W1805450185 doi "https://doi.org/10.1007/s11033-015-3903-9" @default.
- W1805450185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26285940" @default.
- W1805450185 hasPublicationYear "2015" @default.
- W1805450185 type Work @default.
- W1805450185 sameAs 1805450185 @default.
- W1805450185 citedByCount "1" @default.
- W1805450185 countsByYear W18054501852020 @default.
- W1805450185 crossrefType "journal-article" @default.
- W1805450185 hasAuthorship W1805450185A5025075819 @default.
- W1805450185 hasAuthorship W1805450185A5073212256 @default.
- W1805450185 hasAuthorship W1805450185A5075194907 @default.
- W1805450185 hasBestOaLocation W18054501851 @default.
- W1805450185 hasConcept C121608353 @default.
- W1805450185 hasConcept C185592680 @default.
- W1805450185 hasConcept C198352243 @default.
- W1805450185 hasConcept C2524010 @default.
- W1805450185 hasConcept C2779723316 @default.
- W1805450185 hasConcept C2780192828 @default.
- W1805450185 hasConcept C33923547 @default.
- W1805450185 hasConcept C41008148 @default.
- W1805450185 hasConcept C502942594 @default.
- W1805450185 hasConcept C54355233 @default.
- W1805450185 hasConcept C61367390 @default.
- W1805450185 hasConcept C70721500 @default.
- W1805450185 hasConcept C86803240 @default.
- W1805450185 hasConceptScore W1805450185C121608353 @default.
- W1805450185 hasConceptScore W1805450185C185592680 @default.
- W1805450185 hasConceptScore W1805450185C198352243 @default.
- W1805450185 hasConceptScore W1805450185C2524010 @default.
- W1805450185 hasConceptScore W1805450185C2779723316 @default.
- W1805450185 hasConceptScore W1805450185C2780192828 @default.
- W1805450185 hasConceptScore W1805450185C33923547 @default.
- W1805450185 hasConceptScore W1805450185C41008148 @default.
- W1805450185 hasConceptScore W1805450185C502942594 @default.
- W1805450185 hasConceptScore W1805450185C54355233 @default.
- W1805450185 hasConceptScore W1805450185C61367390 @default.
- W1805450185 hasConceptScore W1805450185C70721500 @default.
- W1805450185 hasConceptScore W1805450185C86803240 @default.
- W1805450185 hasIssue "10" @default.
- W1805450185 hasLocation W18054501851 @default.
- W1805450185 hasLocation W18054501852 @default.
- W1805450185 hasOpenAccess W1805450185 @default.
- W1805450185 hasPrimaryLocation W18054501851 @default.
- W1805450185 hasRelatedWork W1499838281 @default.
- W1805450185 hasRelatedWork W1527439723 @default.
- W1805450185 hasRelatedWork W2015889618 @default.
- W1805450185 hasRelatedWork W2023339104 @default.
- W1805450185 hasRelatedWork W2026190214 @default.
- W1805450185 hasRelatedWork W2037493716 @default.
- W1805450185 hasRelatedWork W2082788526 @default.
- W1805450185 hasRelatedWork W2166078539 @default.
- W1805450185 hasRelatedWork W2772229485 @default.
- W1805450185 hasRelatedWork W2806156214 @default.
- W1805450185 hasVolume "42" @default.
- W1805450185 isParatext "false" @default.
- W1805450185 isRetracted "false" @default.
- W1805450185 magId "1805450185" @default.
- W1805450185 workType "article" @default.