Matches in SemOpenAlex for { <https://semopenalex.org/work/W1805462004> ?p ?o ?g. }
- W1805462004 endingPage "1084" @default.
- W1805462004 startingPage "1075" @default.
- W1805462004 abstract "Medulloblastoma is the most common malignant brain tumour diagnosed in children. Over the last few decades, advances in radiation and chemotherapy have significantly improved the odds of survival. Nevertheless, one third of all patients still succumb to their disease, and many long-term survivors are afflicted with neurocognitive sequelae. Large-scale multi-institutional efforts have provided insight into the transcriptional and genetic landscape of medulloblastoma. Four distinct subgroups of medulloblastoma have been identified, defined by distinct transcriptomes, genetics, demographics and outcomes. Integrated genomic profiling of each of these subgroups has revealed distinct genetic alterations, driving pathways and in some instances cells of origin. In this review, we highlight, in a subgroup-specific manner, our current knowledge of the genetic and molecular alterations in medulloblastoma and underscore the possible avenues for future therapeutic intervention." @default.
- W1805462004 created "2016-06-24" @default.
- W1805462004 creator A5004065375 @default.
- W1805462004 creator A5022310517 @default.
- W1805462004 creator A5047816589 @default.
- W1805462004 date "2015-09-09" @default.
- W1805462004 modified "2023-10-18" @default.
- W1805462004 title "Genetic and molecular alterations across medulloblastoma subgroups" @default.
- W1805462004 cites W1572433661 @default.
- W1805462004 cites W1969665013 @default.
- W1805462004 cites W1971412744 @default.
- W1805462004 cites W1974625077 @default.
- W1805462004 cites W1974798136 @default.
- W1805462004 cites W1977572305 @default.
- W1805462004 cites W1979855662 @default.
- W1805462004 cites W1982852502 @default.
- W1805462004 cites W1983341583 @default.
- W1805462004 cites W1996409634 @default.
- W1805462004 cites W2003090246 @default.
- W1805462004 cites W2004380688 @default.
- W1805462004 cites W2004456850 @default.
- W1805462004 cites W2011334551 @default.
- W1805462004 cites W2017308570 @default.
- W1805462004 cites W2019231810 @default.
- W1805462004 cites W2022148326 @default.
- W1805462004 cites W2022266045 @default.
- W1805462004 cites W2024919859 @default.
- W1805462004 cites W2026234244 @default.
- W1805462004 cites W2030209169 @default.
- W1805462004 cites W2034882046 @default.
- W1805462004 cites W2039379153 @default.
- W1805462004 cites W2046285899 @default.
- W1805462004 cites W2046603817 @default.
- W1805462004 cites W2047966004 @default.
- W1805462004 cites W2057029910 @default.
- W1805462004 cites W2065169211 @default.
- W1805462004 cites W2066672792 @default.
- W1805462004 cites W2074099687 @default.
- W1805462004 cites W2076910437 @default.
- W1805462004 cites W2082080058 @default.
- W1805462004 cites W2084667421 @default.
- W1805462004 cites W2094252236 @default.
- W1805462004 cites W2094619972 @default.
- W1805462004 cites W2097316339 @default.
- W1805462004 cites W2097521277 @default.
- W1805462004 cites W2099920119 @default.
- W1805462004 cites W2101913110 @default.
- W1805462004 cites W2103694596 @default.
- W1805462004 cites W2104500293 @default.
- W1805462004 cites W2106039705 @default.
- W1805462004 cites W2108862374 @default.
- W1805462004 cites W2109214564 @default.
- W1805462004 cites W2109378990 @default.
- W1805462004 cites W2111130338 @default.
- W1805462004 cites W2114308127 @default.
- W1805462004 cites W2116532772 @default.
- W1805462004 cites W2117328669 @default.
- W1805462004 cites W2117559539 @default.
- W1805462004 cites W2118124054 @default.
- W1805462004 cites W2120173083 @default.
- W1805462004 cites W2121017846 @default.
- W1805462004 cites W2123035617 @default.
- W1805462004 cites W2125813110 @default.
- W1805462004 cites W2126738508 @default.
- W1805462004 cites W2127643721 @default.
- W1805462004 cites W2129331946 @default.
- W1805462004 cites W2129730239 @default.
- W1805462004 cites W2131008756 @default.
- W1805462004 cites W2133271442 @default.
- W1805462004 cites W2137804322 @default.
- W1805462004 cites W2138746991 @default.
- W1805462004 cites W2139499843 @default.
- W1805462004 cites W2139787372 @default.
- W1805462004 cites W2140213125 @default.
- W1805462004 cites W2148842308 @default.
- W1805462004 cites W2149657074 @default.
- W1805462004 cites W2150548551 @default.
- W1805462004 cites W2150794759 @default.
- W1805462004 cites W2153398041 @default.
- W1805462004 cites W2154951934 @default.
- W1805462004 cites W2157636873 @default.
- W1805462004 cites W2161535481 @default.
- W1805462004 cites W2162080206 @default.
- W1805462004 cites W2163732711 @default.
- W1805462004 cites W2163848072 @default.
- W1805462004 cites W2164671967 @default.
- W1805462004 cites W2167532631 @default.
- W1805462004 cites W2170552969 @default.
- W1805462004 cites W2171473481 @default.
- W1805462004 cites W2211600756 @default.
- W1805462004 cites W2320983896 @default.
- W1805462004 cites W4250627081 @default.
- W1805462004 doi "https://doi.org/10.1007/s00109-015-1333-8" @default.
- W1805462004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4599700" @default.
- W1805462004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26350064" @default.
- W1805462004 hasPublicationYear "2015" @default.
- W1805462004 type Work @default.
- W1805462004 sameAs 1805462004 @default.