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- W18054718 abstract "Objective:To investigate the genetic characterization(evolution,antigenicity,enzymatically active site,and glycosylation site)of the neuraminidase(NA)gene of the novel influenza virus A/H1N1 in 2009 pandemic.Methods:Genetic evolution and amino acid substitutions of the 43 NA gene sequences of influenza virus A of different years were retrieved from GenBank and were analyzed by using MEGA 4.0 software.Results:The new A/H1N1 influenza virus strains and avian H5N1 influenza virus strains had similar antigen sites of the NA genes,sharing a homology of 85%.Amino acid residues at the enzymatically active site of the NA genes were strictly conserved in all influenza virus strains,but the glycosylation sites varied.Conclusion:The NA genes of novel H1N1 influenza viruses may originate from avian H5N1 influenza virus endemic in Asia.The new H1N1 influenza viruses may respond well to the neuraminidase inhibitor treatment." @default.
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- W18054718 date "2009-01-01" @default.
- W18054718 modified "2023-09-22" @default.
- W18054718 title "Genetic characterization of neuraminidase gene of novel influenza virus A/H1N1 in 2009 pandemic." @default.
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