FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1805590927> ?p ?o ?g. }

• W1805590927 endingPage "751" @default.
• W1805590927 startingPage "742" @default.
• W1805590927 abstract "The outer membrane protein A il of Y ersinia pestis mediates several virulence functions, including serum resistance. Here, we demonstrate that A il binds C 4b‐binding protein ( C 4 BP ), the primary fluid‐phase regulator of the classical and lectin pathways. Non‐covalent binding of C 4 and C 4b to A il was also observed. C 4 BP bound to A il can act as a cofactor to the serine protease factor I (fI) in the cleavage of fluid‐phase C 4b. Employing a panel of C 4 BP alpha‐chain mutants, we observed that the absence of complement control protein domain 6 and 8 reduced binding to Ail. Immunoblot analysis of normal human serum ( NHS )‐treated bacteria revealed minimal C 4b alpha’‐chain complexes with bacterial outer membrane targets. Addition of the anti‐ C 4 BP monoclonal antibody MK 104 to NHS restored C 4b‐alpha’ chain target complexes, suggesting that C 4b binds covalently to targets on the Y. pestis surface. C4b bound to A il noncovalently was also cleaved in a C 4 BP and fI‐dependent manner, leaving the C 4c fragment bound to A il. MK 104 also prevented the cleavage of noncovalently bound C 4b. Collectively, these data suggest that when C 4 BP is bound to A il, fI can cleave and inactivate C 4b that has bound covalently to bacterial surface structures as well as C 4b bound noncovalently to A il." @default.
• W1805590927 created "2016-06-24" @default.
• W1805590927 creator A5025820462 @default.
• W1805590927 creator A5060352582 @default.
• W1805590927 creator A5068835834 @default.
• W1805590927 creator A5088252343 @default.
• W1805590927 date "2014-01-13" @default.
• W1805590927 modified "2023-10-16" @default.
• W1805590927 title "<i>Yersinia pestis</i>Ail recruitment of C4b-binding protein leads to factor I-mediated inactivation of covalently and noncovalently bound C4b" @default.
• W1805590927 cites W1812041024 @default.
• W1805590927 cites W1870972790 @default.
• W1805590927 cites W2016954174 @default.
• W1805590927 cites W2031895664 @default.
• W1805590927 cites W2047718759 @default.
• W1805590927 cites W2048215714 @default.
• W1805590927 cites W2048269077 @default.
• W1805590927 cites W2056425532 @default.
• W1805590927 cites W2062999231 @default.
• W1805590927 cites W2066143759 @default.
• W1805590927 cites W2068991108 @default.
• W1805590927 cites W2070225439 @default.
• W1805590927 cites W2076353777 @default.
• W1805590927 cites W2090984178 @default.
• W1805590927 cites W2094534201 @default.
• W1805590927 cites W2105005583 @default.
• W1805590927 cites W2118932941 @default.
• W1805590927 cites W2126186605 @default.
• W1805590927 cites W2127308341 @default.
• W1805590927 cites W2127650323 @default.
• W1805590927 cites W2131558932 @default.
• W1805590927 cites W2131846924 @default.
• W1805590927 cites W2144289082 @default.
• W1805590927 cites W2145638464 @default.
• W1805590927 cites W2150512732 @default.
• W1805590927 cites W2152591548 @default.
• W1805590927 cites W2154910306 @default.
• W1805590927 cites W2163949252 @default.
• W1805590927 cites W2164383866 @default.
• W1805590927 cites W2316650677 @default.
• W1805590927 cites W315197452 @default.
• W1805590927 doi "https://doi.org/10.1002/eji.201343552" @default.
• W1805590927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24765656" @default.
• W1805590927 hasPublicationYear "2014" @default.
• W1805590927 type Work @default.
• W1805590927 sameAs 1805590927 @default.
• W1805590927 citedByCount "25" @default.
• W1805590927 countsByYear W18055909272014 @default.
• W1805590927 countsByYear W18055909272015 @default.
• W1805590927 countsByYear W18055909272016 @default.
• W1805590927 countsByYear W18055909272017 @default.
• W1805590927 countsByYear W18055909272018 @default.
• W1805590927 countsByYear W18055909272019 @default.
• W1805590927 countsByYear W18055909272020 @default.
• W1805590927 countsByYear W18055909272021 @default.
• W1805590927 countsByYear W18055909272022 @default.
• W1805590927 countsByYear W18055909272023 @default.
• W1805590927 crossrefType "journal-article" @default.
• W1805590927 hasAuthorship W1805590927A5025820462 @default.
• W1805590927 hasAuthorship W1805590927A5060352582 @default.
• W1805590927 hasAuthorship W1805590927A5068835834 @default.
• W1805590927 hasAuthorship W1805590927A5088252343 @default.
• W1805590927 hasBestOaLocation W18055909271 @default.
• W1805590927 hasConcept C104317684 @default.
• W1805590927 hasConcept C107824862 @default.
• W1805590927 hasConcept C151730666 @default.
• W1805590927 hasConcept C153911025 @default.
• W1805590927 hasConcept C175156509 @default.
• W1805590927 hasConcept C178790620 @default.
• W1805590927 hasConcept C180577832 @default.
• W1805590927 hasConcept C181199279 @default.
• W1805590927 hasConcept C185592680 @default.
• W1805590927 hasConcept C2776714187 @default.
• W1805590927 hasConcept C2777807008 @default.
• W1805590927 hasConcept C2778222588 @default.
• W1805590927 hasConcept C2781090273 @default.
• W1805590927 hasConcept C43369102 @default.
• W1805590927 hasConcept C51639874 @default.
• W1805590927 hasConcept C55493867 @default.
• W1805590927 hasConcept C60987743 @default.
• W1805590927 hasConcept C86803240 @default.
• W1805590927 hasConceptScore W1805590927C104317684 @default.
• W1805590927 hasConceptScore W1805590927C107824862 @default.
• W1805590927 hasConceptScore W1805590927C151730666 @default.
• W1805590927 hasConceptScore W1805590927C153911025 @default.
• W1805590927 hasConceptScore W1805590927C175156509 @default.
• W1805590927 hasConceptScore W1805590927C178790620 @default.
• W1805590927 hasConceptScore W1805590927C180577832 @default.
• W1805590927 hasConceptScore W1805590927C181199279 @default.
• W1805590927 hasConceptScore W1805590927C185592680 @default.
• W1805590927 hasConceptScore W1805590927C2776714187 @default.
• W1805590927 hasConceptScore W1805590927C2777807008 @default.
• W1805590927 hasConceptScore W1805590927C2778222588 @default.
• W1805590927 hasConceptScore W1805590927C2781090273 @default.
• W1805590927 hasConceptScore W1805590927C43369102 @default.
• W1805590927 hasConceptScore W1805590927C51639874 @default.
• W1805590927 hasConceptScore W1805590927C55493867 @default.
• W1805590927 hasConceptScore W1805590927C60987743 @default.
• W1805590927 hasConceptScore W1805590927C86803240 @default.

• next