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- W1805637547 abstract "In treatment of motion affected tumours by means of a scanned particle beam severe under andover dosage can occur due to the interplay effect. By using gated beam delivery effective targetmotion is reduced, but even for the residual motion the interplay effect can lead to unsatisfactorydose distributions. Furthermore, an appropriate motion monitoring system is essential sincebeam delivery has to be synchronized to target motion.In this work three aspects were investigated to move gating closer towards clinical operationat Heidelberg Ion-Beam Therapy Center (HIT): Firstly, influences of beam parameters ondosimetric effects of residual motion were investigated in experiments and simulations. Increasedfocus sizes and reduced iso-energy distances turned out to be an effective methodto gain dose homogeneity whereas reduction of lateral beam position spacing did not showsuch an effect. Secondly, to enable systematic studies of mitigation techniques and effects ofmiscorrelation between motion monitoring system and tumour motion a phantom with 6D targetand independent thorax motion was constructed and validated successfully in experiments.Thirdly, two motion monitoring systems by VisionRT Ltd. and Anzai Medical Co.,Ltd., respectively,were compared in terms of gating delays and correlation to tumour motion extractedfrom MV-fluoroscopy. While the VisionRT system showed larger delays than the Anzai systemunder laboratory conditions, no significant difference between the systems with respect totumour-correlation was found in a clinical study.Results of this work will be incorporated into patient treatments using gating that will start atHIT within the next few months. Furthermore, a phantom simulating thorax and target motionwith a variety of applications such as 4D imaging is now available and already in use by severalgroups." @default.
- W1805637547 created "2016-06-24" @default.
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- W1805637547 date "2011-12-21" @default.
- W1805637547 modified "2023-09-27" @default.
- W1805637547 title "Gating for scanned ion beam therapy" @default.
- W1805637547 hasPublicationYear "2011" @default.
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