FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1806183733> ?p ?o ?g. }

• W1806183733 endingPage "124" @default.
• W1806183733 startingPage "115" @default.
• W1806183733 abstract "Trichomonas vaginalis is a parasite that resides in the human urogenital tract and causes trichomonosis, the most prevalent nonviral sexually transmitted disease. Nucleoside triphosphate diphosphohydrolase (NTPDase), which hydrolyzes extracellular di- and triphosphate nucleotides, and ecto-5'-nucleotidase, which hydrolyzes AMP, have been characterized in T. vaginalis. The aim of this study was to characterize the adenosine deaminase (ADA) activity in intact trophozoites of T. vaginalis. A strong inhibition in adenosine deamination was observed in the presence of calcium and magnesium, which was prevented by EDTA. The apparent K(M) value for adenosine was 1.13 ± 0.07mM. The calculated V(max) was 2.61 ± 0.054 nmol NH(3) min(-1) mg(-1) protein. Adenosine deamination was inhibited in the presence of erythro-9-(2-hydroxy-3-nonyl)adenine. Semi-quantitative reverse transcriptase-PCR experiments were performed and both ADA-related genes ada(125) and ada(231) mRNA were expressed, although ada(231) in higher quantity when compared with the ada(125) : α-tubulin ratio. Furthermore, a phylogenetic analysis showed that the T. vaginalis sequences formed a clade with Entamoeba histolytica and Dictyostelium discoideum sequences, and it strongly suggests homologous functions in the T. vaginalis genome. The presence of ADA activity in T. vaginalis may be important to modulate the adenosine/inosine levels during infection and, consequently, to maintain the anti-inflammatory properties through different nucleoside-signalling mechanisms." @default.
• W1806183733 created "2016-06-24" @default.
• W1806183733 creator A5008213735 @default.
• W1806183733 creator A5020559776 @default.
• W1806183733 creator A5027412822 @default.
• W1806183733 creator A5045346402 @default.
• W1806183733 creator A5045594984 @default.
• W1806183733 creator A5055910162 @default.
• W1806183733 creator A5056251882 @default.
• W1806183733 creator A5068680303 @default.
• W1806183733 creator A5084389495 @default.
• W1806183733 date "2011-04-26" @default.
• W1806183733 modified "2023-09-25" @default.
• W1806183733 title "Kinetic characterization and gene expression of adenosine deaminase in intact trophozoites of Trichomonas vaginalis" @default.
• W1806183733 cites W1526101793 @default.
• W1806183733 cites W1542295790 @default.
• W1806183733 cites W1912877847 @default.
• W1806183733 cites W1982230576 @default.
• W1806183733 cites W1984474879 @default.
• W1806183733 cites W1986830036 @default.
• W1806183733 cites W1999033072 @default.
• W1806183733 cites W2000041261 @default.
• W1806183733 cites W2000714729 @default.
• W1806183733 cites W2008451240 @default.
• W1806183733 cites W2011584599 @default.
• W1806183733 cites W2014734144 @default.
• W1806183733 cites W2015166171 @default.
• W1806183733 cites W2021614849 @default.
• W1806183733 cites W2023146545 @default.
• W1806183733 cites W2023237612 @default.
• W1806183733 cites W2023829459 @default.
• W1806183733 cites W2025656644 @default.
• W1806183733 cites W2042906495 @default.
• W1806183733 cites W2047478018 @default.
• W1806183733 cites W2057299068 @default.
• W1806183733 cites W2065861032 @default.
• W1806183733 cites W2068356439 @default.
• W1806183733 cites W2070800058 @default.
• W1806183733 cites W2081444033 @default.
• W1806183733 cites W2097817484 @default.
• W1806183733 cites W2108186280 @default.
• W1806183733 cites W2115863321 @default.
• W1806183733 cites W2121484720 @default.
• W1806183733 cites W2123523712 @default.
• W1806183733 cites W2133580420 @default.
• W1806183733 cites W2135297713 @default.
• W1806183733 cites W2137142721 @default.
• W1806183733 cites W2148537294 @default.
• W1806183733 cites W2162525617 @default.
• W1806183733 cites W2254834000 @default.
• W1806183733 cites W4236928373 @default.
• W1806183733 cites W4293247451 @default.
• W1806183733 doi "https://doi.org/10.1111/j.1574-6968.2011.02283.x" @default.
• W1806183733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21477257" @default.
• W1806183733 hasPublicationYear "2011" @default.
• W1806183733 type Work @default.
• W1806183733 sameAs 1806183733 @default.
• W1806183733 citedByCount "7" @default.
• W1806183733 countsByYear W18061837332015 @default.
• W1806183733 countsByYear W18061837332016 @default.
• W1806183733 countsByYear W18061837332017 @default.
• W1806183733 countsByYear W18061837332021 @default.
• W1806183733 crossrefType "journal-article" @default.
• W1806183733 hasAuthorship W1806183733A5008213735 @default.
• W1806183733 hasAuthorship W1806183733A5020559776 @default.
• W1806183733 hasAuthorship W1806183733A5027412822 @default.
• W1806183733 hasAuthorship W1806183733A5045346402 @default.
• W1806183733 hasAuthorship W1806183733A5045594984 @default.
• W1806183733 hasAuthorship W1806183733A5055910162 @default.
• W1806183733 hasAuthorship W1806183733A5056251882 @default.
• W1806183733 hasAuthorship W1806183733A5068680303 @default.
• W1806183733 hasAuthorship W1806183733A5084389495 @default.
• W1806183733 hasBestOaLocation W18061837332 @default.
• W1806183733 hasConcept C104317684 @default.
• W1806183733 hasConcept C145782189 @default.
• W1806183733 hasConcept C153911025 @default.
• W1806183733 hasConcept C181199279 @default.
• W1806183733 hasConcept C18880352 @default.
• W1806183733 hasConcept C2775969001 @default.
• W1806183733 hasConcept C2776352584 @default.
• W1806183733 hasConcept C2776543447 @default.
• W1806183733 hasConcept C2776867272 @default.
• W1806183733 hasConcept C2776991684 @default.
• W1806183733 hasConcept C2781114625 @default.
• W1806183733 hasConcept C34628245 @default.
• W1806183733 hasConcept C512185932 @default.
• W1806183733 hasConcept C55493867 @default.
• W1806183733 hasConcept C86803240 @default.
• W1806183733 hasConcept C89423630 @default.
• W1806183733 hasConceptScore W1806183733C104317684 @default.
• W1806183733 hasConceptScore W1806183733C145782189 @default.
• W1806183733 hasConceptScore W1806183733C153911025 @default.
• W1806183733 hasConceptScore W1806183733C181199279 @default.
• W1806183733 hasConceptScore W1806183733C18880352 @default.
• W1806183733 hasConceptScore W1806183733C2775969001 @default.
• W1806183733 hasConceptScore W1806183733C2776352584 @default.
• W1806183733 hasConceptScore W1806183733C2776543447 @default.
• W1806183733 hasConceptScore W1806183733C2776867272 @default.

• next