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• W1806357672 endingPage "937" @default.
• W1806357672 startingPage "929" @default.
• W1806357672 abstract "A monoclonal antibody, EGR/ G49 , raised against the receptor for epidermal growth factor (EGF) present in A431 cells inhibits EGF binding by decreasing the affinity of the major population of low affinity receptors while leaving the minor high affinity population relatively unperturbed. The antibody, which binds to a carbohydrate determinant at a site distinct from the EGF binding site, induces clustering and internalisation of the receptor without stimulating the EGF receptor-kinase or affecting its ability to undergo stimulation by EGF. It is toxic to A431 cells and induces morphological changes similar to those seen when these cells are challenged with EGF in the concentration range 1-10 nM. These results suggest that high and low affinity EGF receptors can be distinguished and that they may serve different functions." @default.
• W1806357672 created "2016-06-24" @default.
• W1806357672 creator A5004929409 @default.
• W1806357672 creator A5084399713 @default.
• W1806357672 date "1984-05-01" @default.
• W1806357672 modified "2023-09-26" @default.
• W1806357672 title "Properties of a monoclonal antibody to epidermal growth factor receptor with implications for the mechanism of action of EGF." @default.
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• W1806357672 doi "https://doi.org/10.1002/j.1460-2075.1984.tb01910.x" @default.
• W1806357672 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/557454" @default.
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• W1806357672 hasPublicationYear "1984" @default.
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