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• W1806370607 startingPage "122" @default.
• W1806370607 abstract "17β-Oestradiol (E(2)) is essential for cyclical gonadotrophin-releasing hormone (GnRH) neuronal activity and secretion. In particular, E(2) increases the excitability of GnRH neurones during the afternoon of pro-oestrus in the rodent, which is associated with increased synthesis and secretion of GnRH. It is well established that E(2) regulates the activity of GnRH neurones through both presynaptic and postsynaptic mechanisms. E(2) significantly modulates the mRNA expression of numerous ion channels in GnRH neurones and alters the associated endogenous conductances, including potassium (K(ATP) , A-type) currents and low-voltage T-type and high-voltage L-type calcium currents. Notably, K(ATP) channels are critical for maintaining GnRH neurones in a hyperpolarised state for recruiting the T-type calcium channels, which are important for burst firing in GnRH neurones. In addition, there are other critical channels contributing to burst firing pattern, including the small conductance Ca(2+) -activated K(+) channels that may be modulated by E(2) . Despite these advances, the cellular mechanisms underlying the cyclical GnRH neuronal activity and GnRH release are largely unknown. Ultimately, the ensemble of both pre- and postsynaptic targets of the actions of E(2) will dictate the excitability and activity pattern of GnRH neurones." @default.
• W1806370607 created "2016-06-24" @default.
• W1806370607 creator A5035033862 @default.
• W1806370607 creator A5076334785 @default.
• W1806370607 creator A5077777334 @default.
• W1806370607 date "2011-12-20" @default.
• W1806370607 modified "2023-10-18" @default.
• W1806370607 title "17β-Oestradiol Regulation of Gonadotrophin-Releasing Hormone Neuronal Excitability" @default.
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• W1806370607 doi "https://doi.org/10.1111/j.1365-2826.2011.02160.x" @default.
• W1806370607 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3572201" @default.
• W1806370607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21592235" @default.
• W1806370607 hasPublicationYear "2011" @default.

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