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• W180656536 abstract "Over the last couple of decades of neuro-immunological research, the p40 family of cytokines has emerged out as one of the most intriguing areas of interest because of multi-faceted roles of these cytokine in immune-modulation and inflammation. The IL-12, the most widely studied cytokine of this family, is well-characterized for its Th1-favoring activity, and therefore plays a key role in the pathophysiology of Th1-mediated autoimmune diseases like multiple sclerosis (MS). On the other hand, the IL-23, another member of the p40 family with shared p40 subunit, drives polarization of Th17, a subset of T cell suspected to have a key role in the pathophysiology of MS and experimental allergic encephalomyelitis (EAE), poses a challenge to our current understanding of Th1/Th2 hypotheses in autoimmune diseases. However, the more puzzling issues, the researchers are currently confronted with, are the biological roles of other two members of this family, the p40 monomer and the p40(2), the homodimer. Predominance of the mRNA level of p40 over p35 in the central nervous system of EAE and MS suggests a possible involvement of p40 in the pathogenesis of MS. However, the distinctive biological role of monomeric and dimeric form of p40 is not clearly understood yet. Initially, it was thought that p402 does not have any biological activity and only involved in antagonizing bioactive IL-12 but according to recent evidences, both p402 and p40 appear to have a proinflammatory role, therefore might be a crucial molecule in the pathogenesis of MS. The current review focuses on biological function of p40 family of cytokines with particular emphasis on MS." @default.
• W180656536 created "2016-06-24" @default.
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• W180656536 date "2008-04-01" @default.
• W180656536 modified "2023-09-23" @default.
• W180656536 title "Role of cytokine p40 family in multiple sclerosis." @default.
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• W180656536 cites W1562632940 @default.
• W180656536 cites W1609474951 @default.
• W180656536 cites W1678871737 @default.
• W180656536 cites W1847326477 @default.
• W180656536 cites W1867019379 @default.
• W180656536 cites W1920166506 @default.
• W180656536 cites W1945946018 @default.
• W180656536 cites W1950477528 @default.
• W180656536 cites W1966419386 @default.
• W180656536 cites W1968918322 @default.
• W180656536 cites W1971213127 @default.
• W180656536 cites W1974771163 @default.
• W180656536 cites W1986217339 @default.
• W180656536 cites W1987641831 @default.
• W180656536 cites W1989520579 @default.
• W180656536 cites W1991524518 @default.
• W180656536 cites W2004143904 @default.
• W180656536 cites W2005945501 @default.
• W180656536 cites W2006249161 @default.
• W180656536 cites W2009219530 @default.
• W180656536 cites W2015479125 @default.
• W180656536 cites W2017820296 @default.
• W180656536 cites W2029025255 @default.
• W180656536 cites W2029894447 @default.
• W180656536 cites W2030411429 @default.
• W180656536 cites W2034778776 @default.
• W180656536 cites W2036839645 @default.
• W180656536 cites W2037043234 @default.
• W180656536 cites W2041508820 @default.
• W180656536 cites W2046932107 @default.
• W180656536 cites W2048131048 @default.
• W180656536 cites W2048684002 @default.
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• W180656536 cites W2079982783 @default.
• W180656536 cites W2080749904 @default.
• W180656536 cites W2084726943 @default.
• W180656536 cites W2087905758 @default.
• W180656536 cites W2088590507 @default.
• W180656536 cites W2090197666 @default.
• W180656536 cites W2095386502 @default.
• W180656536 cites W2100286113 @default.
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• W180656536 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2570259" @default.
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