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• W1806950858 abstract "Apolipoprotein E4 (apoE4) is the most prevalent genetic risk factor for Alzheimer's disease (AD). Epidemiological studies revealed that consumption of docosahexaenoic acid (DHA: 22 : 6 (ω3)), a major brain polyunsaturated fatty acid, is protective for AD and that elevated cholesterol levels are an AD risk factor. We presently investigated the extent to which the pathological effects of apoE4 in vivo can be prevented by consuming fish oil (DHA) or can be modified by cholesterol. Accordingly, apoE3- and apoE4-targeted replacement mice were subjected, following weaning, to a fish oil diet enriched in DHA and to a cholesterol-containing diet under regular and enriched environments. Cholesterol metabolism in the hippocampus and the corresponding phospholipid and fatty acid levels were affected by fish oil (DHA) and cholesterol diets and by environmental stimulation. Importantly, cholesterol metabolism and the fatty acid levels were not affected by apoE4. The phospholipid levels were, however, affected by apoE4. This effect was most pronounced in the cholesterol-fed mice and was abolished by the fish oil (DHA) diet. ApoE4 elevated hippocampal intraneuronal amyloid-β levels under regular conditions and lowered them following environmental stimulation, relative to those of the apoE3 mice. ApoE4 also elevated the levels of the presynaptic transporters Vglut and Vgat, and decreased behavioral performance in an object recognition test. Importantly, all of these apoE4 phenotypes were abolished by the fish oil (DHA) diet, whereas the cholesterol diet modified them. These findings suggest that a fish oil (DHA) diet could be used to attenuate the effects of apoE4 in AD." @default.
• W1806950858 created "2016-06-24" @default.
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• W1806950858 date "2012-02-07" @default.
• W1806950858 modified "2023-10-18" @default.
• W1806950858 title "The Isoform-Specific Pathological Effects of ApoE4 in vivo are Prevented by a Fish Oil (DHA) Diet and are Modified by Cholesterol" @default.
• W1806950858 cites W1480505629 @default.
• W1806950858 cites W1540054269 @default.
• W1806950858 cites W1602494991 @default.
• W1806950858 cites W1965643342 @default.
• W1806950858 cites W1968260559 @default.
• W1806950858 cites W1971310777 @default.
• W1806950858 cites W1971684738 @default.
• W1806950858 cites W1972485653 @default.
• W1806950858 cites W1974878596 @default.
• W1806950858 cites W1975478041 @default.
• W1806950858 cites W1983245960 @default.
• W1806950858 cites W1983829653 @default.
• W1806950858 cites W1987099311 @default.
• W1806950858 cites W1989546154 @default.
• W1806950858 cites W1991366780 @default.
• W1806950858 cites W1993121285 @default.
• W1806950858 cites W1998427310 @default.
• W1806950858 cites W1999631936 @default.
• W1806950858 cites W2001688761 @default.
• W1806950858 cites W2003742510 @default.
• W1806950858 cites W2005390270 @default.
• W1806950858 cites W2006409771 @default.
• W1806950858 cites W2011885704 @default.
• W1806950858 cites W2012568539 @default.
• W1806950858 cites W2017595192 @default.
• W1806950858 cites W2021148483 @default.
• W1806950858 cites W2025871534 @default.
• W1806950858 cites W2031729539 @default.
• W1806950858 cites W2032452147 @default.
• W1806950858 cites W2032783489 @default.
• W1806950858 cites W2036362108 @default.
• W1806950858 cites W2041325253 @default.
• W1806950858 cites W2041895791 @default.
• W1806950858 cites W2042130020 @default.
• W1806950858 cites W2042421739 @default.
• W1806950858 cites W2042677967 @default.
• W1806950858 cites W2043141442 @default.
• W1806950858 cites W2046952010 @default.
• W1806950858 cites W2047397116 @default.
• W1806950858 cites W2053584231 @default.
• W1806950858 cites W2061632909 @default.
• W1806950858 cites W2066673859 @default.
• W1806950858 cites W2067064610 @default.
• W1806950858 cites W2068414557 @default.
• W1806950858 cites W2069638209 @default.
• W1806950858 cites W2072303213 @default.
• W1806950858 cites W2073620036 @default.
• W1806950858 cites W2074871965 @default.
• W1806950858 cites W2079183773 @default.
• W1806950858 cites W2085235587 @default.
• W1806950858 cites W2086572083 @default.
• W1806950858 cites W2087040730 @default.
• W1806950858 cites W2089100905 @default.
• W1806950858 cites W2094472277 @default.
• W1806950858 cites W2102005177 @default.
• W1806950858 cites W2106888831 @default.
• W1806950858 cites W2107094473 @default.
• W1806950858 cites W2112295687 @default.
• W1806950858 cites W2112957305 @default.
• W1806950858 cites W2118416292 @default.
• W1806950858 cites W2121101037 @default.
• W1806950858 cites W2121949268 @default.
• W1806950858 cites W2131422017 @default.
• W1806950858 cites W2133385892 @default.
• W1806950858 cites W2137903730 @default.
• W1806950858 cites W2138377603 @default.
• W1806950858 cites W2139747033 @default.
• W1806950858 cites W2143470402 @default.
• W1806950858 cites W2148809657 @default.
• W1806950858 cites W2148918646 @default.
• W1806950858 cites W2149944282 @default.
• W1806950858 cites W2151761943 @default.
• W1806950858 cites W2156998090 @default.
• W1806950858 cites W2158398390 @default.
• W1806950858 cites W2167376541 @default.
• W1806950858 cites W2169152986 @default.
• W1806950858 cites W2169359444 @default.
• W1806950858 cites W2170218376 @default.
• W1806950858 cites W2403716091 @default.
• W1806950858 cites W8746562 @default.
• W1806950858 cites W98152484 @default.
• W1806950858 doi "https://doi.org/10.3233/jad-2011-111265" @default.
• W1806950858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22057027" @default.
• W1806950858 hasPublicationYear "2012" @default.

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