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- W180731264 abstract "The hallmark of B-cell development is the ordered recombination of immunoglobulin (Ig) genes. Recently, considerable progress has been achieved in assembling gene regulatory networks comprised of signaling components and transcription factors that regulate B-cell development. In this chapter we synthesize experimental evidence to explain how such signaling pathways and transcription factors can orchestrate the ordered recombination of immunoglobulin (Ig) genes. Recombination of antigen-receptor loci is regulated both by the developmentally controlled expression of the Rag1 and Rag2 genes and the accessibility of particular loci and their gene segments to recombination. A new framework has emerged that invokes nuclear compartmentalization, large-scale chromatin dynamics and localized changes in chromatin structure in regulating the accessibility of Ig loci at specific stages of B-cell development. We review this emergent framework and discuss new experimental approaches that will be needed to explore the underlying molecular mechanisms." @default.
- W180731264 created "2016-06-24" @default.
- W180731264 creator A5013350539 @default.
- W180731264 creator A5013869141 @default.
- W180731264 creator A5087518703 @default.
- W180731264 date "2009-01-01" @default.
- W180731264 modified "2023-09-24" @default.
- W180731264 title "Molecular Pathways and Mechanisms Regulating the Recombination of Immunoglobulin Genes during B-Lymphocyte Development" @default.
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- W180731264 doi "https://doi.org/10.1007/978-1-4419-0296-2_11" @default.
- W180731264 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19731807" @default.
- W180731264 hasPublicationYear "2009" @default.
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