FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1807712971> ?p ?o ?g. }

• W1807712971 abstract "Herpes simplex virus type 1 (HSV)-specific CD8+ T cells provide immunosurveillance of trigeminal ganglion (TG) neurons that harbor latent HSV-1 and prevent viral reactivation. Recurrent reactivations of HSV-1 from latency in the TG can result in severe corneal immunopathology and progressive scarring, leading to a blinding disease called Herpetic Stromal Keratitis. Therefore it is of significant clinical relevance to develop immunotherapies that are designed to boost the immune responses that prevent or reduce the frequency of HSV-1 reactivations. Programmed Death-1 (PD-1) is an inhibitory receptor that is expressed on many types of activated immune cells and regulates their cytokine production and numbers, with high levels of PD-1 inducing apoptosis and low expression inhibiting proliferation. Our goal was to investigate the role of a PD-1 ligand, PD-L1/B7-H1, during HSV-1 infection, and test whether blocking PD-L1 will enhance the innate immune response that clears the initial viral infection, and the adaptive immune response that prevents reactivation from latency. We used a mouse model of HSV-1 infection in which virus infection of the corneal epithelium leads to formation of a lesion; and simultaneous transmission of the virus to the TG results in establishment of HSV-1 latency in a portion of TG neurons. We found that PD-L1 was expressed on HSV-1- infected corneal epithelial cells during acute HSV-1 infection and was preferentially up- regulated by IFN-γ on HSV-1-infected neurons during latency. Using B7-H1/PD-L1-/- mice during acute HSV-1 infection, we found that 1) PD-L1 expressed on corneal epithelium and bone marrow-derived CD45+ cells in the cornea inhibits efficient recruitment of Gr-1+ cells (monocytes/neutrophils) by suppressing chemokine production, 2) PD-L1 expressed on corneal epithelium inhibits γδ T cell infiltration into the infected cornea, and 3) PD-L1 promotes proper DC maturation during T cell priming in the draining lymph nodes. During latent HSV-1 infection, PD-L1 expressed on TG neurons inhibits the survival but not proliferation and cytokine production of TG-resident subdominant CD8+ T cells. B7-H1-/- mice had an enlarged population of PD-1high subdominant CD8+ T cells that did not provide enhanced protection from HSV-1 reactivation, suggesting that PD-L1 blockade may not be an attractive option as immunotherapy against HSK." @default.
• W1807712971 created "2016-06-24" @default.
• W1807712971 creator A5042613245 @default.
• W1807712971 date "2014-03-20" @default.
• W1807712971 modified "2023-09-26" @default.
• W1807712971 title "The role of programmed death ligand-1 (PD-L1/B7-H1) in regulating the immune responses against herpes simplex virus-1 (HSV-1)" @default.
• W1807712971 cites W137273575 @default.
• W1807712971 cites W1494043282 @default.
• W1807712971 cites W149690328 @default.
• W1807712971 cites W1511635744 @default.
• W1807712971 cites W1516454320 @default.
• W1807712971 cites W1518766399 @default.
• W1807712971 cites W1520207918 @default.
• W1807712971 cites W1522653250 @default.
• W1807712971 cites W1538902372 @default.
• W1807712971 cites W1584949915 @default.
• W1807712971 cites W1585192075 @default.
• W1807712971 cites W1597074274 @default.
• W1807712971 cites W1598900039 @default.
• W1807712971 cites W16680595 @default.
• W1807712971 cites W169105841 @default.
• W1807712971 cites W1699918302 @default.
• W1807712971 cites W1806240087 @default.
• W1807712971 cites W1880142700 @default.
• W1807712971 cites W1884861492 @default.
• W1807712971 cites W1904163195 @default.
• W1807712971 cites W1915210168 @default.
• W1807712971 cites W1925864442 @default.
• W1807712971 cites W1942267505 @default.
• W1807712971 cites W1943350189 @default.
• W1807712971 cites W1949498377 @default.
• W1807712971 cites W1963816826 @default.
• W1807712971 cites W1963871085 @default.
• W1807712971 cites W1965710385 @default.
• W1807712971 cites W1968321644 @default.
• W1807712971 cites W1968593829 @default.
• W1807712971 cites W1968643495 @default.
• W1807712971 cites W1969144061 @default.
• W1807712971 cites W1971985239 @default.
• W1807712971 cites W1972543205 @default.
• W1807712971 cites W1972882573 @default.
• W1807712971 cites W1973682675 @default.
• W1807712971 cites W1978436252 @default.
• W1807712971 cites W1980812273 @default.
• W1807712971 cites W1983831001 @default.
• W1807712971 cites W1986854935 @default.
• W1807712971 cites W1986868882 @default.
• W1807712971 cites W1986954791 @default.
• W1807712971 cites W1987337657 @default.
• W1807712971 cites W1993335251 @default.
• W1807712971 cites W1993617345 @default.
• W1807712971 cites W1995371324 @default.
• W1807712971 cites W1995712355 @default.
• W1807712971 cites W1995796039 @default.
• W1807712971 cites W1997001042 @default.
• W1807712971 cites W1997878709 @default.
• W1807712971 cites W1998998882 @default.
• W1807712971 cites W2000177786 @default.
• W1807712971 cites W2001284801 @default.
• W1807712971 cites W2001714916 @default.
• W1807712971 cites W2002197941 @default.
• W1807712971 cites W2003709053 @default.
• W1807712971 cites W2005220504 @default.
• W1807712971 cites W2006485530 @default.
• W1807712971 cites W2008221423 @default.
• W1807712971 cites W2011199583 @default.
• W1807712971 cites W2016773712 @default.
• W1807712971 cites W2016789384 @default.
• W1807712971 cites W2016909108 @default.
• W1807712971 cites W2016983859 @default.
• W1807712971 cites W2017410453 @default.
• W1807712971 cites W2020812449 @default.
• W1807712971 cites W2021377837 @default.
• W1807712971 cites W2022580424 @default.
• W1807712971 cites W2023268555 @default.
• W1807712971 cites W2024207873 @default.
• W1807712971 cites W2024438032 @default.
• W1807712971 cites W2028376975 @default.
• W1807712971 cites W2033193447 @default.
• W1807712971 cites W2035660473 @default.
• W1807712971 cites W2035852466 @default.
• W1807712971 cites W2036301707 @default.
• W1807712971 cites W2036348588 @default.
• W1807712971 cites W2038358420 @default.
• W1807712971 cites W2040793402 @default.
• W1807712971 cites W2040838085 @default.
• W1807712971 cites W2042364269 @default.
• W1807712971 cites W2044527664 @default.
• W1807712971 cites W2048916379 @default.
• W1807712971 cites W2054103621 @default.
• W1807712971 cites W2055666727 @default.
• W1807712971 cites W2056295530 @default.
• W1807712971 cites W2056330259 @default.
• W1807712971 cites W2056799177 @default.
• W1807712971 cites W2057453581 @default.
• W1807712971 cites W2057499380 @default.
• W1807712971 cites W2059013205 @default.
• W1807712971 cites W2059542392 @default.
• W1807712971 cites W2060523362 @default.
• W1807712971 cites W2061429827 @default.

• next