Matches in SemOpenAlex for { <https://semopenalex.org/work/W1808029263> ?p ?o ?g. }
- W1808029263 endingPage "808" @default.
- W1808029263 startingPage "801" @default.
- W1808029263 abstract "In limited resource settings monitoring antiretroviral (ARV) treatment efficacy is restrained by the lack of access to technological equipment. The aim of the study was to assess the use of dried plasma (DPS) and blood spots (DBS) to facilitate ARV monitoring in remote settings where clinical monitoring is the primary strategy.A cross-sectional study in HIV-positive ARV-treated patients in Kiremba, Burundi was performed. DBS were used for HIV-1 viral load (limit of the assay 250 copies ml(-1)) and genotypic drug resistance tests and dried plasma spots were used for concentration measurements.Three hundred and seven patients [201 female (88.6%), 14 children (4.5%)] were enrolled. HIV-1 viral load was <250, 250-1000 and >1000 copies ml(-1) in 250 (81.7%), 33 (10.8%) and 23 patients (7.5%). Eleven samples out of 23 were successfully amplified revealing nucleoside reverse transcriptase inhibitor (NRTI) and non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistance associated mutations [in seven (58.3%) and six patients (50%)]. Nevirapine trough concentrations were <3000 ng ml(-1) in 28/189 patients (14.8%) and efavirenz 12 h concentrations were <1000 ng ml(-1) in 2/16 patients (12.5%). Children and patients with nevirapine exposure <3000 ng ml(-1) presented a higher risk of viral replication.Viral loads <250 copies ml(-1) were observed in 81.7% of patients (83.6% adults and 42.9% children). Children and patients with low nevirapine concentrations had higher risk of viral replication. Dried blood and plasma spots may be useful for monitoring HIV-positive patients including viral load and drug level measurement as part of treatment management in remote areas." @default.
- W1808029263 created "2016-06-24" @default.
- W1808029263 creator A5003451849 @default.
- W1808029263 creator A5016697980 @default.
- W1808029263 creator A5021206943 @default.
- W1808029263 creator A5024610429 @default.
- W1808029263 creator A5033986344 @default.
- W1808029263 creator A5037132693 @default.
- W1808029263 creator A5039193151 @default.
- W1808029263 creator A5052366087 @default.
- W1808029263 creator A5065675527 @default.
- W1808029263 creator A5076836884 @default.
- W1808029263 creator A5077699502 @default.
- W1808029263 date "2015-04-22" @default.
- W1808029263 modified "2023-10-17" @default.
- W1808029263 title "Dried plasma/blood spots for monitoring antiretroviral treatment efficacy and pharmacokinetics: a cross-sectional study in rural Burundi" @default.
- W1808029263 cites W1531424682 @default.
- W1808029263 cites W1600314899 @default.
- W1808029263 cites W1794134895 @default.
- W1808029263 cites W1986608467 @default.
- W1808029263 cites W2001316390 @default.
- W1808029263 cites W2023454109 @default.
- W1808029263 cites W2029246165 @default.
- W1808029263 cites W2043216606 @default.
- W1808029263 cites W2056819207 @default.
- W1808029263 cites W2064210857 @default.
- W1808029263 cites W2069526121 @default.
- W1808029263 cites W2082808145 @default.
- W1808029263 cites W2120293408 @default.
- W1808029263 cites W2124543441 @default.
- W1808029263 cites W2135892517 @default.
- W1808029263 cites W2137850028 @default.
- W1808029263 cites W2161827987 @default.
- W1808029263 cites W2166949679 @default.
- W1808029263 cites W2167806904 @default.
- W1808029263 doi "https://doi.org/10.1111/bcp.12544" @default.
- W1808029263 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4415716" @default.
- W1808029263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25377591" @default.
- W1808029263 hasPublicationYear "2015" @default.
- W1808029263 type Work @default.
- W1808029263 sameAs 1808029263 @default.
- W1808029263 citedByCount "14" @default.
- W1808029263 countsByYear W18080292632016 @default.
- W1808029263 countsByYear W18080292632017 @default.
- W1808029263 countsByYear W18080292632019 @default.
- W1808029263 countsByYear W18080292632021 @default.
- W1808029263 countsByYear W18080292632022 @default.
- W1808029263 countsByYear W18080292632023 @default.
- W1808029263 crossrefType "journal-article" @default.
- W1808029263 hasAuthorship W1808029263A5003451849 @default.
- W1808029263 hasAuthorship W1808029263A5016697980 @default.
- W1808029263 hasAuthorship W1808029263A5021206943 @default.
- W1808029263 hasAuthorship W1808029263A5024610429 @default.
- W1808029263 hasAuthorship W1808029263A5033986344 @default.
- W1808029263 hasAuthorship W1808029263A5037132693 @default.
- W1808029263 hasAuthorship W1808029263A5039193151 @default.
- W1808029263 hasAuthorship W1808029263A5052366087 @default.
- W1808029263 hasAuthorship W1808029263A5065675527 @default.
- W1808029263 hasAuthorship W1808029263A5076836884 @default.
- W1808029263 hasAuthorship W1808029263A5077699502 @default.
- W1808029263 hasBestOaLocation W18080292631 @default.
- W1808029263 hasConcept C104317684 @default.
- W1808029263 hasConcept C112705442 @default.
- W1808029263 hasConcept C114851261 @default.
- W1808029263 hasConcept C126322002 @default.
- W1808029263 hasConcept C142462285 @default.
- W1808029263 hasConcept C156719811 @default.
- W1808029263 hasConcept C159047783 @default.
- W1808029263 hasConcept C185592680 @default.
- W1808029263 hasConcept C2776597655 @default.
- W1808029263 hasConcept C2777351918 @default.
- W1808029263 hasConcept C2779130552 @default.
- W1808029263 hasConcept C2780272996 @default.
- W1808029263 hasConcept C2781432083 @default.
- W1808029263 hasConcept C2993143319 @default.
- W1808029263 hasConcept C3013748606 @default.
- W1808029263 hasConcept C3017516299 @default.
- W1808029263 hasConcept C43617362 @default.
- W1808029263 hasConcept C49105822 @default.
- W1808029263 hasConcept C54355233 @default.
- W1808029263 hasConcept C55493867 @default.
- W1808029263 hasConcept C71924100 @default.
- W1808029263 hasConcept C86803240 @default.
- W1808029263 hasConcept C89423630 @default.
- W1808029263 hasConcept C90924648 @default.
- W1808029263 hasConcept C98274493 @default.
- W1808029263 hasConceptScore W1808029263C104317684 @default.
- W1808029263 hasConceptScore W1808029263C112705442 @default.
- W1808029263 hasConceptScore W1808029263C114851261 @default.
- W1808029263 hasConceptScore W1808029263C126322002 @default.
- W1808029263 hasConceptScore W1808029263C142462285 @default.
- W1808029263 hasConceptScore W1808029263C156719811 @default.
- W1808029263 hasConceptScore W1808029263C159047783 @default.
- W1808029263 hasConceptScore W1808029263C185592680 @default.
- W1808029263 hasConceptScore W1808029263C2776597655 @default.
- W1808029263 hasConceptScore W1808029263C2777351918 @default.
- W1808029263 hasConceptScore W1808029263C2779130552 @default.
- W1808029263 hasConceptScore W1808029263C2780272996 @default.