Matches in SemOpenAlex for { <https://semopenalex.org/work/W1808276149> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W1808276149 endingPage "92" @default.
- W1808276149 startingPage "588" @default.
- W1808276149 abstract "Cytokines, interleukin-1 (IL-1) and tumor necrosis factor (TNF) are known to mediate host cell response to sepsis, trauma, and myocardial ischemia. We have previously found increased levels of IL-1 in the venous effluent during the reperfusion phase of skeletal muscle ischemia in a canine model. This study was done to evaluate whether TNF also played a role in skeletal muscle ischemia-reperfusion injury since IL-1 and TNF have inter-related functions. In twelve adult mongrel dogs (28-32 kg) one gracilis muscle was subjected to six hours of normothermic ischemia followed by normothermic reperfusion. The contralateral side served as a control and remained normally perfused throughout the experiment. Gracilis venous samples were collected at pre-ischemia and one hour of reperfusion. Systemic (arterial) blood samples were taken simultaneously with the venous samples at one hour of reperfusion. At the end of the experiment the muscles were harvested and amount of necrosis quantitated by serial transections, nitroblue tetrazolium staining and computerized planimetry. Muscle necrosis on the experimental side was found to be 48.86 +/- 5.37%. Sera were analyzed for TNF activity using a bioassay. TNF levels in the gracilis venous effluent at one hour of reperfusion were not significantly different from the simultaneous systemic (arterial) levels (27.15 +/- 5.05 pg/ml vs 18.23 +/- 4.27 pg/ml). Pre-ischemic levels of TNF were 96.50 +/- 20.12 pg/ml, which was significantly higher than either venous or arterial levels obtained after one hour of reperfusion (p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W1808276149 created "2016-06-24" @default.
- W1808276149 creator A5008945784 @default.
- W1808276149 creator A5016825036 @default.
- W1808276149 creator A5036202443 @default.
- W1808276149 creator A5062184194 @default.
- W1808276149 date "1992-09-01" @default.
- W1808276149 modified "2023-09-27" @default.
- W1808276149 title "Do cytokines play a role in skeletal muscle ischemia and reperfusion?" @default.
- W1808276149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1447279" @default.
- W1808276149 hasPublicationYear "1992" @default.
- W1808276149 type Work @default.
- W1808276149 sameAs 1808276149 @default.
- W1808276149 citedByCount "5" @default.
- W1808276149 countsByYear W18082761492017 @default.
- W1808276149 countsByYear W18082761492018 @default.
- W1808276149 crossrefType "journal-article" @default.
- W1808276149 hasAuthorship W1808276149A5008945784 @default.
- W1808276149 hasAuthorship W1808276149A5016825036 @default.
- W1808276149 hasAuthorship W1808276149A5036202443 @default.
- W1808276149 hasAuthorship W1808276149A5062184194 @default.
- W1808276149 hasConcept C126322002 @default.
- W1808276149 hasConcept C146957229 @default.
- W1808276149 hasConcept C17991360 @default.
- W1808276149 hasConcept C2778384902 @default.
- W1808276149 hasConcept C2779959927 @default.
- W1808276149 hasConcept C2780114680 @default.
- W1808276149 hasConcept C2780371428 @default.
- W1808276149 hasConcept C42219234 @default.
- W1808276149 hasConcept C43044207 @default.
- W1808276149 hasConcept C503630168 @default.
- W1808276149 hasConcept C541997718 @default.
- W1808276149 hasConcept C71924100 @default.
- W1808276149 hasConceptScore W1808276149C126322002 @default.
- W1808276149 hasConceptScore W1808276149C146957229 @default.
- W1808276149 hasConceptScore W1808276149C17991360 @default.
- W1808276149 hasConceptScore W1808276149C2778384902 @default.
- W1808276149 hasConceptScore W1808276149C2779959927 @default.
- W1808276149 hasConceptScore W1808276149C2780114680 @default.
- W1808276149 hasConceptScore W1808276149C2780371428 @default.
- W1808276149 hasConceptScore W1808276149C42219234 @default.
- W1808276149 hasConceptScore W1808276149C43044207 @default.
- W1808276149 hasConceptScore W1808276149C503630168 @default.
- W1808276149 hasConceptScore W1808276149C541997718 @default.
- W1808276149 hasConceptScore W1808276149C71924100 @default.
- W1808276149 hasIssue "5" @default.
- W1808276149 hasLocation W18082761491 @default.
- W1808276149 hasOpenAccess W1808276149 @default.
- W1808276149 hasPrimaryLocation W18082761491 @default.
- W1808276149 hasRelatedWork W1808276149 @default.
- W1808276149 hasRelatedWork W2040328919 @default.
- W1808276149 hasRelatedWork W2082695343 @default.
- W1808276149 hasRelatedWork W2085560184 @default.
- W1808276149 hasRelatedWork W2123638924 @default.
- W1808276149 hasRelatedWork W2133436804 @default.
- W1808276149 hasRelatedWork W2371656075 @default.
- W1808276149 hasRelatedWork W2373013795 @default.
- W1808276149 hasRelatedWork W2394332794 @default.
- W1808276149 hasRelatedWork W3029585758 @default.
- W1808276149 hasVolume "33" @default.
- W1808276149 isParatext "false" @default.
- W1808276149 isRetracted "false" @default.
- W1808276149 magId "1808276149" @default.
- W1808276149 workType "article" @default.