Matches in SemOpenAlex for { <https://semopenalex.org/work/W1808397605> ?p ?o ?g. }
- W1808397605 endingPage "17250" @default.
- W1808397605 startingPage "17237" @default.
- W1808397605 abstract "Phosphoglycerate mutase (PGAM), a conserved, glycolytic enzyme has been found in nucleoli of cancer cells. Here, we present evidence that accumulation of PGAM in the nucleolus is a universal phenomenon concerning not only neoplastically transformed but also non-malignant cells. Nucleolar localization of the enzyme is dependent on the presence of the PGAM2 (muscle) subunit and is regulated by insulin/IGF-1-PI3K signaling pathway as well as drugs influencing ribosomal biogenesis. We document that PGAM interacts with several 40S and 60S ribosomal proteins and that silencing of PGAM2 expression results in disturbance of nucleolar structure, inhibition of RNA synthesis and decrease of the mitotic index of squamous cell carcinoma cells. We conclude that presence of PGAM in the nucleolus is a prerequisite for synthesis and initial assembly of new pre-ribosome subunits." @default.
- W1808397605 created "2016-06-24" @default.
- W1808397605 creator A5008902457 @default.
- W1808397605 creator A5022831317 @default.
- W1808397605 creator A5030391285 @default.
- W1808397605 creator A5038928679 @default.
- W1808397605 creator A5039025880 @default.
- W1808397605 creator A5054638360 @default.
- W1808397605 creator A5064634385 @default.
- W1808397605 creator A5082425228 @default.
- W1808397605 creator A5091584856 @default.
- W1808397605 date "2015-05-08" @default.
- W1808397605 modified "2023-10-16" @default.
- W1808397605 title "Insulin/IGF1-PI3K-dependent nucleolar localization of a glycolytic enzyme - phosphoglycerate mutase 2, is necessary for proper structure of nucleolus and RNA synthesis" @default.
- W1808397605 cites W1952806621 @default.
- W1808397605 cites W1980373840 @default.
- W1808397605 cites W1984990382 @default.
- W1808397605 cites W1986504113 @default.
- W1808397605 cites W1999440327 @default.
- W1808397605 cites W2002373110 @default.
- W1808397605 cites W2002658208 @default.
- W1808397605 cites W2006165679 @default.
- W1808397605 cites W2006724749 @default.
- W1808397605 cites W2034147352 @default.
- W1808397605 cites W2036490858 @default.
- W1808397605 cites W2044269002 @default.
- W1808397605 cites W2045437235 @default.
- W1808397605 cites W2048653746 @default.
- W1808397605 cites W2052156572 @default.
- W1808397605 cites W2060094839 @default.
- W1808397605 cites W2069616912 @default.
- W1808397605 cites W2075213054 @default.
- W1808397605 cites W2083309296 @default.
- W1808397605 cites W2089144633 @default.
- W1808397605 cites W2090906760 @default.
- W1808397605 cites W2093232223 @default.
- W1808397605 cites W2096602351 @default.
- W1808397605 cites W2098940538 @default.
- W1808397605 cites W2105246953 @default.
- W1808397605 cites W2109600717 @default.
- W1808397605 cites W2113051549 @default.
- W1808397605 cites W2113333661 @default.
- W1808397605 cites W2125316486 @default.
- W1808397605 cites W2134762011 @default.
- W1808397605 cites W2135129680 @default.
- W1808397605 cites W2141202224 @default.
- W1808397605 cites W2145170363 @default.
- W1808397605 cites W2149062070 @default.
- W1808397605 cites W2152983548 @default.
- W1808397605 cites W2187568708 @default.
- W1808397605 cites W2301131921 @default.
- W1808397605 cites W2323029819 @default.
- W1808397605 doi "https://doi.org/10.18632/oncotarget.4044" @default.
- W1808397605 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4627304" @default.
- W1808397605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26033454" @default.
- W1808397605 hasPublicationYear "2015" @default.
- W1808397605 type Work @default.
- W1808397605 sameAs 1808397605 @default.
- W1808397605 citedByCount "10" @default.
- W1808397605 countsByYear W18083976052017 @default.
- W1808397605 countsByYear W18083976052019 @default.
- W1808397605 countsByYear W18083976052020 @default.
- W1808397605 countsByYear W18083976052021 @default.
- W1808397605 countsByYear W18083976052022 @default.
- W1808397605 crossrefType "journal-article" @default.
- W1808397605 hasAuthorship W1808397605A5008902457 @default.
- W1808397605 hasAuthorship W1808397605A5022831317 @default.
- W1808397605 hasAuthorship W1808397605A5030391285 @default.
- W1808397605 hasAuthorship W1808397605A5038928679 @default.
- W1808397605 hasAuthorship W1808397605A5039025880 @default.
- W1808397605 hasAuthorship W1808397605A5054638360 @default.
- W1808397605 hasAuthorship W1808397605A5064634385 @default.
- W1808397605 hasAuthorship W1808397605A5082425228 @default.
- W1808397605 hasAuthorship W1808397605A5091584856 @default.
- W1808397605 hasBestOaLocation W18083976051 @default.
- W1808397605 hasConcept C104317684 @default.
- W1808397605 hasConcept C181199279 @default.
- W1808397605 hasConcept C183873130 @default.
- W1808397605 hasConcept C190062978 @default.
- W1808397605 hasConcept C20251656 @default.
- W1808397605 hasConcept C2779419633 @default.
- W1808397605 hasConcept C38062823 @default.
- W1808397605 hasConcept C55493867 @default.
- W1808397605 hasConcept C67705224 @default.
- W1808397605 hasConcept C67905577 @default.
- W1808397605 hasConcept C86803240 @default.
- W1808397605 hasConcept C88478588 @default.
- W1808397605 hasConcept C91754966 @default.
- W1808397605 hasConcept C95444343 @default.
- W1808397605 hasConceptScore W1808397605C104317684 @default.
- W1808397605 hasConceptScore W1808397605C181199279 @default.
- W1808397605 hasConceptScore W1808397605C183873130 @default.
- W1808397605 hasConceptScore W1808397605C190062978 @default.
- W1808397605 hasConceptScore W1808397605C20251656 @default.
- W1808397605 hasConceptScore W1808397605C2779419633 @default.
- W1808397605 hasConceptScore W1808397605C38062823 @default.
- W1808397605 hasConceptScore W1808397605C55493867 @default.
- W1808397605 hasConceptScore W1808397605C67705224 @default.