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- W1808512047 abstract "Advances in neonatal care have led to a shift in the pathophysiology of bronchopulmonary dysplasia (BPD). The impact of contemporaneous preterm birth and BPD on long term respiratory health remains unclear. This study aims to relate mid-childhood respiratory function with neonatal variables in children born ≤32 w gestational age (GA). Methods: Children aged 9 to 11 y (≥ 37 w GA controls, n=37; 84 born ≤32 w gestation including 53 with BPD) performed 4 lung function tests (forced oscillation, static lung volumes, spirometry and gas transfer (DLCO)). Associations between lung function (expressed as Z scores) and neonatal variables (GA, birth weight Z-score and durations of mechanical ventilation (MV) and O 2 ) were explored using multiple linear regression. Results: Children with BPD had increased respiratory resistance (R rs ) and reactance (X rs ), reduced FEV 1 and FEF 25-75 compared to children born preterm without BPD and controls (one-way ANOVA; post-hoc comparisons p 2 was associated with increased R rs (p rs (p=0.001) and together with birth weight Z-score (p=0.02), was predictive of reduced FEV 1 (p=0.005). Conclusions: Children born ≤32w GA with BPD have worse lung function compared to preterm children without BPD. Impaired lung function in mid-childhood is associated with severity of neonatal lung disease as reflected by duration of MV and supplemental O 2 , further reinforcing the long–term impacts of preterm birth on lung health." @default.
- W1808512047 created "2016-06-24" @default.
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- W1808512047 date "2011-09-01" @default.
- W1808512047 modified "2023-09-27" @default.
- W1808512047 title "Impaired lung function in children born preterm is related to severity of neonatal lung disease" @default.
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