FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1808685515> ?p ?o ?g. }

• W1808685515 endingPage "1811" @default.
• W1808685515 startingPage "1806" @default.
• W1808685515 abstract "Cultures on corn of Fusarium moniliforme MRC 826 are known to cause leukoencephalomalacia in horses and to be toxic and hepatocarcinogenic in rats. Culture material of this F. moniliforme isolate has also been shown to exhibit cancer-promoting activity in a short-term cancer initiation-promotion bioassay with diethylnitrosamine-initiated rats and the induction of gamma-glutamyl-transpeptidase-positive (GGT+) foci as an endpoint after 4 weeks of promotion. This bioassay was used as a monitoring system to isolate cancer-promoting compounds from cultures of F. moniliforme MRC 826. Culture material was successively extracted with ethyl acetate and CH3OH-H2O (3:1). Most of the cancer-promoting activity was recovered in the CH3OH-H2O extract and remained in the aqueous phase following partitioning of this extract between CH3OH-H2O (1:3) and CHCl3. The CH3OH-H2O fraction was chromatographed on an Amberlite XAD-2 column, and the active fraction was eluted with CH3OH. This fraction was chromatographed on a silica gel column with CHCl3-CH3OH-CH3COOH (6:3:1) as eluent and further purified on a C18 reverse-phase column. Two pure compounds were isolated, and these have been chemically characterized and given the trivial names fumonisin B1 and B2. At least 2 g of the major compound fumonisin B1 was purified from 1 kg of culture material. Fumonisin B1 in the diet (0.1%) significantly (P less than 0.001) induced the formation of GGT+ foci in the livers of initiated as well as noninitiated rats.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W1808685515 created "2016-06-24" @default.
• W1808685515 creator A5029191212 @default.
• W1808685515 creator A5037876784 @default.
• W1808685515 creator A5042975404 @default.
• W1808685515 creator A5049420452 @default.
• W1808685515 creator A5054863324 @default.
• W1808685515 creator A5055347008 @default.
• W1808685515 creator A5068607705 @default.
• W1808685515 date "1988-07-01" @default.
• W1808685515 modified "2023-10-06" @default.
• W1808685515 title "Fumonisins--novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme" @default.
• W1808685515 cites W1589092930 @default.
• W1808685515 cites W1999442963 @default.
• W1808685515 cites W2001651654 @default.
• W1808685515 cites W2004586921 @default.
• W1808685515 cites W2043046008 @default.
• W1808685515 cites W2058217253 @default.
• W1808685515 cites W2062068817 @default.
• W1808685515 cites W2065503533 @default.
• W1808685515 cites W2070489818 @default.
• W1808685515 cites W2072891772 @default.
• W1808685515 cites W2116888647 @default.
• W1808685515 cites W2287741839 @default.
• W1808685515 cites W2298571585 @default.
• W1808685515 cites W69460816 @default.
• W1808685515 doi "https://doi.org/10.1128/aem.54.7.1806-1811.1988" @default.
• W1808685515 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/202749" @default.
• W1808685515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2901247" @default.
• W1808685515 hasPublicationYear "1988" @default.
• W1808685515 type Work @default.
• W1808685515 sameAs 1808685515 @default.
• W1808685515 citedByCount "1131" @default.
• W1808685515 countsByYear W18086855152012 @default.
• W1808685515 countsByYear W18086855152013 @default.
• W1808685515 countsByYear W18086855152014 @default.
• W1808685515 countsByYear W18086855152015 @default.
• W1808685515 countsByYear W18086855152016 @default.
• W1808685515 countsByYear W18086855152017 @default.
• W1808685515 countsByYear W18086855152018 @default.
• W1808685515 countsByYear W18086855152019 @default.
• W1808685515 countsByYear W18086855152020 @default.
• W1808685515 countsByYear W18086855152021 @default.
• W1808685515 countsByYear W18086855152022 @default.
• W1808685515 countsByYear W18086855152023 @default.
• W1808685515 crossrefType "journal-article" @default.
• W1808685515 hasAuthorship W1808685515A5029191212 @default.
• W1808685515 hasAuthorship W1808685515A5037876784 @default.
• W1808685515 hasAuthorship W1808685515A5042975404 @default.
• W1808685515 hasAuthorship W1808685515A5049420452 @default.
• W1808685515 hasAuthorship W1808685515A5054863324 @default.
• W1808685515 hasAuthorship W1808685515A5055347008 @default.
• W1808685515 hasAuthorship W1808685515A5068607705 @default.
• W1808685515 hasBestOaLocation W18086855151 @default.
• W1808685515 hasConcept C104488531 @default.
• W1808685515 hasConcept C114246631 @default.
• W1808685515 hasConcept C150394285 @default.
• W1808685515 hasConcept C178790620 @default.
• W1808685515 hasConcept C179998833 @default.
• W1808685515 hasConcept C185592680 @default.
• W1808685515 hasConcept C2778431908 @default.
• W1808685515 hasConcept C2778699723 @default.
• W1808685515 hasConcept C2778867309 @default.
• W1808685515 hasConcept C2779532046 @default.
• W1808685515 hasConcept C2779858419 @default.
• W1808685515 hasConcept C2781429003 @default.
• W1808685515 hasConcept C31903555 @default.
• W1808685515 hasConcept C43617362 @default.
• W1808685515 hasConcept C51724486 @default.
• W1808685515 hasConcept C54355233 @default.
• W1808685515 hasConcept C55493867 @default.
• W1808685515 hasConcept C59822182 @default.
• W1808685515 hasConcept C84699730 @default.
• W1808685515 hasConcept C86803240 @default.
• W1808685515 hasConcept C97428945 @default.
• W1808685515 hasConceptScore W1808685515C104488531 @default.
• W1808685515 hasConceptScore W1808685515C114246631 @default.
• W1808685515 hasConceptScore W1808685515C150394285 @default.
• W1808685515 hasConceptScore W1808685515C178790620 @default.
• W1808685515 hasConceptScore W1808685515C179998833 @default.
• W1808685515 hasConceptScore W1808685515C185592680 @default.
• W1808685515 hasConceptScore W1808685515C2778431908 @default.
• W1808685515 hasConceptScore W1808685515C2778699723 @default.
• W1808685515 hasConceptScore W1808685515C2778867309 @default.
• W1808685515 hasConceptScore W1808685515C2779532046 @default.
• W1808685515 hasConceptScore W1808685515C2779858419 @default.
• W1808685515 hasConceptScore W1808685515C2781429003 @default.
• W1808685515 hasConceptScore W1808685515C31903555 @default.
• W1808685515 hasConceptScore W1808685515C43617362 @default.
• W1808685515 hasConceptScore W1808685515C51724486 @default.
• W1808685515 hasConceptScore W1808685515C54355233 @default.
• W1808685515 hasConceptScore W1808685515C55493867 @default.
• W1808685515 hasConceptScore W1808685515C59822182 @default.
• W1808685515 hasConceptScore W1808685515C84699730 @default.
• W1808685515 hasConceptScore W1808685515C86803240 @default.
• W1808685515 hasConceptScore W1808685515C97428945 @default.
• W1808685515 hasIssue "7" @default.
• W1808685515 hasLocation W18086855151 @default.

• next