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- W1808773783 abstract "Malignant hyperthermia (MH) was first recognized in Australia in 1960. Malignant hyperthermia is a pharmacogenetic disease triggered by the depolarizing muscle relaxant suxamethonium and all the anesthetic vapors, although some are more potent triggers than others. Malignant hyperthermia has always been recognized as a skeletal muscle disease, involving the excitation-contraction (E-C) coupling mechanism, the means by which nervous activity is transferred to skeletal muscle activity at the neuromuscular junction. E-C coupling is a complex dynamic process in which Ca2+ plays a crucial role. Deep membrane projections (the T-tubules) into the sarcoplasm ensure rapid and even distribution of the impulse. Recent studies using skinned muscle fibers from MH-susceptible patients suggests that reduced Mg2+ concentrations may influence the effect of halothane on Ca2+ release and so have a clinical role in the development of an MH reaction. Malignant hyperthermia-susceptible patients only manifest when exposed to trigger agents, so appear outwardly normal and therefore cannot be identified preoperatively unless there is a personal/family history of anesthetic problems suggestive of MH. The clinical presentation of a MH crisis can be very variable and no one sign is unique to MH, making clinical diagnosis sometimes difficult. MH can develop insidiously over several hours, especially when small concentrations of a vapor are used during artificial ventilation, or it can develop into a dramatic full-blown life-threatening event within half an hour. With current monitoring standards it is apparent that the increase in temperature after which it is named is a comparatively late sign of MH." @default.
- W1808773783 created "2016-06-24" @default.
- W1808773783 creator A5027517883 @default.
- W1808773783 creator A5079491259 @default.
- W1808773783 date "2007-01-01" @default.
- W1808773783 modified "2023-10-16" @default.
- W1808773783 title "Malignant hyperthermia and associated conditions" @default.
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