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- W1808881512 abstract "Abstract The existence of dendritic cell (DC) subsets is firmly established, but their trafficking properties are virtually unknown. In this study, we show that myeloid (M-DCs) and plasmacytoid (P-DCs) DCs isolated from human blood differ widely in the capacity to migrate to chemotactic stimuli. The pattern of chemokine receptors expressed by blood M-DCs and P-DCs, with the exception of CCR7, is similar. However, most chemokine receptors of P-DCs, in particular those specific for inflammatory chemokines and classical chemotactic agonists, are not functional in circulating cells. Following maturation induced by CD40 ligation, the receptors for inflammatory chemokines are down-regulated, and CCR7 on P-DCs becomes coupled to migration. The drastically impaired capacity of blood P-DCs to migrate in response to inflammatory chemotactic signals contrasts with the response to lymph node-homing chemokines, indicating a propensity to migrate to secondary lymphoid organs rather than to sites of inflammation." @default.
- W1808881512 created "2016-06-24" @default.
- W1808881512 creator A5052594030 @default.
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- W1808881512 date "2001-08-15" @default.
- W1808881512 modified "2023-10-16" @default.
- W1808881512 title "Cutting Edge: Selective Usage of Chemokine Receptors by Plasmacytoid Dendritic Cells" @default.
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- W1808881512 doi "https://doi.org/10.4049/jimmunol.167.4.1862" @default.
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